Gene/Proteome Database (LMPD)

LMPD ID
LMP014216
Gene ID
705479
Species
Macaca mulatta (Rhesus monkey)
Gene Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Symbol
HMGCR
Alternate Names
3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase;
Chromosome
6
Map Location
chromosome:6

Proteins

Refseq ID XP_002804463
Protein GI 297294551
mRNA ID XM_002804417
Length 908
MQWMSYTRQRDAGSTDSVSTMLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLTLLLAVKYIFFEQAETESTLSLKNPITSPVVTQKKVPDNCCRREPVLVRNNQKCDSIEEETGINRERKVEVIKPLVAETDTPNKATFVVGNASLLDTSSVLVTQEPEIELPGEPRPNEECLQILGNTEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTDAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
Refseq ID XP_001104536
Protein GI 109077613
UniProt ID F7HJ02
mRNA ID XM_002804417
Length 835
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLTLLLAVKYIFFEQAETESTLSLKNPITSPVVTQKKVPDNCCRREPVLVRNNQKCDSIEEETGINRERKVEVIKPLVAETDTPNKATFVVGNASLLDTSSVLVTQEPEIELPGEPRPNEECLQILGNTEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTDAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
Refseq ID XP_001104607
Protein GI 109077611
UniProt ID F6PRW7
mRNA ID XM_002804417
Length 888
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLTLLLAVKYIFFEQAETESTLSLKNPITSPVVTQKKVPDNCCRREPVLVRNNQKCDSIEEETGINRERKVEVIKPLVAETDTPNKATFVVGNASLLDTSSVLVTQEPEIELPGEPRPNEECLQILGNTEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTDAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA

Gene Information

Entrez Gene ID
705479
Gene Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Symbol
HMGCR
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:InterPro C endoplasmic reticulum membrane
GO:0016021 IEA:InterPro C integral component of membrane
GO:0004420 IEA:InterPro F hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0050661 IEA:InterPro F NADP binding
GO:0015936 IEA:InterPro P coenzyme A metabolic process
GO:0008299 IEA:InterPro P isoprenoid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04152 AMPK signaling pathway
mcc04152 AMPK signaling pathway
ko04976 Bile secretion
mcc04976 Bile secretion
M00095 C5 isoprenoid biosynthesis, mevalonate pathway
mcc_M00095 C5 isoprenoid biosynthesis, mevalonate pathway
mcc01100 Metabolic pathways
ko00900 Terpenoid backbone biosynthesis
mcc00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain
IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain
IPR004816 Hydroxymethylglutaryl-CoA reductase, metazoan
IPR023282 Hydroxymethylglutaryl-CoA reductase, N-terminal
IPR000731 Sterol-sensing domain

UniProt Annotations

Entry Information

Gene Name
3-hydroxy-3-methylglutaryl-CoA reductase
Species
Rhesus monkey

Comments

Comment Type Description
Caution The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Similarity Belongs to the HMG-CoA reductase family.

Identical and Related Proteins

Unique RefSeq proteins for LMP014216 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
297294551 RefSeq XP_002804463 908
109077611 RefSeq XP_001104607 888 3-hydroxy-3-methylglutaryl-CoA reductase
109077613 RefSeq XP_001104536 835 3-hydroxy-3-methylglutaryl-CoA reductase

Identical Sequences to LMP014216 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP014216 proteins

Reference Database Accession Length Protein Name
GI:109077613 GenBank AAH33692.1 835 HMGCR protein [Homo sapiens]
GI:109077613 GenBank AFE78017.1 888 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1 [Macaca mulatta]
GI:109077613 RefSeq NP_001124468.1 835 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 2 [Homo sapiens]
GI:109077613 RefSeq XP_005557233.1 908 PREDICTED: 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform X1 [Macaca fascicularis]