LIPID MAPS

Structure Database (LMSD)

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Common Name

Maresin 2

Systematic Name

13R,14S-dihydroxy-4Z,7Z,9E,11E,16Z,19Z-docosahexaenoic acid

Synonyms

13R,14S-diHDHA
13,14-dihydroxydocosahexaenoic acid
Mar2

LM ID

LMFA04050004

Formula

C₂₂H₃₂O₄

Exact Mass

Calculate m/z

360.230061

Sum Composition

FA 22:6;O2

Status

Curated

Show lipids differing only in stereochemistry/bond geometry

View spectra on LIPID MAPS Standard Spectra DB

Classification

Biological Context

Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-lipoxygenase and soluble epoxide hydrolase co-incubated with DHA.¹ At 1 ng/mouse, MaR2 was shown to reduce neutrophil infiltration by 40% in a mouse model of peritonitis, and at 10 pM, MaR2 can enhance human macrophage phagocytosis of zymosan A by 90%.¹

This information has been provided by Cayman Chemical

References

1. Deng, B., Wang, C.W., Arnardottir, H.H., et al. Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages. PLoS One 9(7), (2014).

References

Taxonomy Information

Curated from

NCBI taxonomy class

Reference

Homo sapiens (#9606)

Mammalia (#40674)

Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator From Human Macrophages.,
PLoS One, 2014

Pubmed ID: 25036362

DOI: 10.1371/journal.pone.0102362

String Representations

InChiKey (Click to copy)

ALWYOLKNLLFCAY-GYROAIJESA-N

InChi (Click to copy)

InChI=1S/C22H32O4/c1-2-3-4-5-11-14-17-20(23)21(24)18-15-12-9-7-6-8-10-13-16-19-22(25)26/h3-4,6-7,9-15,18,20-21,23-24H,2,5,8,16-17,19H2,1H3,(H,25,26)/b4-3-,7-6-,12-9+,13-10-,14-11-,18-15+/t20-,21+/m0/s1

SMILES (Click to copy)

C(CC/C=C\C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\C/C=C\CC)(=O)O