Gene/Proteome Database (LMPD)

LMPD ID
LMP013641
Gene ID
690163
Species
Rattus norvegicus (Rat)
Gene Name
3-oxoacid CoA transferase 1
Gene Symbol
Oxct1
Synonyms
SCOT;
Alternate Names
succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; scot-S; 3-oxoacid CoA-transferase 1; 3-oxoacid-CoA transferase 1; oxct1 {ECO:0000312|EMBL:AAI66478.1}; succinyl-CoA:3-ketoacid CoA transferase; somatic-type succinyl CoA:3-oxoacid CoA-transferase; somatic-type succinyl-CoA:3-oxoacid CoA-transferase; succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial;
Chromosome
2
Map Location
2q16
EC Number
2.8.3.5

Proteins

succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor
Refseq ID NP_001121052
Protein GI 189181716
UniProt ID B2GV06
mRNA ID NM_001127580
Length 520
MAALKLLSSGLRLCASARNSRGALHKGCACYFSVSTRHHTKFYTDPVEAVKDIPNGATLLVGGFGLCGIPENLIGALLKTGVKDLTAVSNNAGVDNFGLGLLLRSKQIKRMISSYVGENAEFERQFLSGELEVELTPQGTLAERIRAGGAGVPAFYTSTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFRGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAGTTVVEVEEIVDIGSFAPEDIHIPKIYVHRLIKGEKYEKRIERLSLRKEGEGKAKSGKPGEDVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNMTVHLQSENGVLGLGPYPLKDEADADLINAGKETVTVLPGASFFSSDESFAMIRGGHVNLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSSKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKGVFDVDKKNGLTLIELWEGLTVDDIRKSTGCDFAVSPNLMPMQQIST
transit_peptide: 1..39 experiment: experimental evidence, no additional details recorded note: Mitochondrion. {ECO:0000250|UniProtKB:P55809}; propagated from UniProtKB/Swiss-Prot (B2GV06.1) calculated_mol_wt: 4175 peptide sequence: MAALKLLSSGLRLCASARNSRGALHKGCACYFSVSTRHH mat_peptide: 40..520 product: Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (B2GV06.1) calculated_mol_wt: 52047 peptide sequence: TKFYTDPVEAVKDIPNGATLLVGGFGLCGIPENLIGALLKTGVKDLTAVSNNAGVDNFGLGLLLRSKQIKRMISSYVGENAEFERQFLSGELEVELTPQGTLAERIRAGGAGVPAFYTSTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFRGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAGTTVVEVEEIVDIGSFAPEDIHIPKIYVHRLIKGEKYEKRIERLSLRKEGEGKAKSGKPGEDVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNMTVHLQSENGVLGLGPYPLKDEADADLINAGKETVTVLPGASFFSSDESFAMIRGGHVNLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSSKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKGVFDVDKKNGLTLIELWEGLTVDDIRKSTGCDFAVSPNLMPMQQIST

Gene Information

Entrez Gene ID
690163
Gene Name
3-oxoacid CoA transferase 1
Gene Symbol
Oxct1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:RGD C mitochondrion
GO:0008260 IDA:RGD F 3-oxoacid CoA-transferase activity
GO:0042803 IDA:RGD F protein homodimerization activity
GO:0060612 IEP:RGD P adipose tissue development
GO:0007420 IEP:RGD P brain development
GO:0046950 IEP:RGD P cellular ketone body metabolic process
GO:0007507 IEP:RGD P heart development
GO:0046952 IEA:Ensembl P ketone body catabolic process
GO:0042182 IEA:Ensembl P ketone catabolic process
GO:0035774 IMP:RGD P positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0014823 IEP:RGD P response to activity
GO:0042493 IEP:RGD P response to drug
GO:0045471 IEP:RGD P response to ethanol
GO:0009725 IEP:RGD P response to hormone
GO:0007584 IEP:RGD P response to nutrient
GO:0042594 IEP:RGD P response to starvation

KEGG Pathway Links

KEGG Pathway ID Description
ko00650 Butanoate metabolism
rno00650 Butanoate metabolism
ko00072 Synthesis and degradation of ketone bodies
rno00072 Synthesis and degradation of ketone bodies
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953366 Ketone body metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953367 Utilization of Ketone Bodies

Domain Information

InterPro Annotations

Accession Description
IPR014388 3-oxoacid_CoA-transferase
IPR012792 3-oxoacid CoA-transferase, subunit A
IPR012791 3-oxoacid CoA-transferase, subunit B
IPR004164 Coenzyme A transferase active site
IPR004163 Coenzyme A transferase binding site
IPR004165 Coenzyme A transferase family I

UniProt Annotations

Entry Information

Gene Name
3-oxoacid CoA transferase 1
Protein Entry
SCOT1_RAT
UniProt ID
B2GV06
Species
Rat

Comments

Comment Type Description
Catalytic Activity Succinyl-CoA + a 3-oxo acid = succinate + a 3- oxoacyl-CoA. {ECO:0000250|UniProtKB:P55809, ECO:0000255|PROSITE- ProRule:PRU10034}.
Function Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)
Pathway Ketone metabolism; succinyl-CoA degradation; acetoacetyl- CoA from succinyl-CoA: step 1/1
Similarity Belongs to the 3-oxoacid CoA-transferase family
Subcellular Location Mitochondrion matrix .
Subunit Homodimer

Identical and Related Proteins

Unique RefSeq proteins for LMP013641 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
189181716 RefSeq NP_001121052 520 succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor

Identical Sequences to LMP013641 proteins

Reference Database Accession Length Protein Name
GI:189181716 GenBank EDL75738.1 520 rCG50966 [Rattus norvegicus]
GI:189181716 GenBank AAI66478.1 520 Oxct1 protein [Rattus norvegicus]
GI:189181716 SwissProt B2GV06.1 520 RecName: Full=Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; AltName: Full=3-oxoacid CoA-transferase 1; AltName: Full=Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; Short=SCOT-s; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013641 proteins

Reference Database Accession Length Protein Name
GI:189181716 DBBJ BAC05524.1 520 succinyl CoA transferase [Mus musculus]
GI:189181716 GenBank EDL75738.1 520 rCG50966 [Rattus norvegicus]
GI:189181716 GenBank AAI66478.1 520 Oxct1 protein [Rattus norvegicus]
GI:189181716 SwissProt B2GV06.1 520 RecName: Full=Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; AltName: Full=3-oxoacid CoA-transferase 1; AltName: Full=Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; Short=SCOT-s; Flags: Precursor [Rattus norvegicus]