Gene/Proteome Database (LMPD)

LMPD ID
LMP013591
Gene ID
500132
Species
Rattus norvegicus (Rat)
Gene Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Gene Symbol
Plekha8
Synonyms
FAPP-2; RGD1563940;
Alternate Names
pleckstrin homology domain-containing family A member 8; PH domain-containing family A member 8; phosphoinositol 4-phosphate adapter protein 2; phosphatidylinositol-four-phosphate adapter protein 2;
Chromosome
4
Map Location
4q24

Proteins

pleckstrin homology domain-containing family A member 8
Refseq ID NP_001102705
Protein GI 157823257
UniProt ID D3ZY60
mRNA ID NM_001109235
Length 520
MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVATAGVADSEEGIDVGTLLRSTCNTFLKTLEECMQIANAAFTSELLYHTPPGSPQLAVLKSSKMKHPIIPIHNSLERPIELNSCENGSLSVEVNGDEELLMKTKKSSLYLKSTKADCNISSEENTDGNTTVQGERMKEDGEENLESHDRDLAQPGSDSVCSPESPWEDSEEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVARVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAALTIKEGDHQKEAFSAGMQRDLSLYLPAMEKQLAILDTLYEIHGLESDEVV

Gene Information

Entrez Gene ID
500132
Gene Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Gene Symbol
Plekha8
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005802 ISS:UniProtKB C trans-Golgi network
GO:0097001 ISS:UniProtKB F ceramide binding
GO:0051861 ISS:UniProtKB F glycolipid binding
GO:0017089 ISS:UniProtKB F glycolipid transporter activity
GO:0070273 ISS:UniProtKB F phosphatidylinositol-4-phosphate binding
GO:0035621 ISS:UniProtKB P ER to Golgi ceramide transport
GO:0006869 ISS:UniProtKB P lipid transport
GO:0015031 IEA:UniProtKB-KW P protein transport

Domain Information

InterPro Annotations

Accession Description
IPR014830 Glycolipid transfer protein domain
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Protein Entry
PKHA8_RAT
UniProt ID
D3ZY60
Species
Rat

Comments

Comment Type Description
Domain The PH domain of FAPPS binds the small GTPase ARF1 and phosphatidylinositol-4-phosphate (PtdIns4P) with high selectivity, and is required for recruitment of FAPPs to the trans-Golgi network (TGN)
Function Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4- phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity)
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular Location Cytoplasm . Golgi apparatus, trans-Golgi network membrane . Membrane {ECO:0000250}; Peripheral membrane protein . Note=Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes (By similarity)
Subunit Homodimer. Interacts with ARF1; the interaction together with phosphatidylinositol 4-phosphate binding is required for FAPP2 GlcCer transfer ability

Identical and Related Proteins

Unique RefSeq proteins for LMP013591 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157823257 RefSeq NP_001102705 520 pleckstrin homology domain-containing family A member 8

Identical Sequences to LMP013591 proteins

Reference Database Accession Length Protein Name
GI:157823257 GenBank EDL88113.1 520 similar to phosphoinositol 4-phosphate adaptor protein-2 (predicted) [Rattus norvegicus]
GI:157823257 SwissProt D3ZY60.1 520 RecName: Full=Pleckstrin homology domain-containing family A member 8; Short=PH domain-containing family A member 8; AltName: Full=Phosphatidylinositol-four-phosphate adapter protein 2; Short=FAPP-2; Short=Phosphoinositol 4-phosphate adapter protein 2 [Rattus norvegicus]

Related Sequences to LMP013591 proteins

Reference Database Accession Length Protein Name
GI:157823257 GenBank EDL88113.1 520 similar to phosphoinositol 4-phosphate adaptor protein-2 (predicted) [Rattus norvegicus]
GI:157823257 RefSeq NP_001157833.1 519 pleckstrin homology domain-containing family A member 8 isoform 1 [Mus musculus]
GI:157823257 SwissProt Q80W71.2 519 RecName: Full=Pleckstrin homology domain-containing family A member 8; Short=PH domain-containing family A member 8; AltName: Full=Phosphatidylinositol-four-phosphate adapter protein 2; Short=FAPP-2; Short=Phosphoinositol 4-phosphate adapter protein 2 [Mus musculus]
GI:157823257 SwissProt D3ZY60.1 520 RecName: Full=Pleckstrin homology domain-containing family A member 8; Short=PH domain-containing family A member 8; AltName: Full=Phosphatidylinositol-four-phosphate adapter protein 2; Short=FAPP-2; Short=Phosphoinositol 4-phosphate adapter protein 2 [Rattus norvegicus]