α-Tocotrienol is an antioxidant and a form of vitamin E that has been found in rice bran and has neuroprotective properties.^1,2,3,4 It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 , or L-buthionine-(S,R)-sulfoximine (BSO) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.² Cytosolic microinjection of α-tocotrienol prevents glutamate-induced cell death and phosphorylation of 12-lipoxygenase (12-LO) in HT4 neurons.³ It reduces glutamate-induced cytosolic and mitochondrial production of reactive oxygen species (ROS), accumulation of N-terminally truncated Bcl-xL (ΔN-Bcl-xL), and cell death in primary rat hippocampal neurons.⁴ α-Tocotrienol (50 mg/kg) reduces infarct size in a spontaneously hypertensive rat model of stroke induced by tandem right common carotid artery and middle cerebral artery occlusion.³ [Matreya, LLC. Catalog No. 2109]