Gene/Proteome Database (LMPD)

LMPD ID
LMP014563
Gene ID
709959
Species
Macaca mulatta (Rhesus monkey)
Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Gene Symbol
PIK3CA
Alternate Names
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphoinositide-3-kinase, catalytic, alpha polypeptide;
Chromosome
2
Map Location
chromosome:2

Proteins

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Refseq ID NP_001247597
Protein GI 386781258
UniProt ID H9FVU5
mRNA ID NM_001260668
Length 1068
Protein sequence is identical to GI:109043557 (mRNA isoform)
Refseq ID XP_001109162
Protein GI 109043557
UniProt ID H9FVU5
mRNA ID XM_001109162
Length 1068
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN

Gene Information

Entrez Gene ID
709959
Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Gene Symbol
PIK3CA
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030027 IEA:Ensembl C lamellipodium
GO:0005943 IEA:Ensembl C phosphatidylinositol 3-kinase complex, class IA
GO:0016303 IEA:Ensembl F 1-phosphatidylinositol-3-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0030295 IEA:Ensembl F protein kinase activator activity
GO:0006006 IEA:Ensembl P glucose metabolic process
GO:0044029 IEA:Ensembl P hypomethylation of CpG island
GO:2000811 IEA:Ensembl P negative regulation of anoikis
GO:2000270 IEA:Ensembl P negative regulation of fibroblast apoptotic process
GO:0043524 IEA:Ensembl P negative regulation of neuron apoptotic process
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling
GO:0033138 IEA:Ensembl P positive regulation of peptidyl-serine phosphorylation
GO:0043491 IEA:Ensembl P protein kinase B signaling
GO:0006468 IEA:Ensembl P protein phosphorylation
GO:2000653 IEA:Ensembl P regulation of genetic imprinting
GO:0040014 IEA:Ensembl P regulation of multicellular organism growth

KEGG Pathway Links

KEGG Pathway ID Description
ko04152 AMPK signaling pathway
mcc04152 AMPK signaling pathway
ko05221 Acute myeloid leukemia
mcc05221 Acute myeloid leukemia
ko04261 Adrenergic signaling in cardiomyocytes
mcc04261 Adrenergic signaling in cardiomyocytes
ko04960 Aldosterone-regulated sodium reabsorption
mcc04960 Aldosterone-regulated sodium reabsorption
ko05146 Amoebiasis
mcc05146 Amoebiasis
ko04210 Apoptosis
mcc04210 Apoptosis
ko04662 B cell receptor signaling pathway
mcc04662 B cell receptor signaling pathway
ko05100 Bacterial invasion of epithelial cells
mcc05100 Bacterial invasion of epithelial cells
ko04973 Carbohydrate digestion and absorption
mcc04973 Carbohydrate digestion and absorption
ko05142 Chagas disease (American trypanosomiasis)
mcc05142 Chagas disease (American trypanosomiasis)
ko04062 Chemokine signaling pathway
mcc04062 Chemokine signaling pathway
mcc04725 Cholinergic synapse
ko05220 Chronic myeloid leukemia
mcc05220 Chronic myeloid leukemia
ko05210 Colorectal cancer
mcc05210 Colorectal cancer
ko05213 Endometrial cancer
mcc05213 Endometrial cancer
ko05169 Epstein-Barr virus infection
mcc05169 Epstein-Barr virus infection
ko04012 ErbB signaling pathway
mcc04012 ErbB signaling pathway
ko04915 Estrogen signaling pathway
mcc04915 Estrogen signaling pathway
ko04664 Fc epsilon RI signaling pathway
mcc04664 Fc epsilon RI signaling pathway
ko04666 Fc gamma R-mediated phagocytosis
mcc04666 Fc gamma R-mediated phagocytosis
ko04510 Focal adhesion
mcc04510 Focal adhesion
mcc04068 FoxO signaling pathway
ko05214 Glioma
mcc05214 Glioma
mcc04066 HIF-1 signaling pathway
ko05166 HTLV-I infection
mcc05166 HTLV-I infection
mcc05161 Hepatitis B
ko05160 Hepatitis C
mcc05160 Hepatitis C
ko04750 Inflammatory mediator regulation of TRP channels
mcc04750 Inflammatory mediator regulation of TRP channels
ko05164 Influenza A
mcc05164 Influenza A
ko00562 Inositol phosphate metabolism
mcc00562 Inositol phosphate metabolism
ko04910 Insulin signaling pathway
mcc04910 Insulin signaling pathway
ko04630 Jak-STAT signaling pathway
mcc04630 Jak-STAT signaling pathway
ko04670 Leukocyte transendothelial migration
mcc04670 Leukocyte transendothelial migration
ko05162 Measles
mcc05162 Measles
ko05218 Melanoma
mcc05218 Melanoma
ko04650 Natural killer cell mediated cytotoxicity
mcc04650 Natural killer cell mediated cytotoxicity
ko04722 Neurotrophin signaling pathway
mcc04722 Neurotrophin signaling pathway
ko04932 Non-alcoholic fatty liver disease (NAFLD)
mcc04932 Non-alcoholic fatty liver disease (NAFLD)
ko05223 Non-small cell lung cancer
mcc05223 Non-small cell lung cancer
ko04380 Osteoclast differentiation
mcc04380 Osteoclast differentiation
ko04921 Oxytocin signaling pathway
mcc04921 Oxytocin signaling pathway
ko04151 PI3K-Akt signaling pathway
mcc04151 PI3K-Akt signaling pathway
ko05212 Pancreatic cancer
mcc05212 Pancreatic cancer
mcc05200 Pathways in cancer
ko04070 Phosphatidylinositol signaling system
mcc04070 Phosphatidylinositol signaling system
mcc04611 Platelet activation
ko04914 Progesterone-mediated oocyte maturation
mcc04914 Progesterone-mediated oocyte maturation
ko04917 Prolactin signaling pathway
mcc04917 Prolactin signaling pathway
ko05215 Prostate cancer
mcc05215 Prostate cancer
ko05205 Proteoglycans in cancer
mcc05205 Proteoglycans in cancer
ko04015 Rap1 signaling pathway
mcc04015 Rap1 signaling pathway
mcc04014 Ras signaling pathway
ko04810 Regulation of actin cytoskeleton
mcc04810 Regulation of actin cytoskeleton
ko05211 Renal cell carcinoma
mcc05211 Renal cell carcinoma
ko04550 Signaling pathways regulating pluripotency of stem cells
mcc04550 Signaling pathways regulating pluripotency of stem cells
ko05222 Small cell lung cancer
mcc05222 Small cell lung cancer
ko04660 T cell receptor signaling pathway
mcc04660 T cell receptor signaling pathway
ko04668 TNF signaling pathway
mcc04668 TNF signaling pathway
mcc04919 Thyroid hormone signaling pathway
ko04620 Toll-like receptor signaling pathway
mcc04620 Toll-like receptor signaling pathway
ko05145 Toxoplasmosis
mcc05145 Toxoplasmosis
ko04930 Type II diabetes mellitus
mcc04930 Type II diabetes mellitus
ko04370 VEGF signaling pathway
mcc04370 VEGF signaling pathway
ko05203 Viral carcinogenesis
mcc05203 Viral carcinogenesis
ko04024 cAMP signaling pathway
mcc04024 cAMP signaling pathway
ko04022 cGMP-PKG signaling pathway
mcc04022 cGMP-PKG signaling pathway
ko04150 mTOR signaling pathway
mcc04150 mTOR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain
IPR029071 Ubiquitin-related domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Protein Entry
H9FVU5_MACMU
UniProt ID
H9FVU5
Species
Rhesus monkey

Comments

Comment Type Description
Similarity Contains PI3K/PI4K domain.
Similarity Contains PIK helical domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP014563 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
109043557 RefSeq XP_001109162 1068 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Identical Sequences to LMP014563 proteins

Reference Database Accession Length Protein Name
GI:386781258 RefSeq XP_007970230.1 1068 PREDICTED: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [Chlorocebus sabaeus]
GI:386781258 RefSeq XP_009199591.1 1068 PREDICTED: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [Papio anubis]
GI:386781258 RefSeq XP_009199592.1 1068 PREDICTED: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [Papio anubis]
GI:386781258 RefSeq XP_009445164.1 1068 PREDICTED: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [Pan troglodytes]

Related Sequences to LMP014563 proteins

Reference Database Accession Length Protein Name
GI:386781258 PDB 4L23 1068 Chain A, Crystal Structure Of P110alpha Complexed With Nish2 Of P85alpha And Pi-103
GI:386781258 PDB 4L2Y 1068 Chain A, Crystal Structure Of P110alpha Complexed With Nish2 Of P85alpha And Compound 9d
GI:386781258 RefSeq XP_003894855.1 1068 PREDICTED: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [Papio anubis]
GI:386781258 SwissProt P42336.2 1068 RecName: Full=Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Short=PI3-kinase subunit alpha; Short=PI3K-alpha; Short=PI3Kalpha; Short=PtdIns-3-kinase subunit alpha; AltName: Full=Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Short=PtdIns-3-kinase subunit p110-alpha; Short=p110alpha; AltName: Full=Phosphoinositide-3-kinase catalytic alpha polypeptide; AltName: Full=Serine/threonine protein kinase PIK3CA [Homo sapiens]