Gene/Proteome Database (LMPD)

LMPD ID
LMP013638
Gene ID
688705
Species
Rattus norvegicus (Rat)
Gene Name
diacylglycerol kinase, iota
Gene Symbol
Dgki
Synonyms
rDGKi-3;
Alternate Names
diacylglycerol kinase iota; DGK-iota; DAG kinase iota; diglyceride kinase iota; diacylglycerol kinase iota-3;
Chromosome
4
Map Location
4q22
EC Number
2.7.1.107
Summary
member of the family of diacylglyceride kinases which catalyze the phosphorylation of diacylglyceride to yield phosphatidic acid; involved in inositol lipid-mediated cell signaling [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Dgki

Proteins

diacylglycerol kinase iota
Refseq ID NP_942077
Protein GI 158508510
UniProt ID Q810C5
mRNA ID NM_198782
Length 1050
MDAAGRGCHLLPLPAARGPARAPAASSALSPAGLCSGTASASSAAAGAVAMNPSSSAGEERGATGGSSSSGSGAGSCCLGAEGGVDPRGAGAAAAAALEEPAAAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGTEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGLHYDKEKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQETSFPRAISAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPPGMPDLVVEQASGLSDWWNPALRKRMLSDSGMITPHYEDSDLKDFSHSRVLQSPVSSEDHAILQAVITGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGEIVKYILDHGPAELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAAYLESRQNYKIIGHEDLETAV

Gene Information

Entrez Gene ID
688705
Gene Name
diacylglycerol kinase, iota
Gene Symbol
Dgki
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:RGD C cytoplasm
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0004143 IDA:RGD F diacylglycerol kinase activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5953655 Effects of PIP2 hydrolysis
5953653 G alpha (q) signalling events
5953642 GPCR downstream signaling
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5953645 Hemostasis
5953644 Platelet activation, signaling and aggregation
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol kinase, iota
Protein Entry
Q810C5_RAT
UniProt ID
Q810C5
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate
Interaction Q62696:Dlg1; NbExp=3; IntAct=EBI-8523614, EBI-389325; Q63622:Dlg2; NbExp=3; IntAct=EBI-8523614, EBI-396947; Q62936:Dlg3; NbExp=2; IntAct=EBI-8523614, EBI-349596; P31016:Dlg4; NbExp=5; IntAct=EBI-8523614, EBI-375655;
Similarity Belongs to the eukaryotic diacylglycerol kinase family
Similarity Contains 1 DAGKc domain
Similarity Contains 2 ANK repeats

Identical and Related Proteins

Unique RefSeq proteins for LMP013638 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158508510 RefSeq NP_942077 1050 diacylglycerol kinase iota

Identical Sequences to LMP013638 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP013638 proteins

Reference Database Accession Length Protein Name
GI:158508510 DBBJ BAC66854.1 1050 diacylglycerol kinase iota-1 [Rattus norvegicus]
GI:158508510 RefSeq NP_001074675.1 1071 diacylglycerol kinase iota [Mus musculus]
GI:158508510 RefSeq XP_006236395.1 1071 PREDICTED: diacylglycerol kinase iota isoform X1 [Rattus norvegicus]
GI:158508510 RefSeq XP_006506323.1 1050 PREDICTED: diacylglycerol kinase iota isoform X6 [Mus musculus]