N-Modified phospholipids (N-mod PL)
Class abbreviations
| Common Name | Abbreviation |
|---|---|
| N-modified phospholipids | |
| N-Alkyl PS | PS-N[Alk] |
| N-Acyl PS | PS-N[FA] |
| Phosphatidylserine-carboxyalkylpyrroles | PS-CAP |
| Phosphatidylserine-malondialdehydes | PS-MDE |
| N-Alkyl PE | PE-N[Alk] |
| N-Acyl PE | PE-N[FA] |
| Phosphatidylethanolamine-carboxyalkylpyrroles | PE-CAP |
| Phosphatidylethanolamine-glucosides | PE-Glu |
| Phosphatidylethanolamine-glucuronides | PE-GluA |
| Phosphatidylethanolamine-α-ketoglucoside | PE-GluK |
| Phosphatidylethanolamine-carboxymethylates | PE-CM |
| Phosphatidylethanolamine-carboxyethylates | PE-CE |
| Phosphatidylethanolamine-formamides | PE-FA |
| Phosphatidylethanolamine-carbamides | PE-CA |
| Phosphatidyethanolamine- malondialdehydes | PE-MDE |
| Phosphatidylethanolamine-hydroxynonenals | PE-HNE |
| Phosphatidylethanolamine-isolevuglandins | PE-isoLG |
Specific rule for N-modified PL and LPL species
In these subclasses the amino function in PS and PE species is modified by various electrophiles shown in the table for abbreviations. These functional groups are part of the subclass abbreviation, placed in a pair of brackets when modification is structurally detailed.
Hierarchical shorthand notation for examples of N-modified phospholipids
Species level: Sum composition, Molecular species level: Lipid species with identified acyl/alkyl-residues, sn-Position level: Fatty acyl/alkyl constituents at glycerol backbone are indicated by a slash, Full structure level: Molecular species with constituents and functional groups including positions.
| Oxidative modification | Species level1 | Molecular species level | sn-Position level | Full structure level |
|---|---|---|---|---|
| N-Alkyl | PS-N[Alk] 40:3 | PS-N[6:0] 16:0_18:3 | PS-N[6:0] 16:0/18:3 | PS-N[6:0] 16:0/18:3(9Z,12Z,15Z) |
| N-Acyl | PE-N[FA] 54:5 | PE-N[FA 18:1] 16:0_20:4 | PE-N[FA 18:1] 16:0/20:4 |
PE-N[FA 18:1(9Z)] 16:0/20:4(4Z,8Z,11Z,14Z)
|
| Hydroxynonenal adduct | PE-HNE 36:4 | PE-HNE 16:0_20:4 | PE-HNE 16:0/20:4 | PE-HNE 16:0/20:4(4Z,8Z,11Z,14Z) |
1 Annotation based on exact mass measurements using a high-resolution mass spectrometer, which allows differentiation of isobaric acyl and alkyl species.