Gene/Proteome Database (LMPD)

LMPD ID
LMP013968
Gene ID
678693
Species
Macaca mulatta (Rhesus monkey)
Gene Name
cytochrome P450c17
Gene Symbol
CYP17A1
Alternate Names
steroid 17-alpha-hydroxylase/17,20 lyase; CYPXVII; cytochrome P450-C17; cytochrome P450 17A1; cytochrome P450 17 alpha-hydroxylase; 17-alpha-hydroxyprogesterone aldolase; cytochrome P450, family 17, subfamily A, polypeptide 1;
Chromosome
9
Map Location
chromosome:9
EC Number
1.14.99.9

Proteins

steroid 17-alpha-hydroxylase/17,20 lyase precursor
Refseq ID NP_001035322
Protein GI 94159022
UniProt ID Q8HYM9
mRNA ID NM_001040232
Length 508
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTLDILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQTIDISFPVFVAITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLFPWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFHSDSITNMLDVLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGNPKVVFLIDSFKVKIKVRQAWREAQAEGST
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2193 peptide sequence: MWELVALLLLTLAYLFWP

Gene Information

Entrez Gene ID
678693
Gene Name
cytochrome P450c17
Gene Symbol
CYP17A1
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0047442 IEA:UniProtKB-EC F 17-alpha-hydroxyprogesterone aldolase activity
GO:0020037 ISS:UniProtKB F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004508 ISS:UniProtKB F steroid 17-alpha-monooxygenase activity
GO:0042446 ISS:UniProtKB P hormone biosynthetic process
GO:0042448 ISS:UniProtKB P progesterone metabolic process
GO:0006694 IEA:UniProtKB-UniPathway P steroid biosynthetic process
GO:0008202 ISS:UniProtKB P steroid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
M00110 C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
mcc_M00110 C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
M00109 C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
mcc_M00109 C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
mcc01100 Metabolic pathways
ko04913 Ovarian steroidogenesis
mcc04913 Ovarian steroidogenesis
ko04917 Prolactin signaling pathway
mcc04917 Prolactin signaling pathway
ko00140 Steroid hormone biosynthesis
mcc00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450c17
Protein Entry
CP17A_MACMU
UniProt ID
Q8HYM9
Species
Rhesus monkey

Comments

Comment Type Description
Catalytic Activity 17-alpha-hydroxyprogesterone = androst-4-ene- 3,17-dione + acetaldehyde.
Catalytic Activity A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O(2) = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Function Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction (By similarity).
Pathway Lipid metabolism; steroid biosynthesis.
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Membrane

Identical and Related Proteins

Unique RefSeq proteins for LMP013968 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
94159022 RefSeq NP_001035322 508 steroid 17-alpha-hydroxylase/17,20 lyase precursor

Identical Sequences to LMP013968 proteins

Reference Database Accession Length Protein Name
GI:94159022 GenBank AAW45723.1 508 cytochrome P450 17 alpha-hydroxylase [Macaca mulatta]
GI:94159022 GenBank ABB76808.1 508 cytochrome P450 17 alpha-hydroxylase [Macaca fascicularis]
GI:94159022 GenBank EHH64988.1 508 hypothetical protein EGM_18325 [Macaca fascicularis]
GI:94159022 SwissProt Q2XVA1.1 508 RecName: Full=Steroid 17-alpha-hydroxylase/17,20 lyase; AltName: Full=17-alpha-hydroxyprogesterone aldolase; AltName: Full=CYPXVII; AltName: Full=Cytochrome P450 17A1; AltName: Full=Cytochrome P450-C17; Short=Cytochrome P450c17 [Macaca fascicularis]

Related Sequences to LMP013968 proteins

Reference Database Accession Length Protein Name
GI:94159022 GenBank AAN86253.1 508 cytochrome P450c17 [Macaca mulatta]