Gene/Proteome Database (LMPD)

LMPD ID
LMP014605
Gene ID
718387
Species
Macaca mulatta (Rhesus monkey)
Gene Name
phospholipase C, beta 1 (phosphoinositide-specific)
Gene Symbol
PLCB1
Alternate Names
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1;
Chromosome
10
Map Location
chromosome:10
EC Number
3.1.4.11

Proteins

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
Refseq ID NP_001244796
Protein GI 383872394
UniProt ID F6ZKL2
mRNA ID NM_001257867
Length 1216
Protein sequence is identical to GI:109092853 (mRNA isoform)
Refseq ID XP_001116017
Protein GI 109092853
UniProt ID F6ZKL2
mRNA ID XM_001116017
Length 1216
MAGAQPGVHALQLKPVCVSDSLKKGIKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSFAKKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMELMYKILVKNKKKSHKSSEGSGKKKLSEQASNTCSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSETPSEVRTTPAENGVNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSSEELGGDIPGKEFDTPL

Gene Information

Entrez Gene ID
718387
Gene Name
phospholipase C, beta 1 (phosphoinositide-specific)
Gene Symbol
PLCB1
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:Ensembl C cytoplasm
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0000790 IEA:Ensembl C nuclear chromatin
GO:0016607 IEA:Ensembl C nuclear speck
GO:0005509 IEA:InterPro F calcium ion binding
GO:0005096 IEA:Ensembl F GTPase activator activity
GO:0005546 IEA:Ensembl F phosphatidylinositol-4,5-bisphosphate binding
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0060466 IEA:Ensembl P activation of meiosis involved in egg activation
GO:0021987 IEA:Ensembl P cerebral cortex development
GO:0045444 IEA:Ensembl P fat cell differentiation
GO:0007215 IEA:Ensembl P glutamate receptor signaling pathway
GO:0007213 IEA:Ensembl P G-protein coupled acetylcholine receptor signaling pathway
GO:0048009 IEA:Ensembl P insulin-like growth factor receptor signaling pathway
GO:0035722 IEA:Ensembl P interleukin-12-mediated signaling pathway
GO:0035723 IEA:Ensembl P interleukin-15-mediated signaling pathway
GO:0070498 IEA:Ensembl P interleukin-1-mediated signaling pathway
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0007613 IEA:Ensembl P memory
GO:2000438 IEA:Ensembl P negative regulation of monocyte extravasation
GO:0045892 IEA:Ensembl P negative regulation of transcription, DNA-templated
GO:2000344 IEA:Ensembl P positive regulation of acrosome reaction
GO:2000560 IEA:Ensembl P positive regulation of CD24 biosynthetic process
GO:0048639 IEA:Ensembl P positive regulation of developmental growth
GO:0040019 IEA:Ensembl P positive regulation of embryonic development
GO:1900087 IEA:Ensembl P positive regulation of G1/S transition of mitotic cell cycle
GO:0032735 IEA:Ensembl P positive regulation of interleukin-12 production
GO:0046330 IEA:Ensembl P positive regulation of JNK cascade
GO:0045663 IEA:Ensembl P positive regulation of myoblast differentiation
GO:0045893 IEA:Ensembl P positive regulation of transcription, DNA-templated
GO:0080154 IEA:Ensembl P regulation of fertilization
GO:0008277 IEA:Ensembl P regulation of G-protein coupled receptor protein signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
ko04261 Adrenergic signaling in cardiomyocytes
mcc04261 Adrenergic signaling in cardiomyocytes
ko05143 African trypanosomiasis
mcc05143 African trypanosomiasis
ko05010 Alzheimer's disease
mcc05010 Alzheimer's disease
ko05146 Amoebiasis
mcc05146 Amoebiasis
ko04020 Calcium signaling pathway
mcc04020 Calcium signaling pathway
ko04022 cGMP-PKG signaling pathway
mcc04022 cGMP-PKG signaling pathway
ko05142 Chagas disease (American trypanosomiasis)
mcc05142 Chagas disease (American trypanosomiasis)
ko04062 Chemokine signaling pathway
mcc04062 Chemokine signaling pathway
mcc04725 Cholinergic synapse
ko04713 Circadian entrainment
mcc04713 Circadian entrainment
ko04728 Dopaminergic synapse
mcc04728 Dopaminergic synapse
ko04961 Endocrine and other factor-regulated calcium reabsorption
mcc04961 Endocrine and other factor-regulated calcium reabsorption
ko04915 Estrogen signaling pathway
mcc04915 Estrogen signaling pathway
ko04540 Gap junction
mcc04540 Gap junction
ko04971 Gastric acid secretion
mcc04971 Gastric acid secretion
ko04724 Glutamatergic synapse
mcc04724 Glutamatergic synapse
ko04912 GnRH signaling pathway
mcc04912 GnRH signaling pathway
ko05016 Huntington's disease
mcc05016 Huntington's disease
ko04750 Inflammatory mediator regulation of TRP channels
mcc04750 Inflammatory mediator regulation of TRP channels
ko00562 Inositol phosphate metabolism
mcc00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
mcc_M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
mcc04911 Insulin secretion
ko04730 Long-term depression
mcc04730 Long-term depression
ko04720 Long-term potentiation
mcc04720 Long-term potentiation
ko04916 Melanogenesis
mcc04916 Melanogenesis
mcc01100 Metabolic pathways
ko04921 Oxytocin signaling pathway
mcc04921 Oxytocin signaling pathway
ko04972 Pancreatic secretion
mcc04972 Pancreatic secretion
ko04070 Phosphatidylinositol signaling system
mcc04070 Phosphatidylinositol signaling system
mcc04611 Platelet activation
ko04015 Rap1 signaling pathway
mcc04015 Rap1 signaling pathway
ko04723 Retrograde endocannabinoid signaling
mcc04723 Retrograde endocannabinoid signaling
ko04970 Salivary secretion
mcc04970 Salivary secretion
mcc04726 Serotonergic synapse
mcc04919 Thyroid hormone signaling pathway
ko04918 Thyroid hormone synthesis
mcc04918 Thyroid hormone synthesis
ko04270 Vascular smooth muscle contraction
mcc04270 Vascular smooth muscle contraction
ko04310 Wnt signaling pathway
mcc04310 Wnt signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028400 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR014815 PLC-beta, C-terminal
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, beta 1 (phosphoinositide-specific)
Protein Entry
F6ZKL2_MACMU
UniProt ID
F6ZKL2
Species
Rhesus monkey

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Similarity Contains 1 C2 domain.
Similarity Contains 1 PI-PLC X-box domain.
Similarity Contains 1 PI-PLC Y-box domain.
Similarity Contains C2 domain.
Similarity Contains Cdomain.
Similarity Contains PI-PLC X-box domain.
Similarity Contains PI-PLC Y-box domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP014605 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
109092853 RefSeq XP_001116017 1216 phospholipase C, beta 1 (phosphoinositide-specific)

Identical Sequences to LMP014605 proteins

Reference Database Accession Length Protein Name
GI:383872394 GenBank AFE77368.1 1216 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 isoform a [Macaca mulatta]
GI:383872394 RefSeq XP_005568429.1 1216 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [Macaca fascicularis]

Related Sequences to LMP014605 proteins

Reference Database Accession Length Protein Name
GI:383872394 GenBank ADT41868.1 1216 Sequence 814 from patent US 7833706
GI:383872394 RefSeq XP_008016575.1 1216 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [Chlorocebus sabaeus]