Gene/Proteome Database (LMPD)

LMPD ID
LMP014826
Gene ID
716553
Species
Macaca mulatta (Rhesus monkey)
Gene Name
sonic hedgehog
Gene Symbol
SHH
Alternate Names
sonic hedgehog; sonic hedgehog homolog;
Chromosome
3
Map Location
chromosome:3

Proteins

Refseq ID XP_001106515
Protein GI 297289745
UniProt ID F7E9N5
mRNA ID XM_001106515
Length 465
MGEMLLLARCLLLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDFLTFLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSAAAEPEAFSGAGPPFEGALGHRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLREEAAGAYAPLTAQGTILINRVLASCYAVIEEHGWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGSRVPPPAPGAADATGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS

Gene Information

Entrez Gene ID
716553
Gene Name
sonic hedgehog
Gene Symbol
SHH
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IEA:Ensembl C cell surface
GO:0031012 IEA:Ensembl C extracellular matrix
GO:0005615 IEA:Ensembl C extracellular space
GO:0045121 IEA:Ensembl C membrane raft
GO:0005634 IEA:Ensembl C nucleus
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0005509 IEA:Ensembl F calcium ion binding
GO:0005539 IEA:Ensembl F glycosaminoglycan binding
GO:0008233 IEA:UniProtKB-KW F peptidase activity
GO:0008270 IEA:Ensembl F zinc ion binding
GO:0008209 IEA:Ensembl P androgen metabolic process
GO:0097190 IEA:Ensembl P apoptotic signaling pathway
GO:0060840 IEA:Ensembl P artery development
GO:0007411 IEA:Ensembl P axon guidance
GO:0060020 IEA:Ensembl P Bergmann glial cell differentiation
GO:0007596 IEA:Ensembl P blood coagulation
GO:0060445 IEA:Ensembl P branching involved in salivary gland morphogenesis
GO:0001658 IEA:Ensembl P branching involved in ureteric bud morphogenesis
GO:0060447 IEA:Ensembl P bud outgrowth involved in lung branching
GO:0043010 IEA:Ensembl P camera-type eye development
GO:0060070 IEA:Ensembl P canonical Wnt signaling pathway
GO:0043369 IEA:Ensembl P CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0001708 IEA:Ensembl P cell fate specification
GO:0071285 IEA:Ensembl P cellular response to lithium ion
GO:0021930 IEA:Ensembl P cerebellar granule cell precursor proliferation
GO:0003140 IEA:Ensembl P determination of left/right asymmetry in lateral mesoderm
GO:0021904 IEA:Ensembl P dorsal/ventral neural tube patterning
GO:0007398 IEA:Ensembl P ectoderm development
GO:0048557 IEA:Ensembl P embryonic digestive tract morphogenesis
GO:0042733 IEA:Ensembl P embryonic digit morphogenesis
GO:0048617 IEA:Ensembl P embryonic foregut morphogenesis
GO:0035115 IEA:Ensembl P embryonic forelimb morphogenesis
GO:0035116 IEA:Ensembl P embryonic hindlimb morphogenesis
GO:0048706 IEA:Ensembl P embryonic skeletal system development
GO:0006897 IEA:Ensembl P endocytosis
GO:0060664 IEA:Ensembl P epithelial cell proliferation involved in salivary gland morphogenesis
GO:0030010 IEA:Ensembl P establishment of cell polarity
GO:0048859 IEA:Ensembl P formation of anatomical boundary
GO:0031069 IEA:Ensembl P hair follicle morphogenesis
GO:0001947 IEA:Ensembl P heart looping
GO:0007442 IEA:Ensembl P hindgut morphogenesis
GO:0048839 IEA:Ensembl P inner ear development
GO:0016539 IEA:InterPro P intein-mediated protein splicing
GO:0045109 IEA:Ensembl P intermediate filament organization
GO:0060459 IEA:Ensembl P left lung development
GO:0060174 IEA:Ensembl P limb bud formation
GO:0060484 IEA:Ensembl P lung-associated mesenchyme development
GO:0060428 IEA:Ensembl P lung epithelium development
GO:0060463 IEA:Ensembl P lung lobe morphogenesis
GO:0002320 IEA:Ensembl P lymphoid progenitor cell differentiation
GO:0030539 IEA:Ensembl P male genitalia development
GO:0060916 IEA:Ensembl P mesenchymal cell proliferation involved in lung development
GO:0060783 IEA:Ensembl P mesenchymal smoothened signaling pathway involved in prostate gland development
GO:0072136 IEA:Ensembl P metanephric mesenchymal cell proliferation involved in metanephros development
GO:0030901 IEA:Ensembl P midbrain development
GO:0080125 IEA:Ensembl P multicellular structure septum development
GO:0045445 IEA:Ensembl P myoblast differentiation
GO:0014902 IEA:Ensembl P myotube differentiation
GO:0046639 IEA:Ensembl P negative regulation of alpha-beta T cell differentiation
GO:0090090 IEA:Ensembl P negative regulation of canonical Wnt signaling pathway
GO:0030336 IEA:Ensembl P negative regulation of cell migration
GO:0090370 IEA:Ensembl P negative regulation of cholesterol efflux
GO:2000357 IEA:Ensembl P negative regulation of kidney smooth muscle cell differentiation
GO:2001054 IEA:Ensembl P negative regulation of mesenchymal cell apoptotic process
GO:0032435 IEA:Ensembl P negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042130 IEA:Ensembl P negative regulation of T cell proliferation
GO:0034244 IEA:Ensembl P negative regulation of transcription elongation from RNA polymerase II promoter
GO:0000122 IEA:Ensembl P negative regulation of transcription from RNA polymerase II promoter
GO:2000062 IEA:Ensembl P negative regulation of ureter smooth muscle cell differentiation
GO:0045060 IEA:Ensembl P negative thymic T cell selection
GO:0001755 IEA:Ensembl P neural crest cell migration
GO:0007405 IEA:Ensembl P neuroblast proliferation
GO:0048663 IEA:Ensembl P neuron fate commitment
GO:0042475 IEA:Ensembl P odontogenesis of dentin-containing tooth
GO:0014003 IEA:Ensembl P oligodendrocyte development
GO:0048645 IEA:Ensembl P organ formation
GO:0002076 IEA:Ensembl P osteoblast development
GO:0060021 IEA:Ensembl P palate development
GO:0031016 IEA:Ensembl P pancreas development
GO:0001569 IEA:Ensembl P patterning of blood vessels
GO:0009949 IEA:Ensembl P polarity specification of anterior/posterior axis
GO:0046638 IEA:Ensembl P positive regulation of alpha-beta T cell differentiation
GO:0051781 IEA:Ensembl P positive regulation of cell division
GO:0060769 IEA:Ensembl P positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0007228 IEA:Ensembl P positive regulation of hh target transcription factor activity
GO:0033092 IEA:Ensembl P positive regulation of immature T cell proliferation in thymus
GO:2000358 IEA:Ensembl P positive regulation of kidney smooth muscle cell differentiation
GO:2000729 IEA:Ensembl P positive regulation of mesenchymal cell proliferation involved in ureter development
GO:0002052 IEA:Ensembl P positive regulation of neuroblast proliferation
GO:0048714 IEA:Ensembl P positive regulation of oligodendrocyte differentiation
GO:0042307 IEA:Ensembl P positive regulation of protein import into nucleus
GO:0061189 IEA:Ensembl P positive regulation of sclerotome development
GO:0014858 IEA:Ensembl P positive regulation of skeletal muscle cell proliferation
GO:0048643 IEA:Ensembl P positive regulation of skeletal muscle tissue development
GO:0051155 IEA:Ensembl P positive regulation of striated muscle cell differentiation
GO:0033089 IEA:Ensembl P positive regulation of T cell differentiation in thymus
GO:0045944 IEA:Ensembl P positive regulation of transcription from RNA polymerase II promoter
GO:2000063 IEA:Ensembl P positive regulation of ureter smooth muscle cell differentiation
GO:0030177 IEA:Ensembl P positive regulation of Wnt signaling pathway
GO:0045059 IEA:Ensembl P positive thymic T cell selection
GO:0060516 IEA:Ensembl P primary prostatic bud elongation
GO:0060523 IEA:Ensembl P prostate epithelial cord elongation
GO:0034504 IEA:Ensembl P protein localization to nucleus
GO:0060782 IEA:Ensembl P regulation of mesenchymal cell proliferation involved in prostate gland development
GO:0042481 IEA:Ensembl P regulation of odontogenesis
GO:0060685 IEA:Ensembl P regulation of prostatic bud formation
GO:0060458 IEA:Ensembl P right lung development
GO:0060662 IEA:Ensembl P salivary gland cavitation
GO:0021938 IEA:Ensembl P smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0061053 IEA:Ensembl P somite development
GO:0021513 IEA:Ensembl P spinal cord dorsal/ventral patterning
GO:0021522 IEA:Ensembl P spinal cord motor neuron differentiation
GO:0014706 IEA:Ensembl P striated muscle tissue development
GO:0021978 IEA:Ensembl P telencephalon regionalization
GO:0021794 IEA:Ensembl P thalamus development
GO:0048538 IEA:Ensembl P thymus development
GO:0030878 IEA:Ensembl P thyroid gland development
GO:0060439 IEA:Ensembl P trachea morphogenesis
GO:0001570 IEA:Ensembl P vasculogenesis

KEGG Pathway Links

KEGG Pathway ID Description
ko05217 Basal cell carcinoma
mcc05217 Basal cell carcinoma
ko04340 Hedgehog signaling pathway
mcc04340 Hedgehog signaling pathway
mcc05200 Pathways in cancer

Domain Information

InterPro Annotations

Accession Description
IPR028992 Hedgehog/Intein (Hint) domain
IPR000320 Hedgehog, N-terminal signalling domain
IPR001657 Hedgehog protein
IPR001767 Hedgehog protein, Hint domain
IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain
IPR003586 Hint domain C-terminal
IPR003587 Hint domain N-terminal
IPR006141 Intein splice site

UniProt Annotations

Entry Information

Gene Name
sonic hedgehog
Protein Entry
F7E9N5_MACMU
UniProt ID
F7E9N5
Species
Rhesus monkey

Comments

Comment Type Description
Caution The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Function Intercellular signal essential for a variety of patterning events during development.
Similarity Belongs to the hedgehog family.

Identical and Related Proteins

Unique RefSeq proteins for LMP014826 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
297289745 RefSeq XP_001106515 465 sonic hedgehog

Identical Sequences to LMP014826 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP014826 proteins

Reference Database Accession Length Protein Name
GI:297289745 RefSeq XP_003280908.1 465 PREDICTED: LOW QUALITY PROTEIN: sonic hedgehog protein [Nomascus leucogenys]
GI:297289745 RefSeq XP_005551326.1 465 PREDICTED: sonic hedgehog protein [Macaca fascicularis]
GI:297289745 RefSeq XP_007981789.1 465 PREDICTED: sonic hedgehog protein [Chlorocebus sabaeus]
GI:297289745 RefSeq XP_010327869.1 465 PREDICTED: sonic hedgehog protein [Saimiri boliviensis boliviensis]