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Structure Database (LMSD)

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Common Name

Kaempferide

Systematic Name

Synonyms

LM ID

LMPK12110563

Formula

C₁₆H₁₂O₆

Exact Mass

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300.06339

Status

Curated

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Classification

Biological Context

Kaempferide is a flavonoid that has been found in Alpinia and has diverse biological activities.^1,2,3,4 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals in a cell-free assay (IC50 = 97.58 μg/ml).¹ Kaempferide is cytotoxic to HT-1080 and Colon 26-L5 cells (EC50s = 2.91 and 5.95 μg/ml, respectively) and decreases lipid accumulation in 3T3-L1 preadipocytes when used at a concentration of 50 μM.^2,3 It attenuates decreases in left ventricular systolic pressure (LVSP) and increases in left ventricular end-diastolic pressure (LVEDP) and reduces infarct size in a rat model of myocardial ischemia-reperfusion injury induced by coronary artery ligation when administered at doses of 0.3 and 1 mg/kg.⁴

This information has been provided by Cayman Chemical

References

1. Bian, Q.-Y., Wang, S.-Y., Xu, L.-J., et al. Two new antioxidant diarylheptanoids from the fruits of Alpinia oxyphylla. J. Asian Nat. Prod. Res. 15(10), 1094-1099 (2013).

2. Banskota, A.H., Tezuka, Y., Prasain, J.K., et al. Chemical constituents of brazilian propolis and their cytotoxic activities. J. Nat. Prod. 61(7), 896-900 (1998).

3. Kumkarnjana, S., Suttisri, R., Nimmannit, U., et al. Anti-adipogenic effect of flavonoids from Chromolaena odorata leaves in 3T3-L1 adipocytes. J. Integr. Med. 16(6), 427-434 (2018).

4. Wang, D., Zhang, X., Li, D., et al. Kaempferide protects against myocardial ischemia/reperfusion injury through activation of the PI3K/Akt/GSK-3 β pathway. Mediators Inflamm. 5278218, (2017).