LIPID MAPS

LMPD ID

LMP014206

Gene ID

698251

Species

Macaca mulatta (Rhesus monkey)

Gene Name

hexosaminidase A (alpha polypeptide)

Gene Symbol

HEXA

Alternate Names

beta-hexosaminidase subunit alpha; beta-hexosaminidase subunit alpha preproprotein;

Chromosome

7

Map Location

chromosome:7

EC Number

3.2.1.52

beta-hexosaminidase subunit alpha precursor
Refseq ID	NP_001248458
Protein GI	387849165
UniProt ID	F7GCB0
mRNA ID	NM_001261529
Length	529
Protein sequence is identical to GI:109081769 (mRNA isoform)
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2312 peptide sequence: MASSRLWFSLLLAAAFAGRATA


Refseq ID	XP_001092589
Protein GI	109081769
UniProt ID	F7GCB0
mRNA ID	XM_001092589
Length	529
MASSRLWFSLLLAAAFAGRATALWPWPQNIQTSDQRYVLYPNNFQFQYDISSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYRTGKRHTPEKNVLVVSVVTPGCNQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEISSVFPDFYLHLGGDEVDFTCWKSNPDIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIRPDTIIQVWREEIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLHVGYCEQEFEQT
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2312 peptide sequence: MASSRLWFSLLLAAAFAGRATA


Refseq ID	XP_002804897
Protein GI	297296816
UniProt ID	F7GCB0
mRNA ID	XM_001092589
Length	507
MASSRLWFSLLLAAAFAGRATALWPWPQNIQTSDQRYVLYPNNFQFQYDISSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYRTGKRHTPEKNYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEISSVFPDFYLHLGGDEVDFTCWKSNPDIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIRPDTIIQVWREEIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLHVGYCEQEFEQT
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2312 peptide sequence: MASSRLWFSLLLAAAFAGRATA


Refseq ID	XP_002804898
Protein GI	297296819
UniProt ID	F7GCB0
mRNA ID	XM_001092589
Length	540
MASSRLWFSLLLAAAFAGRATALWPWPQNIQTSDQRYVLYPNNFQFQYDISSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYRTGWPHQAYPVFPGKRHTPEKNVLVVSVVTPGCNQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEISSVFPDFYLHLGGDEVDFTCWKSNPDIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIRPDTIIQVWREEIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLHVGYCEQEFEQT
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2312 peptide sequence: MASSRLWFSLLLAAAFAGRATA

Entrez Gene ID

698251

Gene Name

hexosaminidase A (alpha polypeptide)

Gene Symbol

HEXA

Species

Macaca mulatta

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005764	IEA:Ensembl	C	lysosome
GO:0016020	IEA:Ensembl	C	membrane
GO:0004563	IEA:UniProtKB-EC	F	beta-N-acetylhexosaminidase activity
GO:0007628	IEA:Ensembl	P	adult walking behavior
GO:0005975	IEA:InterPro	P	carbohydrate metabolic process
GO:0048667	IEA:Ensembl	P	cell morphogenesis involved in neuron differentiation
GO:0006689	IEA:Ensembl	P	ganglioside catabolic process
GO:0030203	IEA:Ensembl	P	glycosaminoglycan metabolic process
GO:0019915	IEA:Ensembl	P	lipid storage
GO:0007040	IEA:Ensembl	P	lysosome organization
GO:0042552	IEA:Ensembl	P	myelination
GO:0050885	IEA:Ensembl	P	neuromuscular process controlling balance
GO:0050884	IEA:Ensembl	P	neuromuscular process controlling posture
GO:0007605	IEA:Ensembl	P	sensory perception of sound
GO:0019953	IEA:Ensembl	P	sexual reproduction
GO:0001501	IEA:Ensembl	P	skeletal system development

KEGG Pathway Links

KEGG Pathway ID	Description
ko00520	Amino sugar and nucleotide sugar metabolism
mcc00520	Amino sugar and nucleotide sugar metabolism
ko00531	Glycosaminoglycan degradation
mcc00531	Glycosaminoglycan degradation
ko00604	Glycosphingolipid biosynthesis - ganglio series
mcc00604	Glycosphingolipid biosynthesis - ganglio series
ko00603	Glycosphingolipid biosynthesis - globo series
mcc00603	Glycosphingolipid biosynthesis - globo series
M00079	Keratan sulfate degradation
mcc_M00079	Keratan sulfate degradation
ko04142	Lysosome
mcc04142	Lysosome
mcc01100	Metabolic pathways
ko00511	Other glycan degradation
mcc00511	Other glycan degradation

InterPro Annotations

Accession	Description
IPR029019	Beta-hexosaminidase, eukaryotic type, N-terminal
IPR025705	Beta_hexosaminidase_sua/sub
IPR029018	Chitobiase/beta-hexosaminidase domain 2-like
IPR015883	Glycoside hydrolase family 20, catalytic core
IPR017853	Glycoside hydrolase superfamily
IPR013781	Glycoside hydrolase, catalytic domain

Entry Information

Gene Name

hexosaminidase A (alpha polypeptide)

Protein Entry

F7GCB0_MACMU

UniProt ID

F7GCB0

Species

Rhesus monkey

Comments

Comment Type	Description
Catalytic Activity	Hydrolysis of terminal non-reducing N-acetyl- D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
Similarity	Belongs to the glycosyl hydrolase 20 family.

Unique RefSeq proteins for LMP014206 (as displayed in Record Overview)

Protein GI	Database	Accession	Length	Protein Name
297296819	RefSeq	XP_002804898	540	hexosaminidase A (alpha polypeptide)
109081769	RefSeq	XP_001092589	529	hexosaminidase A (alpha polypeptide)
297296816	RefSeq	XP_002804897	507	hexosaminidase A (alpha polypeptide)

Identical Sequences to LMP014206 proteins

Reference	Database	Accession	Length	Protein Name
GI:387849165	DBBJ	BAE01310.1	529	unnamed protein product [Macaca fascicularis]
GI:387849165	GenBank	AFE66324.1	529	beta-hexosaminidase subunit alpha preproprotein [Macaca mulatta]
GI:387849165	GenBank	AFI36970.1	529	beta-hexosaminidase subunit alpha preproprotein [Macaca mulatta]