Gene/Proteome Database (LMPD)
LMPD ID
LMP014021
Gene ID
Species
Macaca mulatta (Rhesus monkey)
Gene Name
dihydrolipoamide S-acetyltransferase
Gene Symbol
Alternate Names
dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;
Chromosome
14
Map Location
chromosome:14
EC Number
2.3.1.12
Proteins
| dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial | |
|---|---|
| Refseq ID | NP_001244504 |
| Protein GI | 383872250 |
| UniProt ID | F6ZQ28 |
| mRNA ID | NM_001257575 |
| Length | 647 |
| Protein sequence is identical to GI:109108634 (mRNA isoform) | |
| Refseq ID | XP_002799814 |
| Protein GI | 297269182 |
| UniProt ID | F6ZQ28 |
| mRNA ID | XM_001107013 |
| Length | 591 |
| MGGTRGSVDGLAGGTRNSTSVLAIWPGSGSSQQRDYRVPLPSLSPTMQAGTIARWEKKEGDKINEGDLIAEVETDKATVGFESLEECYMAKILVAEGTRDVPIGAIICITVGKPEDIEAFKNYTLDSSPAPTPQAAPAPTPAATASPPIPSAQAPGSSYPPHMQVLLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCIIVEKEADISAFADYRPTEVTDLKPQAPPPTPPPVATVPPTPQPLAPTPSAPCPATPAGPKGRVFVSPLAKKLAVEKGIDLTQVKGTGPDGRITKKDIDSFVPSKAAPAPAAVVPPTGPGMAPVPTGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKELNKILEGRSKISVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGLETIANDVVSLAAKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLVPADNEKGFDVASMMSVTLSCDHRVVDGAVGAQWLAEFRKYLEKPVTMLL | |
| Refseq ID | XP_001107013 |
| Protein GI | 109108634 |
| UniProt ID | F6ZQ28 |
| mRNA ID | XM_001107013 |
| Length | 647 |
| MWRVCARRAQNVAPWAGLEARWTALQEVPGTPRVSSRFGPAPARRNSATTGYGGVRALCGWTPSSGATPRNRLLLQLLGSPGRRCYSLPPHQKVPLPSLSPTMQAGTIARWEKKEGDKINEGDLIAEVETDKATVGFESLEECYMAKILVAEGTRDVPIGAIICITVGKPEDIEAFKNYTLDSSPAPTPQAAPAPTPAATASPPIPSAQAPGSSYPPHMQVLLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCIIVEKEADISAFADYRPTEVTDLKPQAPPPTPPPVATVPPTPQPLAPTPSAPCPATPAGPKGRVFVSPLAKKLAVEKGIDLTQVKGTGPDGRITKKDIDSFVPSKAAPAPAAVVPPTGPGMAPVPTGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKELNKILEGRSKISVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGLETIANDVVSLAAKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLVPADNEKGFDVASMMSVTLSCDHRVVDGAVGAQWLAEFRKYLEKPVTMLL | |
Gene Information
Entrez Gene ID
Gene Name
dihydrolipoamide S-acetyltransferase
Gene Symbol
Species
Macaca mulatta
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005759 | IEA:UniProtKB-SubCell | C | mitochondrial matrix |
| GO:0045254 | IEA:InterPro | C | pyruvate dehydrogenase complex |
| GO:0004742 | IEA:UniProtKB-EC | F | dihydrolipoyllysine-residue acetyltransferase activity |
| GO:0006090 | IEA:InterPro | P | pyruvate metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko01200 | Carbon metabolism |
| mcc01200 | Carbon metabolism |
| ko00020 | Citrate cycle (TCA cycle) |
| mcc00020 | Citrate cycle (TCA cycle) |
| ko00010 | Glycolysis / Gluconeogenesis |
| mcc00010 | Glycolysis / Gluconeogenesis |
| mcc01100 | Metabolic pathways |
| ko00620 | Pyruvate metabolism |
| mcc00620 | Pyruvate metabolism |
| M00307 | Pyruvate oxidation, pyruvate => acetyl-CoA |
| mcc_M00307 | Pyruvate oxidation, pyruvate => acetyl-CoA |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR003016 | 2-oxo acid dehydrogenase, lipoyl-binding site |
| IPR001078 | 2-oxoacid dehydrogenase acyltransferase, catalytic domain |
| IPR000089 | Biotin/lipoyl attachment |
| IPR023213 | Chloramphenicol acetyltransferase-like domain |
| IPR006257 | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
| IPR004167 | E3-binding domain |
| IPR011053 | Single hybrid motif |
UniProt Annotations
Entry Information
Gene Name
dihydrolipoamide S-acetyltransferase
Protein Entry
F6ZQ28_MACMU
UniProt ID
Species
Rhesus monkey
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. |
| Cofactor | Note=Binds 1 lipoyl cofactor covalently. ; |
| Cofactor | Note=Binds 2 lipoyl cofactors covalently. ; |
| Cofactor | Note=Binds 3 lipoyl cofactors covalently. ; |
| Function | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). |
| Similarity | Belongs to the 2-oxoacid dehydrogenase family. |
| Similarity | Contains 2 lipoyl-binding domains. |
| Subcellular Location | Mitochondrion matrix |
Identical and Related Proteins
Unique RefSeq proteins for LMP014021 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 109108634 | RefSeq | XP_001107013 | 647 | dihydrolipoamide S-acetyltransferase |
| 297269182 | RefSeq | XP_002799814 | 591 | dihydrolipoamide S-acetyltransferase |
Identical Sequences to LMP014021 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:383872250 | GenBank | AFE76981.1 | 647 | dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor [Macaca mulatta] |
| GI:383872250 | GenBank | AFH31347.1 | 647 | dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor [Macaca mulatta] |
| GI:383872250 | GenBank | AFI34063.1 | 647 | dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor [Macaca mulatta] |
| GI:383872250 | RefSeq | XP_005579678.1 | 647 | PREDICTED: dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial [Macaca fascicularis] |
Related Sequences to LMP014021 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|