Gene/Proteome Database (LMPD)

LMPD ID
LMP014693
Gene ID
718412
Species
Macaca mulatta (Rhesus monkey)
Gene Name
protein kinase C, alpha
Gene Symbol
PRKCA
Alternate Names
protein kinase C alpha type;
Chromosome
16
Map Location
chromosome:16
EC Number
2.7.11.13

Proteins

protein kinase C alpha type
Refseq ID NP_001247662
Protein GI 386781719
UniProt ID F7H1C6
mRNA ID NM_001260733
Length 672
Protein sequence is identical to GI:297273437 (mRNA isoform)
Refseq ID XP_002800615
Protein GI 297273437
UniProt ID F7H1C6
mRNA ID XM_002800569
Length 672
MADVFPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV

Gene Information

Entrez Gene ID
718412
Gene Name
protein kinase C, alpha
Gene Symbol
PRKCA
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0045177 IEA:Ensembl C apical part of cell
GO:0005829 IEA:Ensembl C cytosol
GO:0030425 IEA:Ensembl C dendrite
GO:0005783 IEA:Ensembl C endoplasmic reticulum
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IEA:Ensembl C mitochondrion
GO:0043025 IEA:Ensembl C neuronal cell body
GO:0005634 IEA:Ensembl C nucleus
GO:0001750 IEA:Ensembl C photoreceptor outer segment
GO:0005886 IEA:Ensembl C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004698 IEA:Ensembl F calcium-dependent protein kinase C activity
GO:0035403 IEA:Ensembl F histone kinase activity (H3-T6 specific)
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006874 IEA:Ensembl P cellular calcium ion homeostasis
GO:0071322 IEA:Ensembl P cellular response to carbohydrate stimulus
GO:0002062 IEA:Ensembl P chondrocyte differentiation
GO:0002159 IEA:Ensembl P desmosome assembly
GO:0000188 IEA:Ensembl P inactivation of MAPK activity
GO:0050930 IEA:Ensembl P induction of positive chemotaxis
GO:0097193 IEA:Ensembl P intrinsic apoptotic signaling pathway
GO:0008285 IEA:Ensembl P negative regulation of cell proliferation
GO:0034351 IEA:Ensembl P negative regulation of glial cell apoptotic process
GO:0046325 IEA:Ensembl P negative regulation of glucose import
GO:0046627 IEA:Ensembl P negative regulation of insulin receptor signaling pathway
GO:0030593 IEA:Ensembl P neutrophil chemotaxis
GO:0036289 IEA:Ensembl P peptidyl-serine autophosphorylation
GO:0045766 IEA:Ensembl P positive regulation of angiogenesis
GO:0043536 IEA:Ensembl P positive regulation of blood vessel endothelial cell migration
GO:0045785 IEA:Ensembl P positive regulation of cell adhesion
GO:0001938 IEA:Ensembl P positive regulation of endothelial cell proliferation
GO:0050729 IEA:Ensembl P positive regulation of inflammatory response
GO:0031666 IEA:Ensembl P positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045931 IEA:Ensembl P positive regulation of mitotic cell cycle
GO:0001934 IEA:Ensembl P positive regulation of protein phosphorylation
GO:0006937 IEA:Ensembl P regulation of muscle contraction
GO:0050730 IEA:Ensembl P regulation of peptidyl-tyrosine phosphorylation
GO:0090330 IEA:Ensembl P regulation of platelet aggregation
GO:0002026 IEA:Ensembl P regulation of the force of heart contraction
GO:0070555 IEA:Ensembl P response to interleukin-1

KEGG Pathway Links

KEGG Pathway ID Description
ko05143 African trypanosomiasis
mcc05143 African trypanosomiasis
ko04960 Aldosterone-regulated sodium reabsorption
mcc04960 Aldosterone-regulated sodium reabsorption
ko05146 Amoebiasis
mcc05146 Amoebiasis
ko05031 Amphetamine addiction
mcc05031 Amphetamine addiction
ko04020 Calcium signaling pathway
mcc04020 Calcium signaling pathway
mcc04725 Cholinergic synapse
ko04713 Circadian entrainment
mcc04713 Circadian entrainment
ko04728 Dopaminergic synapse
mcc04728 Dopaminergic synapse
ko04961 Endocrine and other factor-regulated calcium reabsorption
mcc04961 Endocrine and other factor-regulated calcium reabsorption
ko04012 ErbB signaling pathway
mcc04012 ErbB signaling pathway
ko04666 Fc gamma R-mediated phagocytosis
mcc04666 Fc gamma R-mediated phagocytosis
ko04510 Focal adhesion
mcc04510 Focal adhesion
ko04727 GABAergic synapse
mcc04727 GABAergic synapse
ko04540 Gap junction
mcc04540 Gap junction
ko04971 Gastric acid secretion
mcc04971 Gastric acid secretion
ko05214 Glioma
mcc05214 Glioma
ko04724 Glutamatergic synapse
mcc04724 Glutamatergic synapse
mcc04066 HIF-1 signaling pathway
mcc05161 Hepatitis B
ko04750 Inflammatory mediator regulation of TRP channels
mcc04750 Inflammatory mediator regulation of TRP channels
mcc04911 Insulin secretion
ko04670 Leukocyte transendothelial migration
mcc04670 Leukocyte transendothelial migration
ko04730 Long-term depression
mcc04730 Long-term depression
ko04720 Long-term potentiation
mcc04720 Long-term potentiation
ko04010 MAPK signaling pathway
mcc04010 MAPK signaling pathway
ko04916 Melanogenesis
mcc04916 Melanogenesis
ko05206 MicroRNAs in cancer
mcc05206 MicroRNAs in cancer
ko05032 Morphine addiction
mcc05032 Morphine addiction
ko04650 Natural killer cell mediated cytotoxicity
mcc04650 Natural killer cell mediated cytotoxicity
ko05223 Non-small cell lung cancer
mcc05223 Non-small cell lung cancer
ko04921 Oxytocin signaling pathway
mcc04921 Oxytocin signaling pathway
ko04972 Pancreatic secretion
mcc04972 Pancreatic secretion
mcc05200 Pathways in cancer
ko04070 Phosphatidylinositol signaling system
mcc04070 Phosphatidylinositol signaling system
ko05205 Proteoglycans in cancer
mcc05205 Proteoglycans in cancer
ko04015 Rap1 signaling pathway
mcc04015 Rap1 signaling pathway
mcc04014 Ras signaling pathway
ko04723 Retrograde endocannabinoid signaling
mcc04723 Retrograde endocannabinoid signaling
ko04970 Salivary secretion
mcc04970 Salivary secretion
mcc04726 Serotonergic synapse
mcc04919 Thyroid hormone signaling pathway
ko04918 Thyroid hormone synthesis
mcc04918 Thyroid hormone synthesis
ko04530 Tight junction
mcc04530 Tight junction
ko04370 VEGF signaling pathway
mcc04370 VEGF signaling pathway
ko04270 Vascular smooth muscle contraction
mcc04270 Vascular smooth muscle contraction
ko04310 Wnt signaling pathway
mcc04310 Wnt signaling pathway
ko04150 mTOR signaling pathway
mcc04150 mTOR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR000961 AGC-kinase, C-terminal
IPR000008 C2 domain
IPR020454 Diacylglycerol/phorbol-ester binding
IPR014375 Protein kinase C, alpha/beta/gamma types
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR000719 Protein kinase domain
IPR017441 Protein kinase, ATP binding site
IPR017892 Protein kinase, C-terminal
IPR011009 Protein kinase-like domain
IPR008271 Serine/threonine-protein kinase, active site
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
protein kinase C, alpha
Protein Entry
F7H1C6_MACMU
UniProt ID
F7H1C6
Species
Rhesus monkey

Comments

Comment Type Description
Catalytic Activity ATP + a protein = ADP + a phosphoprotein.
Similarity Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity Contains 1 C2 domain.
Similarity Contains AGC-kinase C-terminal domain.
Similarity Contains protein kinase domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP014693 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
297273437 RefSeq XP_002800615 672 protein kinase C, alpha

Identical Sequences to LMP014693 proteins

Reference Database Accession Length Protein Name
GI:386781719 GenBank AFE63693.1 672 protein kinase C alpha type [Macaca mulatta]
GI:386781719 RefSeq XP_005584797.1 672 PREDICTED: protein kinase C alpha type isoform X2 [Macaca fascicularis]
GI:386781719 RefSeq XP_008010230.1 672 PREDICTED: protein kinase C alpha type isoform X1 [Chlorocebus sabaeus]
GI:386781719 RefSeq XP_010378287.1 672 PREDICTED: protein kinase C alpha type [Rhinopithecus roxellana]

Related Sequences to LMP014693 proteins

Reference Database Accession Length Protein Name
GI:386781719 GenBank AFE63692.1 672 protein kinase C alpha type [Macaca mulatta]