Gene/Proteome Database (LMPD)

LMPD ID
LMP013601
Gene ID
501072
Species
Rattus norvegicus (Rat)
Gene Name
acetyl-Coenzyme A acyltransferase 1B
Gene Symbol
Acaa1b
Synonyms
RGD1562373;
Alternate Names
3-ketoacyl-CoA thiolase B, peroxisomal; beta-ketothiolase B; acetyl-CoA acyltransferase B; peroxisomal 3-oxoacyl-CoA thiolase B; peroxisomal 3-ketoacyl-CoA thiolase B;
Chromosome
8
Map Location
8q32
EC Number
2.3.1.16

Proteins

3-ketoacyl-CoA thiolase B, peroxisomal precursor
Refseq ID NP_001035108
Protein GI 90968642
UniProt ID P07871
mRNA ID NM_001040019
Length 424
MHRLQVVLGHLAGRSESSSALQAAPCSAGFPQASASDVVVVHGQRTPIGRAGRGGFKDTTPDELLSAVLTAVLQDVKPKPECLGDISVGNVLQPGAGAAMARIAQFLSGIPETVPLSAVNRQCSSGLQAVANIAGGIRNGSYDIGMACGVESMTLSERGNPGNISSRLLENEKARDCLIPMGITSENVAERFGISRQKQDAFALASQQKAASAQSKGCFRAEIVPVTTTVLDDKGDRKTITVSQDEGVRPSTTMEGLAKLKPAFKDGGSTTAGNSSQVSDGAAAVLLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIGPAYAIPAALQKAGLTVNDIDIFEINEAFASQALYCVEKLGIPAEKVNPLGGAIALGHPLGCTGARQVVTLLNELKRRGRRAYGVVSMCIGTGMGAAAVFEYPGN
transit_peptide: 1..26 experiment: experimental evidence, no additional details recorded note: Peroxisome; propagated from UniProtKB/Swiss-Prot (P07871.2) calculated_mol_wt: 2719 peptide sequence: MHRLQVVLGHLAGRSESSSALQAAPC mat_peptide: 26..424 product: 3-ketoacyl-CoA thiolase B, peroxisomal calculated_mol_wt: 41178 peptide sequence: CSAGFPQASASDVVVVHGQRTPIGRAGRGGFKDTTPDELLSAVLTAVLQDVKPKPECLGDISVGNVLQPGAGAAMARIAQFLSGIPETVPLSAVNRQCSSGLQAVANIAGGIRNGSYDIGMACGVESMTLSERGNPGNISSRLLENEKARDCLIPMGITSENVAERFGISRQKQDAFALASQQKAASAQSKGCFRAEIVPVTTTVLDDKGDRKTITVSQDEGVRPSTTMEGLAKLKPAFKDGGSTTAGNSSQVSDGAAAVLLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIGPAYAIPAALQKAGLTVNDIDIFEINEAFASQALYCVEKLGIPAEKVNPLGGAIALGHPLGCTGARQVVTLLNELKRRGRRAYGVVSMCIGTGMGAAAVFEYPGN mat_peptide: 27..424 product: 3-ketoacyl-CoA thiolase B, peroxisomal experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P07871.2) calculated_mol_wt: 41075 peptide sequence: SAGFPQASASDVVVVHGQRTPIGRAGRGGFKDTTPDELLSAVLTAVLQDVKPKPECLGDISVGNVLQPGAGAAMARIAQFLSGIPETVPLSAVNRQCSSGLQAVANIAGGIRNGSYDIGMACGVESMTLSERGNPGNISSRLLENEKARDCLIPMGITSENVAERFGISRQKQDAFALASQQKAASAQSKGCFRAEIVPVTTTVLDDKGDRKTITVSQDEGVRPSTTMEGLAKLKPAFKDGGSTTAGNSSQVSDGAAAVLLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIGPAYAIPAALQKAGLTVNDIDIFEINEAFASQALYCVEKLGIPAEKVNPLGGAIALGHPLGCTGARQVVTLLNELKRRGRRAYGVVSMCIGTGMGAAAVFEYPGN

Gene Information

Entrez Gene ID
501072
Gene Name
acetyl-Coenzyme A acyltransferase 1B
Gene Symbol
Acaa1b
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005777 IDA:UniProtKB C peroxisome
GO:0003988 IEA:UniProtKB-EC F acetyl-CoA C-acyltransferase activity
GO:0006631 IEA:UniProtKB-UniPathway P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00592 alpha-Linolenic acid metabolism
rno00592 alpha-Linolenic acid metabolism
M00087 beta-Oxidation
ko01040 Biosynthesis of unsaturated fatty acids
rno01040 Biosynthesis of unsaturated fatty acids
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
rno01100 Metabolic pathways
ko04146 Peroxisome
rno04146 Peroxisome
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR020617 Thiolase, C-terminal
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup
IPR020616 Thiolase, N-terminal

UniProt Annotations

Entry Information

Gene Name
acetyl-Coenzyme A acyltransferase 1B
Protein Entry
THIKB_RAT
UniProt ID
P07871
Species
Rat

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
Induction Peroxisomal thiolase is markedly induced (at the level of transcription) by various hypolipidemic compounds in parallel with the other two enzymes of the peroxisomal beta-oxidation system.
Miscellaneous There exist at least 2 rat liver peroxisomal 3- ketoacyl-CoA thiolases.
Pathway Lipid metabolism; fatty acid metabolism.
Similarity Belongs to the thiolase family
Subcellular Location Peroxisome.
Subunit Homodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP013601 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
90968642 RefSeq NP_001035108 424 3-ketoacyl-CoA thiolase B, peroxisomal precursor

Identical Sequences to LMP013601 proteins

Reference Database Accession Length Protein Name
GI:90968642 GenBank AAA41497.1 424 peroxisomal 3-ketoacyl-CoA thiolase precursor (E.C 2.3.1.16) [Rattus norvegicus]

Related Sequences to LMP013601 proteins

Reference Database Accession Length Protein Name
GI:90968642 GenBank AAA41497.1 424 peroxisomal 3-ketoacyl-CoA thiolase precursor (E.C 2.3.1.16) [Rattus norvegicus]
GI:90968642 GenBank AAH98757.1 424 Similar to 3-ketoacyl-CoA thiolase B, peroxisomal precursor (Beta-ketothiolase B) [Rattus norvegicus]
GI:90968642 GenBank EDL76923.1 424 rCG25918, isoform CRA_b [Rattus norvegicus]
GI:90968642 SwissProt P07871.2 424 RecName: Full=3-ketoacyl-CoA thiolase B, peroxisomal; AltName: Full=Acetyl-CoA acyltransferase B; AltName: Full=Beta-ketothiolase B; AltName: Full=Peroxisomal 3-oxoacyl-CoA thiolase B; Flags: Precursor [Rattus norvegicus]