LIPID MAPS

Undecanedioic acid is a medium-chain dicarboxylic acid that has been found in S. officinalis.^1,2 It is active against T. rubrum, T. mentagrophytes, and M. canis when used at a concentration of 1 mM.² Undecanedioic acid has been used in the synthesis of proteolysis-targeting chimeras (PROTACs) with anticancer activity in mutant EGFR-expressing cancer cells.³ It has been found in urban and industrial aerosols of fine particulate matter less than 2.5 µm (PM2.5).⁴

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References

1. Crenn, V., Fronval, I., Petitprez, D., et al. Fine particles sampled at an urban background site and an industrialized coastal site in Northern France - Part 1: Seasonal variations and chemical characterization. Sci. Total Environ. 578, 203-218 (2017).

2. Aldal'In, H.K., Wedian, F., Al-Mazaideh, G.M., et al. Comparative analysis of phytochemical composition of ethanolic extract of Jordanian Silvia officinalis. Pak. J. Biol. Sci. 23(8), 989-994 (2022).

3. Brasch, J., and Friege, B. Dicarboxylic acids affect the growth of dermatophytes in vitro. Acta Derm. Venereol. 74(5), 347-350 (1994).

4. Li, Q., Guo, Q., Wang, S., et al. Design and synthesis of proteolysis targeting chimeras (PROTACs) as an EGFR degrader based on CO-1686. Eur. J. Med. Chem. 238, 114455 (2022).