Gene/Proteome Database (LMPD)

LMPD ID
LMP014687
Gene ID
695558
Species
Macaca mulatta (Rhesus monkey)
Gene Name
protein kinase, AMP-activated, alpha 1 catalytic subunit
Gene Symbol
PRKAA1
Alternate Names
protein kinase, AMP-activated, alpha 1 catalytic subunit;
Chromosome
6
Map Location
chromosome:6

Proteins

Refseq ID XP_001086285
Protein GI 109077066
UniProt ID F7HR74
mRNA ID XM_001086285
Length 574
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPRVVKTGSMKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLSRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
Refseq ID XP_001086410
Protein GI 297294191
UniProt ID F7HR74
mRNA ID XM_001086285
Length 559
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLSRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

Gene Information

Entrez Gene ID
695558
Gene Name
protein kinase, AMP-activated, alpha 1 catalytic subunit
Gene Symbol
PRKAA1
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031588 IEA:InterPro C AMP-activated protein kinase complex
GO:0005737 IEA:Ensembl C cytoplasm
GO:0005634 IEA:Ensembl C nucleus
GO:0004679 IEA:Ensembl F AMP-activated protein kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003682 IEA:Ensembl F chromatin binding
GO:0035174 IEA:Ensembl F histone serine kinase activity
GO:0000187 IEA:InterPro P activation of MAPK activity
GO:0042149 IEA:Ensembl P cellular response to glucose starvation
GO:0019395 IEA:Ensembl P fatty acid oxidation
GO:0042593 IEA:Ensembl P glucose homeostasis
GO:0006006 IEA:Ensembl P glucose metabolic process
GO:0008610 IEA:Ensembl P lipid biosynthetic process
GO:0032007 IEA:Ensembl P negative regulation of TOR signaling
GO:0043066 IEA:Ensembl P negative regulation of apoptotic process
GO:0050995 IEA:Ensembl P negative regulation of lipid catabolic process
GO:0010508 IEA:Ensembl P positive regulation of autophagy
GO:0010628 IEA:Ensembl P positive regulation of gene expression
GO:0042752 IEA:Ensembl P regulation of circadian rhythm
GO:0009411 IEA:Ensembl P response to UV
GO:1901563 IEA:Ensembl P response to camptothecin
GO:0010332 IEA:Ensembl P response to gamma radiation
GO:0042542 IEA:Ensembl P response to hydrogen peroxide

KEGG Pathway Links

KEGG Pathway ID Description
ko04152 AMPK signaling pathway
mcc04152 AMPK signaling pathway
ko04920 Adipocytokine signaling pathway
mcc04920 Adipocytokine signaling pathway
ko04710 Circadian rhythm
mcc04710 Circadian rhythm
mcc04068 FoxO signaling pathway
ko05410 Hypertrophic cardiomyopathy (HCM)
mcc05410 Hypertrophic cardiomyopathy (HCM)
ko04910 Insulin signaling pathway
mcc04910 Insulin signaling pathway
ko04932 Non-alcoholic fatty liver disease (NAFLD)
mcc04932 Non-alcoholic fatty liver disease (NAFLD)
ko04921 Oxytocin signaling pathway
mcc04921 Oxytocin signaling pathway
ko04151 PI3K-Akt signaling pathway
mcc04151 PI3K-Akt signaling pathway
ko04140 Regulation of autophagy
mcc04140 Regulation of autophagy
ko04150 mTOR signaling pathway
mcc04150 mTOR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028797 5'-AMP-activated protein kinase catalytic subunit alpha-1
IPR028375 KA1 domain/Ssp2 C-terminal domain
IPR000719 Protein kinase domain
IPR017441 Protein kinase, ATP binding site
IPR011009 Protein kinase-like domain
IPR008271 Serine/threonine-protein kinase, active site
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
protein kinase, AMP-activated, alpha 1 catalytic subunit
Protein Entry
F7HR74_MACMU
UniProt ID
F7HR74
Species
Rhesus monkey

Comments

Comment Type Description
Catalytic Activity ATP + a protein = ADP + a phosphoprotein.
Caution The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Similarity Contains protein kinase domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP014687 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
109077066 RefSeq XP_001086285 574 protein kinase, AMP-activated, alpha 1 catalytic subunit
297294191 RefSeq XP_001086410 559 protein kinase, AMP-activated, alpha 1 catalytic subunit

Identical Sequences to LMP014687 proteins

Reference Database Accession Length Protein Name
GI:109077066 RefSeq XP_005556844.1 574 PREDICTED: 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [Macaca fascicularis]
GI:297294191 RefSeq XP_005556845.1 559 PREDICTED: 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2 [Macaca fascicularis]
GI:297294191 RefSeq XP_007959659.1 559 PREDICTED: 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [Chlorocebus sabaeus]
GI:297294191 RefSeq XP_003899658.2 559 PREDICTED: 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [Papio anubis]

Related Sequences to LMP014687 proteins

Reference Database Accession Length Protein Name
GI:297294191 RefSeq NP_996790.3 574 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 2 [Homo sapiens]
GI:297294191 RefSeq XP_003274422.1 559 PREDICTED: 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1 [Nomascus leucogenys]
GI:297294191 RefSeq XP_009238944.1 574 PREDICTED: 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [Pongo abelii]
GI:297294191 RefSeq XP_009447514.1 574 PREDICTED: LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-1 [Pan troglodytes]