Cellular lipid homeostasis: From lipid droplets to ferroptosis
Presented by:
Dr. James Olzmann
Synopsis
During this presentation you will:
• Understand how lipid droplets regulate cellular lipid balance and influence susceptibility to ferroptosis.
• Learn how FSP1 and other lipid-protective mechanisms suppress lipid peroxidation and cell death.
• Explore how targeting lipid metabolism and ferroptosis offers new therapeutic strategies for cancer.
• Discover how genetic screens reveal key regulators and mechanisms, uncovering novel therapeutic targets that control lipid homeostasis and ferroptotic vulnerability.
• Understand how lipid droplets regulate cellular lipid balance and influence susceptibility to ferroptosis.
• Learn how FSP1 and other lipid-protective mechanisms suppress lipid peroxidation and cell death.
• Explore how targeting lipid metabolism and ferroptosis offers new therapeutic strategies for cancer.
• Discover how genetic screens reveal key regulators and mechanisms, uncovering novel therapeutic targets that control lipid homeostasis and ferroptotic vulnerability.
About Dr. James Olzmann
Dr. James Olzmann is the Doris H. Calloway Chair and Professor of Molecular Therapeutics at the University of California, Berkeley, with joint appointments in the Departments of Molecular & Cell Biology and Nutritional Sciences & Toxicology. He received his B.S. from the University of Michigan, Ph.D. from Emory University, and conducted postdoctoral research with Dr. Ron Kopito at Stanford University before joining UC Berkeley in 2013. Dr. Olzmann’s laboratory investigates the mechanisms that regulate cellular lipid homeostasis, focusing on lipid droplets and ferroptosis. His group seeks to uncover how cells maintain lipid balance and to identify new therapeutic strategies targeting lipid metabolism and oxidative cell death. His contributions have been recognized with honors including the Presidential Early Career Award for Scientists and Engineers, the ASCB Günter Blobel Early Career Award, the ASBMB Avanti Lipids Award, and appointments as a Chan Zuckerberg Biohub Investigator and Miller Institute Professor.
Dr. James Olzmann