Gene/Proteome Database (LMPD)

LMPD ID
LMP013778
Gene ID
713748
Species
Macaca mulatta (Rhesus monkey)
Gene Name
arachidonate 12-lipoxygenase
Gene Symbol
ALOX12
Alternate Names
arachidonate 12-lipoxygenase;
Chromosome
16
Map Location
chromosome:16

Proteins

Refseq ID XP_001104192
Protein GI 109112981
UniProt ID F7GAZ2
mRNA ID XM_001104192
Length 663
MGRYRIRVATGAWLFSGSHNRVQLWLVGARGEAELELQLRPARGEEEEFDRDVAEDLGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEAAFPCYRWVQGEDILSLPEGTARLPGDNALDVFQKHREKELKDRQQIYCWATWKEGLPLTIAAERKDDLPPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLEDFDQIFWGQKSVLAEKVHRCWQDDELFAYQFVNGANPMLLRRSTSLPSRLALPSGMEELRAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLLPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHQLQYHLLNTHLVAEVIAVATMRCLPGLHPIFKLLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRATAQLTYCSLCPPDDLADRGLLGLPGALYARDALRLWEIIARYVEGIVHLFYQRDDVVRGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVQQACLQMAISWHLGRRQPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLENLEKEITARNEQLDWPYEYLKPSCIENSVTI
Refseq ID XP_002800309
Protein GI 297271743
UniProt ID F7GAZ2
mRNA ID XM_001104192
Length 624
MGRYRIRVATGAWLFSGSHNRVQLWLVGARGEAELELQLRPARGEGPGACAEAAFPCYRWVQGEDILSLPEGTARLPGDNALDVFQKHREKELKDRQQIYCWATWKEGLPLTIAAERKDDLPPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLEDFDQIFWGQKSVLAEKVHRCWQDDELFAYQFVNGANPMLLRRSTSLPSRLALPSGMEELRAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLLPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHQLQYHLLNTHLVAEVIAVATMRCLPGLHPIFKLLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRATAQLTYCSLCPPDDLADRGLLGLPGALYARDALRLWEIIARYVEGIVHLFYQRDDVVRGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVQQACLQMAISWHLGRRQPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLENLEKEITARNEQLDWPYEYLKPSCIENSVTI

Gene Information

Entrez Gene ID
713748
Gene Name
arachidonate 12-lipoxygenase
Gene Symbol
ALOX12
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0042383 IEA:Ensembl C sarcolemma
GO:0004052 IEA:Ensembl F arachidonate 12-lipoxygenase activity
GO:0005506 IEA:InterPro F iron ion binding
GO:0016165 IEA:Ensembl F linoleate 13S-lipoxygenase activity
GO:0019369 IEA:Ensembl P arachidonic acid metabolic process
GO:0006928 IEA:Ensembl P cellular component movement
GO:0061436 IEA:Ensembl P establishment of skin barrier
GO:0019395 IEA:Ensembl P fatty acid oxidation
GO:1901751 IEA:Ensembl P leukotriene A4 metabolic process
GO:0043651 IEA:Ensembl P linoleic acid metabolic process
GO:2001303 IEA:Ensembl P lipoxin A4 biosynthetic process
GO:2001306 IEA:Ensembl P lipoxin B4 biosynthetic process
GO:0019372 IEA:Ensembl P lipoxygenase pathway
GO:0010656 IEA:Ensembl P negative regulation of muscle cell apoptotic process
GO:0090331 IEA:Ensembl P negative regulation of platelet aggregation
GO:0045766 IEA:Ensembl P positive regulation of angiogenesis
GO:0045785 IEA:Ensembl P positive regulation of cell adhesion
GO:0030307 IEA:Ensembl P positive regulation of cell growth
GO:0030335 IEA:Ensembl P positive regulation of cell migration
GO:0008284 IEA:Ensembl P positive regulation of cell proliferation

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
mcc00590 Arachidonic acid metabolism
ko04750 Inflammatory mediator regulation of TRP channels
mcc04750 Inflammatory mediator regulation of TRP channels
mcc01100 Metabolic pathways
mcc04726 Serotonergic synapse

Domain Information

InterPro Annotations

Accession Description
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR000907 Lipoxygenase
IPR013819 Lipoxygenase, C-terminal
IPR020834 Lipoxygenase, conserved site
IPR020833 Lipoxygenase, iron binding site
IPR001885 Lipoxygenase, mammalian
IPR001024 PLAT/LH2 domain

UniProt Annotations

Entry Information

Gene Name
arachidonate 12-lipoxygenase
Protein Entry
F7GAZ2_MACMU
UniProt ID
F7GAZ2
Species
Rhesus monkey

Comments

Comment Type Description
Caution The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Cofactor Note=Iron. ;
Similarity Belongs to the lipoxygenase family.
Similarity Contains PLAT domain.
Similarity Contains lipoxygenase domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP013778 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
109112981 RefSeq XP_001104192 663 arachidonate 12-lipoxygenase
297271743 RefSeq XP_002800309 624 arachidonate 12-lipoxygenase

Identical Sequences to LMP013778 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP013778 proteins

Reference Database Accession Length Protein Name
GI:297271743 RefSeq XP_003912258.1 663 PREDICTED: arachidonate 12-lipoxygenase, 12S-type [Papio anubis]
GI:297271743 RefSeq XP_005582748.1 663 PREDICTED: arachidonate 12-lipoxygenase, 12S-type [Macaca fascicularis]
GI:297271743 RefSeq XP_008008256.1 663 PREDICTED: arachidonate 12-lipoxygenase, 12S-type isoform X2 [Chlorocebus sabaeus]
GI:297271743 RefSeq XP_010375657.1 850 PREDICTED: arachidonate 12-lipoxygenase, 12S-type isoform X1 [Rhinopithecus roxellana]