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Structure Database (LMSD)

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Common Name

Aldosterone

Systematic Name

11β,21-dihydroxy-3,20-dioxo-pregn-4-ene-18-al

Synonyms

11beta,21-dihydroxy-3,20-diketo-4-pregnen-18-al

LM ID

LMST02030026

Formula

C₂₁H₂₈O₅

Exact Mass

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360.193675

Sum Composition

ST 21:4;O5

Status

Curated

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Classification

Biological Context

Aldosterone is a steroid hormone secreted by the adrenal cortex and is the principle mineralocorticoid controlling sodium and potassium balance.^1,2 Its primary role is to promote unidirectional salt reabsorption in epithelial tissues. Aldosterone is synthesized from cholesterol in the zona glomerulosa of the adrenal cortex and its secretion is regulated via the renin-angiotensin system.³

This information has been provided by Cayman Chemical

References

1. Rogerson, F.M., and Fuller, P.J. Mineralocorticoid action. Steroids 65, 61-73 (2000).

2. Agarwal, M.K., and Mirshahi, M. General overview of mineralocorticoid hormone action. Pharmacol. Toxicol. 84, 273-326 (1999).

3. Lumbers, E.R. Angiotensin and aldosterone. Regul. Pept. 80, 91-100 (1999).

Reactions

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References

Taxonomy Information

Curated from

NCBI taxonomy class

Reference

Bos taurus (#9913)

Mammalia (#40674)

[Constitution of aldosterone, a new mineralocorticoid].,
Experientia, 1954

Pubmed ID: 13161890

String Representations

InChiKey (Click to copy)

PQSUYGKTWSAVDQ-ZVIOFETBSA-N

InChi (Click to copy)

InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

SMILES (Click to copy)

[C@]12(CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@]1(C=O)[C@@H](C(=O)CO)CC[C@@]21[H])[H]