Structure Database (LMSD)

Common Name
Tricin
Systematic Name
5,7,4'-Trihydroxy-3',5'-dimethoxyflavone
Synonyms
LM ID
LMPK12110873
Formula
Exact Mass
Calculate m/z
330.073955
Status
Curated



Classification

Biological Context

Tricin is a flavone that has been found in O. sativa and has diverse biological activities.1,2,3,4 It scavenges ABTS radicals in a cell-free assay (IC50 = 0.312 mg/ml).1 Tricin (0.1-10 µM) reduces virus titer and expression of the human cytomegalovirus (HCMV) genes IE1 and UL54 in HCMV-infected human embryonic lung fibroblast (HEL) cells, an effect that can be reversed by overexpression of chemokine (C-C motif) ligand 2 (CCL2).2 It inhibits IgE-induced degranulation of RBL-2H3 cells (IC50 = 4.83 µM).3 In vivo, tricin (37.5 mg/kg per day) reduces tumor growth and the number of lung metastases in a CT26 murine colon carcinoma model.4

This information has been provided by Cayman Chemical

References

1. Akai, Y., Sadanari, H., Takemoto, M., et al. Inhibition of human cytomegalovirus replication by tricin is associated with depressed CCL2 expression. Antiviral Res. 148, 15-19 (2017).

References

Taxonomy Information

Curated from
NCBI taxonomy class
Reference
Viridiplantae (#33090)
Flavonoid imported from http://metabolomics.jp/

String Representations

InChiKey (Click to copy)
HRGUSFBJBOKSML-UHFFFAOYSA-N
InChi (Click to copy)
InChI=1S/C17H14O7/c1-22-14-3-8(4-15(23-2)17(14)21)12-7-11(20)16-10(19)5-9(18)6-13(16)24-12/h3-7,18-19,21H,1-2H3
SMILES (Click to copy)
C12C(=O)C=C(C3C=C(OC)C(O)=C(OC)C=3)OC=1C=C(O)C=C2O

Other Databases

Wikipedia
KEGG ID
HMDB ID
CHEBI ID
METABOLOMICS ID
PubChem CID
Cayman ID

Calculated Physicochemical Properties

Heavy Atoms 24
Rings 3
Aromatic Rings 3
Rotatable Bonds 3
Van der Waals Molecular Volume 273.29
Topological Polar Surface Area 109.36
Hydrogen Bond Donors 3
Hydrogen Bond Acceptors 7
logP 3.49
Molar Refractivity 86.13

Admin

Created at
-
Updated at
-