Structure Database (LMSD)
Common Name
6-amino-hexanoic acid
Systematic Name
6-amino-hexanoic acid
Synonyms
- 6-Aminohexanoic acid
3D model of 6-amino-hexanoic acid
Please note: Where there are chiral atoms but the stereochemistry is undefined, the 3D model takes an arbitrary conformation
Classification
Category
Main Class
Sub Class
Biological Context
6-Aminocaproic acid is an inhibitor of the plasmin activating enzymes streptokinase, fibrinokinase, and urokinase (IC50s = ~8 μM for all in an enzyme assay).1 It is selective for plasmin activating enzymes over trypsin (IC50 = >500 μM). 6-Aminocaproic acid inhibits in vitro plasmin activation and fibrinolysis in a dose-dependent manner. Ex vivo, 6-aminocaproic acid reduces fibrinolysis in dog plasma following i.p. administration at doses ranging from 20-100 mg/kg.2 Formulations containing 6-aminocaproic acid have been used to decrease postoperative blood transfusion rates following knee surgery.3
This information has been provided by Cayman Chemical
References
2. Brown, J.C., Brainard, B.M., Fletcher, D.J., et al. Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis. Am. J. Vet. Res. 77(11), 1258-1265 (2016).
3. Alkjaersig, N., Fletcher, A.P., and Sherry, S. ɛ-Aminocaproic acid: An inhibitor of plasminogen activation. J. Biol. Chem. 234(4), 832-837 (1959).
String Representations
InChiKey (Click to copy)
SLXKOJJOQWFEFD-UHFFFAOYSA-N
InChi (Click to copy)
InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
SMILES (Click to copy)
C(CCCN)CC(=O)O
Other Databases
Calculated Physicochemical Properties
Heavy Atoms
9
Rings
0
Aromatic Rings
0
Rotatable Bonds
5
Van der Waals Molecular Volume
138.30
Topological Polar Surface Area
63.32
Hydrogen Bond Donors
2
Hydrogen Bond Acceptors
2
logP
0.87
Molar Refractivity
35.65
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Updated at
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