LIPID MAPS

Common Name

Corylin

Systematic Name

3-(2,2-Dimethyl-2H-1-benzopyran-6-yl)-7-hydroxy-4H-1-benzopyran-4-one

Synonyms

LM ID

LMPK12050033

Formula

C₂₀H₁₆O₄

Exact Mass

Calculate m/z

320.10486

Status

Curated

Show lipids differing only in stereochemistry/bond geometry

View NP-MRD ID(NMR) spectrum

Category

Main Class

Sub Class

Polyketides [PK]

Flavonoids [PK12]

Isoflavonoids [PK1205]

Corylin is a flavonoid that has been found in P. corylifolia and has diverse biological activities.^{1,2,3,4,5,6,7,8} It inhibits carboxylesterase 1 (CES1; Ki = 0.7 µM), aldose reductase (IC50 = 7.5 µM), and IL-6-induced STAT3 activation in a reporter assay using Hep3B cells (IC50 = 1.37 µM).^1,9,3 Corylin (10 µM) inhibits the migration and invasion of MCF-7 and MDA-MB-231 breast cancer cells and LPS-induced prostaglandin E2 (PGE2; Item No. 14010) and nitric oxide (NO) production in RAW 264.7 cells.^4,5 It induces osteogenesis in micromass cultures from rat E13 limb bud cells.⁶ Corylin decreases body weight and white adipose tissue weight and induces adipocyte browning in a mouse model of diet-induced obesity and increases survival in aged mice fed a high-fat diet.^7,8

This information has been provided by Cayman Chemical

References

1. Sun, D.X., Ge, G.B., Dong, P.P., et al. Inhibition behavior of fructus psoraleae’s ingredients towards human carboxylesterase 1 (hCES1). Xenobiotica 46(6), 503-510 (2016).

2. Shim, S.H., Kim, Y., Lee, J.Y., et al. Aldose reductase inhibitory activity of the compounds from the seed of Psoralea corylifolia. J. Korean Soc. Appl. Biol. Chem. 52(5), 568–572 (2009).

3. Lee, S.W., Yun, B.R., Kim, M.H., et al. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta Med. 78(9), 903-906 (2012).

4. Liu, S., Wang, L., and Zhang, R. Corylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target. Libyan J. Med. 16(1), 1883224 (2021).

5. Hung, Y.L., Fang, S.H., Wang, S.C., et al. Corylin protects LPS-induced sepsis and attenuates LPS-induced inflammatory response. Sci. Rep. 7, 46299 (2017).

6. Yu, A.X., Xu, M.L., Yao, P., et al. Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β-catenin signaling pathways. The FASEB Journal 34(3), 4311-4328 (2020).

7. Chen, C.C., Kuo, C.H., Leu, Y.L., et al. Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation. Pharmacol. Res. 164, 105291 (78370).

8. Wang, T.H., Tseng, W.C., Leu, Y.L., et al. The flavonoid corylin exhibits lifespan extension properties in mouse. Nat. Commun. 13(1), 1238 (2022).