Gene/Proteome Database (LMPD)

LMPD ID
LMP014614
Gene ID
714173
Species
Macaca mulatta (Rhesus monkey)
Gene Name
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Gene Symbol
PLCG2
Alternate Names
phospholipase C, gamma 2 (phosphatidylinositol-specific);
Chromosome
20
Map Location
chromosome:20
EC Number
3.1.4.11

Proteins

Refseq ID XP_001111717
Protein GI 109129322
UniProt ID F7GH26
mRNA ID XM_001111717
Length 1265
MSTMVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDALNWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDKFVEIGAHRDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLSKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIKEHAFVTSSFPVILSIEEHCSVEQQRHMAKTFKEVFGDLLLMKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTTEEEVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYESLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTKIQQYFPSNYVEDISTADVEELEKQIIEDNPLGCLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSITRQKPVDLLRYNQKGLTRIYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKFMQMNHALFSLNGRTGYVLQPESMRAEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGADYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNKRLREKRVSNSKFYS

Gene Information

Entrez Gene ID
714173
Gene Name
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Gene Symbol
PLCG2
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005886 ISS:UniProtKB C plasma membrane
GO:0004435 ISS:UniProtKB F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0050853 IEA:Ensembl P B cell receptor signaling pathway
GO:0050852 IEA:Ensembl P T cell receptor signaling pathway
GO:0032237 IEA:Ensembl P activation of store-operated calcium channel activity
GO:0002316 IEA:Ensembl P follicular B cell differentiation
GO:0032959 IEA:Ensembl P inositol trisphosphate biosynthetic process
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0043069 IEA:Ensembl P negative regulation of programmed cell death
GO:0006661 ISS:UniProtKB P phosphatidylinositol biosynthetic process
GO:0009395 IEA:InterPro P phospholipid catabolic process
GO:0010468 IEA:Ensembl P regulation of gene expression
GO:0051209 ISS:UniProtKB P release of sequestered calcium ion into cytosol
GO:0032496 IEA:Ensembl P response to lipopolysaccharide

KEGG Pathway Links

KEGG Pathway ID Description
ko04662 B cell receptor signaling pathway
mcc04662 B cell receptor signaling pathway
ko04020 Calcium signaling pathway
mcc04020 Calcium signaling pathway
ko05169 Epstein-Barr virus infection
mcc05169 Epstein-Barr virus infection
ko04012 ErbB signaling pathway
mcc04012 ErbB signaling pathway
ko04664 Fc epsilon RI signaling pathway
mcc04664 Fc epsilon RI signaling pathway
ko04666 Fc gamma R-mediated phagocytosis
mcc04666 Fc gamma R-mediated phagocytosis
ko05214 Glioma
mcc05214 Glioma
mcc04066 HIF-1 signaling pathway
ko04750 Inflammatory mediator regulation of TRP channels
mcc04750 Inflammatory mediator regulation of TRP channels
ko00562 Inositol phosphate metabolism
mcc00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
mcc_M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
ko04670 Leukocyte transendothelial migration
mcc04670 Leukocyte transendothelial migration
mcc01100 Metabolic pathways
ko05206 MicroRNAs in cancer
mcc05206 MicroRNAs in cancer
mcc04064 NF-kappa B signaling pathway
ko04650 Natural killer cell mediated cytotoxicity
mcc04650 Natural killer cell mediated cytotoxicity
ko04722 Neurotrophin signaling pathway
mcc04722 Neurotrophin signaling pathway
ko05223 Non-small cell lung cancer
mcc05223 Non-small cell lung cancer
ko04380 Osteoclast differentiation
mcc04380 Osteoclast differentiation
mcc05200 Pathways in cancer
ko04070 Phosphatidylinositol signaling system
mcc04070 Phosphatidylinositol signaling system
mcc04611 Platelet activation
ko05205 Proteoglycans in cancer
mcc05205 Proteoglycans in cancer
mcc04014 Ras signaling pathway
mcc04919 Thyroid hormone signaling pathway
ko04370 VEGF signaling pathway
mcc04370 VEGF signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028381 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
IPR000008 C2 domain
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain
IPR000980 SH2 domain
IPR001452 SH3_domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Protein Entry
F7GH26_MACMU
UniProt ID
F7GH26
Species
Rhesus monkey

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Caution The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Similarity Contains 1 C2 domain.
Similarity Contains 1 PI-PLC X-box domain.
Similarity Contains 1 PI-PLC Y-box domain.
Similarity Contains 1 SH3 domain.
Similarity Contains 2 PH domains.
Similarity Contains C2 domain.
Similarity Contains Cdomain.
Similarity Contains PH domain.
Similarity Contains PI-PLC X-box domain.
Similarity Contains PI-PLC Y-box domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP014614 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
109129322 RefSeq XP_001111717 1265 phospholipase C, gamma 2 (phosphatidylinositol-specific)

Identical Sequences to LMP014614 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP014614 proteins

Reference Database Accession Length Protein Name
GI:109129322 GenBank EHH31893.1 1265 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 [Macaca mulatta]
GI:109129322 GenBank EHH60606.1 1265 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 [Macaca fascicularis]
GI:109129322 RefSeq XP_005592695.1 1265 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [Macaca fascicularis]
GI:109129322 RefSeq XP_009195205.1 1265 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [Papio anubis]