Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing

Presented by: Prof. Guillaume Thibault

Synopsis

Participants will gain an understanding of how Enterococcus faecalis disrupts wound healing by generating reactive oxygen species through extracellular electron transport (EET), leading to hyperactivation of the unfolded protein response (UPR), lipid peroxidation, and impaired epithelial cell migration. They will also learn how modulating ROS levels, such as through catalase treatment, can restore physiological UPR activity and cell migration, highlighting potential therapeutic strategies targeting bacterial redox metabolism in chronic infections.

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About Prof. Guillaume Thibault

Guillaume Thibault is an Associate Professor (tenured) at the School of Biological Sciences, Nanyang Technological University (NTU), where he also serves as Associate Dean (Graduate Studies) at the College of Science and Senator on the 10th NTU Senate. A biochemist and cell biologist by training, he earned his Ph.D. from the University of Toronto and completed postdoctoral work at Temasek Life Sciences Laboratory before establishing his independent research program at NTU, supported by the Elite Nanyang Assistant Professorship Award. His research investigates the interplay between lipid homeostasis and the unfolded protein response, with translational relevance to aging, metabolic disease, and wound infection. Beyond NTU, he is the founding President of the Society for Cell Biology Singapore, an Associate Editor for Molecular Biology of the Cell and Cell Biology International, Lead Organizer of the 2025 FASEB Endoplasmic Reticulum conference, and serves on multiple committees of the American Society for Cell Biology.
April 28th, 2026
5pm BST | 9am PDT | 12pm EDT
Image of Prof. Guillaume Thibault Prof. Guillaume Thibault Nanyang Technological University