Gene/Proteome Database (LMPD)

LMPD ID
LMP014864
Gene ID
711248
Species
Macaca mulatta (Rhesus monkey)
Gene Name
sphingomyelin phosphodiesterase 1, acid lysosomal
Gene Symbol
SMPD1
Alternate Names
sphingomyelin phosphodiesterase 1, acid lysosomal;
Chromosome
14
Map Location
chromosome:14
EC Number
3.1.4.12

Proteins

Refseq ID XP_001110212
Protein GI 109107508
UniProt ID F7C9N4
mRNA ID XM_001110212
Length 629
MPRYGASPRQSRPRSGREQGQDRTFGAPRLLWMGLVLVLALALALALSDSLVLWAPAEAHPLPPQGHPARLHRIVPRLRDVFGWGNLTCPVCKGLFTAINLGLKKEPNVARVGSMAIKLCNLLKIAPPAVCQSIVQLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHDYLEGMDPDCADPLCCRQGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHIVLDHETYILNLTQANTPGAIPHWQLLYKARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMLDGSLPEAQSLWPRPLFC
Refseq ID XP_001110073
Protein GI 109107510
UniProt ID F7C9M3
mRNA ID XM_001110212
Length 585
MPRYGASPRQSRPRSGREQGQDRTFGAPRLLWMGLVLVLALALALALSDSLVLWAPAEAHPLPPQGHPARLHRIVPRLRDVFGWGNLTCPVCKGLFTAINLGLKKEPNVARVGSMAIKLCNLLKIAPPAVCQSIVQLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHDYLEGMDPDCADPLCCRQGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRYLSSMETQEGKKKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHIVLDHETYILNLTQANTPGAIPHWQLLYKARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMLDGSLPEAQSLWPRPLFC

Gene Information

Entrez Gene ID
711248
Gene Name
sphingomyelin phosphodiesterase 1, acid lysosomal
Gene Symbol
SMPD1
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0004767 IEA:UniProtKB-EC F sphingomyelin phosphodiesterase activity
GO:0046513 IEA:Ensembl P ceramide biosynthetic process
GO:0043407 IEA:Ensembl P negative regulation of MAP kinase activity
GO:0035307 IEA:Ensembl P positive regulation of protein dephosphorylation
GO:0006685 IEA:InterPro P sphingomyelin catabolic process
GO:0023021 IEA:Ensembl P termination of signal transduction

KEGG Pathway Links

KEGG Pathway ID Description
ko04142 Lysosome
mcc04142 Lysosome
mcc01100 Metabolic pathways
ko00600 Sphingolipid metabolism
mcc00600 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like
IPR008139 Saposin B
IPR011001 Saposin-like
IPR011160 Sphingomyelin phosphodiesterase

UniProt Annotations

Entry Information

Gene Name
sphingomyelin phosphodiesterase 1, acid lysosomal
Protein Entry
F7C9N4_MACMU
UniProt ID
F7C9N4
Species
Rhesus monkey

Comments

Comment Type Description
Catalytic Activity Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
Caution The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Function Converts sphingomyelin to ceramide.
Similarity Belongs to the acid sphingomyelinase family.

Identical and Related Proteins

Unique RefSeq proteins for LMP014864 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
109107508 RefSeq XP_001110212 629 sphingomyelin phosphodiesterase 1, acid lysosomal
109107510 RefSeq XP_001110073 585 sphingomyelin phosphodiesterase 1, acid lysosomal

Identical Sequences to LMP014864 proteins

Reference Database Accession Length Protein Name
GI:109107508 RefSeq XP_005578867.1 629 PREDICTED: sphingomyelin phosphodiesterase isoform X1 [Macaca fascicularis]

Related Sequences to LMP014864 proteins

Reference Database Accession Length Protein Name
GI:109107510 GenBank EAW68727.1 587 sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase), isoform CRA_b [Homo sapiens]
GI:109107510 GenBank ACP57216.1 587 Sequence 1345 from patent US 7482117
GI:109107510 GenBank ADS30813.1 587 Sequence 1345 from patent US 7781168
GI:109107510 GenBank AFH33700.1 629 sphingomyelin phosphodiesterase isoform 1 precursor [Macaca mulatta]