Salvigenin is a polyphenol flavonoid originally found in Alnus japonica with diverse biological activities.^1,2,3 It inhibits hydrogen peroxide-induced apoptosis and reduces the generation of reactive oxygen species (ROS) in SH-SY5Y human neuroblastoma cells when used at a concentration of 25 µM.² Salvigenin (25 and 50 µM) decreases cleaved caspase-3 levels and the Bax/B cell lymphoma 2 (Bcl-2) ratio in SH-SY5Y cells. It reduces the viability of MCF-7 human breast cancer cells in a concentration-dependent manner.³ Salvigenin (3.65-9.68 µg/mouse per day) enhances the delayed-type hypersensitivity (DTH) response to sheep red blood cells in mice. It increases the production of IFN-γ induced by lysate antigens in isolated mouse splenocytes. Salvigenin (9.68 µg/mouse per day) reduces tumor growth in a spontaneous mouse mammary tumor (SMMT) model.