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Structure Database (LMSD)

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Common Name

Thapsic acid

Systematic Name

Hexadecanedioic acid

Synonyms

Thaspic acid

LM ID

LMFA01170022

Formula

C₁₆H₃₀O₄

Exact Mass

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286.214411

Sum Composition

FA 16:1;O2

Status

Curated

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Classification

Biological Context

Hexadecanedioic acid is a dicarboxylic fatty acid that has been found in the suberin component of silver birch (B. pendula) outer bark and soil.^1,2 It stimulates mitochondrial respiration and decreases the production of reactive oxygen species (ROS) induced by rotenone in isolated rat liver mitochondria when used at concentrations of 100 and 40 µM, respectively.³

This information has been provided by Cayman Chemical

References

1. Karnaouri, A., Lange, H., Crestini, C., et al. Chemoenzymatic fractionation and characterization of pretreated birch outer bark. ACS Sustainable Chem. Eng. 4(10), 5289-5302 (2016).

3. Sememova, A.A., V.N., S., Pavlova, S.I., et al. ω-Hydroxypalmitic and α,ω-hexadecanedioic acids as activators of free respiration and inhibitors of H2O2 generation in liver mitochondria. Biochem. Moscow Suppl. Ser. A 14(1), 24-33 (2020).

2. Hamer, U., Rumpel, C., and Dignac, M.-F. Cutin and suberin biomarkers as tracers for the turnover of shoot and root derived organic matter along a chronosequence of Ecuadorian pasture soils. Eur. J. Soil Sci. 63(6), 808-819 (2012).