Gene/Proteome Database (LMPD)

LMPD ID
LMP014071
Gene ID
613025
Species
Macaca mulatta (Rhesus monkey)
Gene Name
estrogen receptor 1
Gene Symbol
ESR1
Synonyms
ER;
Alternate Names
estrogen receptor 1; ER-alpha; estradiol receptor; nuclear receptor subfamily 3 group A member 1;
Chromosome
4
Map Location
chromosome:4

Proteins

Refseq ID XP_001097228
Protein GI 109072322
UniProt ID F6QUN5
mRNA ID XM_002803858
Length 595
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYVDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKHSKKNSPALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGAPMEETDQSHLATAGSTSSHSLQKYYITGDAEGFPATV
Refseq ID XP_002803904
Protein GI 297291506
UniProt ID F6QUN5
mRNA ID XM_002803858
Length 595
Protein sequence is identical to GI:109072322 (mRNA isoform)

Gene Information

Entrez Gene ID
613025
Gene Name
estrogen receptor 1
Gene Symbol
ESR1
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:Ensembl C cytoplasm
GO:0005634 IEA:UniProtKB-SubCell C nucleus
GO:0005886 IEA:Ensembl C plasma membrane
GO:0003682 IEA:Ensembl F chromatin binding
GO:0001046 IEA:Ensembl F core promoter sequence-specific DNA binding
GO:0038052 IEA:Ensembl F estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0034056 IEA:Ensembl F estrogen response element binding
GO:0000978 IEA:Ensembl F RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA:Ensembl F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0005496 IEA:UniProtKB-KW F steroid binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0008209 IEA:Ensembl P androgen metabolic process
GO:0001547 IEA:Ensembl P antral ovarian follicle growth
GO:0071391 IEA:Ensembl P cellular response to estrogen stimulus
GO:0002064 IEA:Ensembl P epithelial cell development
GO:0060750 IEA:Ensembl P epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584 IEA:Ensembl P male gonad development
GO:0060749 IEA:Ensembl P mammary gland alveolus development
GO:0060745 IEA:Ensembl P mammary gland branching involved in pregnancy
GO:0010629 IEA:Ensembl P negative regulation of gene expression
GO:0043124 IEA:Ensembl P negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043433 IEA:Ensembl P negative regulation of sequence-specific DNA binding transcription factor activity
GO:0048146 IEA:Ensembl P positive regulation of fibroblast proliferation
GO:0045429 IEA:Ensembl P positive regulation of nitric oxide biosynthetic process
GO:0051000 IEA:Ensembl P positive regulation of nitric-oxide synthase activity
GO:0048386 IEA:Ensembl P positive regulation of retinoic acid receptor signaling pathway
GO:0051091 IEA:Ensembl P positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527 IEA:Ensembl P prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523 IEA:Ensembl P prostate epithelial cord elongation
GO:0042981 IEA:Ensembl P regulation of apoptotic process
GO:0060687 IEA:Ensembl P regulation of branching involved in prostate gland morphogenesis
GO:0032355 IEA:Ensembl P response to estradiol
GO:0060065 IEA:Ensembl P uterus development
GO:0060068 IEA:Ensembl P vagina development

KEGG Pathway Links

KEGG Pathway ID Description
ko04961 Endocrine and other factor-regulated calcium reabsorption
mcc04961 Endocrine and other factor-regulated calcium reabsorption
ko04915 Estrogen signaling pathway
mcc04915 Estrogen signaling pathway
ko04917 Prolactin signaling pathway
mcc04917 Prolactin signaling pathway
ko05205 Proteoglycans in cancer
mcc05205 Proteoglycans in cancer
mcc04919 Thyroid hormone signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001292 Oestrogen receptor
IPR024178 Oestrogen receptor/oestrogen-related receptor
IPR024736 Oestrogen-type nuclear receptor final C-terminal domain
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
estrogen receptor 1
Protein Entry
F6QUN5_MACMU
UniProt ID
F6QUN5
Species
Rhesus monkey

Comments

Comment Type Description
Function The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
Similarity Belongs to the nuclear hormone receptor family.
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily.
Similarity Contains nuclear receptor DNA-binding domain.
Subcellular Location Nucleus
Subunit Binds DNA as a homodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP014071 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
109072322 RefSeq XP_001097228 595 estrogen receptor 1

Identical Sequences to LMP014071 proteins

Reference Database Accession Length Protein Name
GI:109072322 RefSeq XP_005552208.1 595 PREDICTED: estrogen receptor isoform X1 [Macaca fascicularis]
GI:109072322 RefSeq XP_005552209.1 595 PREDICTED: estrogen receptor isoform X2 [Macaca fascicularis]
GI:109072322 RefSeq XP_005552210.1 595 PREDICTED: estrogen receptor isoform X3 [Macaca fascicularis]
GI:109072322 RefSeq XP_005552211.1 595 PREDICTED: estrogen receptor isoform X4 [Macaca fascicularis]

Related Sequences to LMP014071 proteins

Reference Database Accession Length Protein Name
GI:109072322 GenBank EHH18603.1 595 hypothetical protein EGK_15246 [Macaca mulatta]
GI:109072322 RefSeq XP_002803904.1 595 PREDICTED: estrogen receptor isoform 2 [Macaca mulatta]