Gene/Proteome Database (LMPD)

LMPD ID
LMP014606
Gene ID
701951
Species
Macaca mulatta (Rhesus monkey)
Gene Name
phospholipase C, beta 2
Gene Symbol
PLCB2
Alternate Names
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2;
Chromosome
7
Map Location
chromosome:7
EC Number
3.1.4.11

Proteins

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2
Refseq ID NP_001253955
Protein GI 388452734
UniProt ID H9YV70
mRNA ID NM_001267026
Length 1185
Protein sequence is identical to GI:297296150 (mRNA isoform)
Refseq ID XP_001095135
Protein GI 297296150
UniProt ID H9YV70
mRNA ID XM_001095135
Length 1185
MSLLNPVLLPPRVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKVWAEDILALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEINEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSSPTSSSKDPGGEAEGSSPRSAPAGEGTVWAGEEGTELEDEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILVPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFVFLEMKDYVPGAWADLTVALANPIKFFSAHDKRSVKLKDIMGGLPEKPFPLASPVASQVNGALAPRSNGSPAARAWAREEAMKEVAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPRGAGGGGAGKLGPGKGSRKKRSLPCEESAGAAPGESPEGMDARVRELKDRLELELLRQGEEQYECVLKRKEQHAAEQISKMMELAREKQAAELKALKETAEIDTKEMKKKLETKRLERIQGMTKVTADKMAQERLKREINSSHIQEVVQVIKQMTENLEKHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACFRTCFPSETKDKPERDCECPPELCEQDPVVAKTDVQESRL
Refseq ID XP_002804767
Protein GI 297296148
UniProt ID H9YV70
mRNA ID XM_001095135
Length 1170
MSLLNPVLLPPRVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKVWAEDILALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEINEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSSPTSSSKDPGGEAEGSSPRSAPAGEGTVWAGEEGTELEDEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILVPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFVFLEMKDYVPGAWADLTVALANPIKFFSAHDKRSVKLKDIMGGLPEKPFPLASPVASQVNGALAPRSNGSPEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPRGAGGGGAGKLGPGKGSRKKRSLPCEESAGAAPGESPEGMDARVRELKDRLELELLRQGEEQYECVLKRKEQHAAEQISKMMELAREKQAAELKALKETAEIDTKEMKKKLETKRLERIQGMTKVTADKMAQERLKREINSSHIQEVVQVIKQMTENLEKHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACFRTCFPSETKDKPERDCECPPELCEQDPVVAKTDVQESRL

Gene Information

Entrez Gene ID
701951
Gene Name
phospholipase C, beta 2
Gene Symbol
PLCB2
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04261 Adrenergic signaling in cardiomyocytes
mcc04261 Adrenergic signaling in cardiomyocytes
ko05143 African trypanosomiasis
mcc05143 African trypanosomiasis
ko05010 Alzheimer's disease
mcc05010 Alzheimer's disease
ko05146 Amoebiasis
mcc05146 Amoebiasis
ko04020 Calcium signaling pathway
mcc04020 Calcium signaling pathway
ko05142 Chagas disease (American trypanosomiasis)
mcc05142 Chagas disease (American trypanosomiasis)
ko04062 Chemokine signaling pathway
mcc04062 Chemokine signaling pathway
mcc04725 Cholinergic synapse
ko04713 Circadian entrainment
mcc04713 Circadian entrainment
ko04728 Dopaminergic synapse
mcc04728 Dopaminergic synapse
ko04961 Endocrine and other factor-regulated calcium reabsorption
mcc04961 Endocrine and other factor-regulated calcium reabsorption
ko04915 Estrogen signaling pathway
mcc04915 Estrogen signaling pathway
ko04540 Gap junction
mcc04540 Gap junction
ko04971 Gastric acid secretion
mcc04971 Gastric acid secretion
ko04724 Glutamatergic synapse
mcc04724 Glutamatergic synapse
ko04912 GnRH signaling pathway
mcc04912 GnRH signaling pathway
ko05016 Huntington's disease
mcc05016 Huntington's disease
ko04750 Inflammatory mediator regulation of TRP channels
mcc04750 Inflammatory mediator regulation of TRP channels
ko00562 Inositol phosphate metabolism
mcc00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
mcc_M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
mcc04911 Insulin secretion
ko04730 Long-term depression
mcc04730 Long-term depression
ko04720 Long-term potentiation
mcc04720 Long-term potentiation
ko04916 Melanogenesis
mcc04916 Melanogenesis
mcc01100 Metabolic pathways
ko04921 Oxytocin signaling pathway
mcc04921 Oxytocin signaling pathway
ko04972 Pancreatic secretion
mcc04972 Pancreatic secretion
ko04070 Phosphatidylinositol signaling system
mcc04070 Phosphatidylinositol signaling system
mcc04611 Platelet activation
ko04015 Rap1 signaling pathway
mcc04015 Rap1 signaling pathway
ko04723 Retrograde endocannabinoid signaling
mcc04723 Retrograde endocannabinoid signaling
ko04970 Salivary secretion
mcc04970 Salivary secretion
mcc04726 Serotonergic synapse
mcc04919 Thyroid hormone signaling pathway
ko04918 Thyroid hormone synthesis
mcc04918 Thyroid hormone synthesis
ko04270 Vascular smooth muscle contraction
mcc04270 Vascular smooth muscle contraction
ko04310 Wnt signaling pathway
mcc04310 Wnt signaling pathway
ko04022 cGMP-PKG signaling pathway
mcc04022 cGMP-PKG signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028403 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR014815 PLC-beta, C-terminal
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like

UniProt Annotations

Entry Information

Gene Name
phospholipase C, beta 2
Protein Entry
H9YV70_MACMU
UniProt ID
H9YV70
Species
Rhesus monkey

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Similarity Contains 1 C2 domain.
Similarity Contains 1 PI-PLC X-box domain.
Similarity Contains 1 PI-PLC Y-box domain.
Similarity Contains C2 domain.
Similarity Contains Cdomain.
Similarity Contains PI-PLC X-box domain.
Similarity Contains PI-PLC Y-box domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP014606 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
297296150 RefSeq XP_001095135 1185 phospholipase C, beta 2
297296148 RefSeq XP_002804767 1170 phospholipase C, beta 2

Identical Sequences to LMP014606 proteins

Reference Database Accession Length Protein Name
GI:388452734 GenBank AFH27586.1 1185 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 [Macaca mulatta]

Related Sequences to LMP014606 proteins

Reference Database Accession Length Protein Name
GI:388452734 GenBank AFH32826.1 1181 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 [Macaca mulatta]
GI:388452734 RefSeq XP_003900813.1 1185 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [Papio anubis]
GI:388452734 RefSeq XP_005559223.1 1185 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [Macaca fascicularis]