Gene/Proteome Database (LMPD)

LMPD ID
LMP013603
Gene ID
501283
Species
Rattus norvegicus (Rat)
Gene Name
perilipin 5
Gene Symbol
Plin5
Synonyms
Oxpat;
Alternate Names
perilipin-5; lipid storage droplet protein 5;
Chromosome
9
Map Location
chromosome:9

Proteins

perilipin-5
Refseq ID NP_001128109
Protein GI 197385053
UniProt ID M0R7Z9
mRNA ID NM_001134637
Length 475
MDQRGKDTTLALHSRMSGDQTAQDPGSSLGELDQHNVVKRVVALPLVRATCTAVSGAYNSAKDRHPLLGSACRFAEHCVCSVATCALDHAQPLLEHLQPKLATVNDLACRGLDKLEEKLPFLQQPSDTVVTSAKDAVAKSVTGVVDLAQRGRRWSGELRRSVSQAMDTVLRRSVSQAMDTVLGKSEELVDHFLPMTEAELVALATESQGPEVGSVEEQRQKQGYFVRLGSLSARLRHLAYQHSLGKLRESKHRTQEMLAQLQKTLELIQHMQSRASPTPTFHHPKVQELCGDWSPCLENGYRHSQVELETLALSRSLTLELQSAVDALAGCVRGLPPSAQAKVAEVQRSVDALQATFADAHCLGDVAPTALAEGQDSVAQAHACVDEFLDLVLRAMPLAWLVGPFAPILVERSEPLINLATCVDEVVGDPDPRWAHMDWPAQQRAWEAEPADPGGQEAEPPLGQVKHTMMPELDF

Gene Information

Entrez Gene ID
501283
Gene Name
perilipin 5
Gene Symbol
Plin5
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0005829 IEA:Ensembl C cytosol
GO:0005811 IDA:UniProtKB C lipid particle
GO:0005739 IDA:UniProtKB C mitochondrion
GO:0035473 IPI:UniProtKB F lipase binding
GO:0034389 ISS:UniProtKB P lipid particle organization
GO:0019915 IEA:Ensembl P lipid storage
GO:0051646 IEA:Ensembl P mitochondrion localization
GO:0031999 ISS:UniProtKB P negative regulation of fatty acid beta-oxidation
GO:0060192 ISS:UniProtKB P negative regulation of lipase activity
GO:0035359 ISS:UniProtKB P negative regulation of peroxisome proliferator activated receptor signaling pathway
GO:2000378 ISS:UniProtKB P negative regulation of reactive oxygen species metabolic process
GO:0010897 ISS:UniProtKB P negative regulation of triglyceride catabolic process
GO:0032000 IDA:UniProtKB P positive regulation of fatty acid beta-oxidation
GO:0060193 IDA:UniProtKB P positive regulation of lipase activity
GO:0010884 IDA:UniProtKB P positive regulation of lipid storage
GO:0010890 IDA:UniProtKB P positive regulation of sequestering of triglyceride
GO:0010867 ISS:UniProtKB P positive regulation of triglyceride biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR004279 Perilipin

UniProt Annotations

Entry Information

Gene Name
perilipin 5
Protein Entry
PLIN5_RAT
UniProt ID
M0R7Z9
Species
Rat

Comments

Comment Type Description
Function Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE. {ECO:0000269|PubMed:21885430, ECO:0000269|PubMed:22127648, ECO:0000269|PubMed:23353597}.
Ptm Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or upon lipolytic stimulation
Similarity Belongs to the perilipin family
Subcellular Location Lipid droplet. Cytoplasm. Mitochondrion. Note=Lipid droplet surface-associated. Exchanges between lipid droplets and the cytoplasm (By similarity)
Subunit Homooligomer. Interacts with PNPLA2; prevents interaction of PNPLA2 with ABHD5. Interacts with ABHD5; targets ABHD5 to lipid droplets and promotes interaction of ABHD5 with PNPLA2. Interacts with LIPE. {ECO:0000269|PubMed:23408028, ECO:0000269|PubMed:24303154}.

Identical and Related Proteins

Unique RefSeq proteins for LMP013603 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
197385053 RefSeq NP_001128109 475 perilipin-5

Identical Sequences to LMP013603 proteins

Reference Database Accession Length Protein Name
GI:197385053 GenBank EDL83657.1 475 similar to lipid droplet associated protein [Rattus norvegicus]
GI:197385053 SwissProt M0R7Z9.1 475 RecName: Full=Perilipin-5; AltName: Full=Lipid storage droplet protein 5 [Rattus norvegicus]

Related Sequences to LMP013603 proteins

Reference Database Accession Length Protein Name
GI:197385053 DBBJ BAC36019.1 463 unnamed protein product [Mus musculus]
GI:197385053 GenBank EDL83657.1 475 similar to lipid droplet associated protein [Rattus norvegicus]
GI:197385053 RefSeq XP_008764992.1 463 PREDICTED: perilipin-5 isoform X1 [Rattus norvegicus]
GI:197385053 SwissProt M0R7Z9.1 475 RecName: Full=Perilipin-5; AltName: Full=Lipid storage droplet protein 5 [Rattus norvegicus]