Structure Database (LMSD)
Common Name
PC(7:0/7:0)
Systematic Name
1,2-diheptanoyl-sn-glycero-3-phosphocholine
Synonyms
- alpha-L-Diheptanoylphosphatidylcholine
- 1,2-Diheptanoyl-sn-glycerol-3-phosphorylcholine
- Diheptanoyllecithin
- L-alpha-Diheptanoyllecithin
- L-alpha-Diheptanoylphosphatidylcholine
- L-Diheptanoylphosphatidylcholine
- PC(14:0)
- PC(7:0/7:0)
LM ID
LMGP01011238
Formula
Exact Mass
Calculate m/z
481.280457
Sum Composition
Abbrev Chains
PC 7:0_7:0
Status
Curated
3D model of PC(7:0/7:0)
Please note: Where there are chiral atoms but the stereochemistry is undefined, the 3D model takes an arbitrary conformation
Classification
Category
Main Class
Sub Class
Biological Context
1,2-Diheptanoyl-sn-glycero-3-PC (DHPC-C7) is a synthetic phosphatidylcholine containing the short-chain (7:0) heptanoic acid at the sn-1 and sn-2 positions. It is commonly used in the formation of lipid bilayers and mixed micelles that has a critical micelle concentration (CMC) of 1.6 mM.1,2 Short-chain phospholipids, such as DHPC-C7 and 1,2-dihexanoyl-sn-glycero-PC (DHPC-C6), increase the formation rate of substrate-supported planar phospholipid bilayers on glass and silica.2 DHPC-C7 inhibits insulin fibril formation in vitro in a concentration-dependent manner and inhibits cytotoxicity induced by insulin fibril formation in PC12 and SH-SY5Y cells when used at concentrations ranging from 0.5 to 4 mM.3
This information has been provided by Cayman Chemical
References
1. Faustino, C.M.C., Calado, A.R.T., and Garcia-Rio, L. Mixed micelle formation between amino acid-based surfactants and phospholipids. J. Colloid. Interface Sci. 359(2), 493-498 (2011).
3. Wang, S.S.-S., Liu, K.-N., and Han, T.-C. Amyloid fibrillation and cytotoxicity of insulin are inhibited by the amphiphilic surfactants. Biochim. Biophys. Acta 1802(6), 519-530 (2010).
Reactions
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Reactions are shown if the E.C. number of the enzyme catalysing it is annotated in the UniProt database for a species belonging to the selected taxonomic class.
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String Representations
InChiKey (Click to copy)
RBFSPQDASPEAID-HXUWFJFHSA-N
InChi (Click to copy)
InChI=1S/C22H44NO8P/c1-6-8-10-12-14-21(24)28-18-20(31-22(25)15-13-11-9-7-2)19-30-32(26,27)29-17-16-23(3,4)5/h20H,6-19H2,1-5H3/t20-/m1/s1
SMILES (Click to copy)
[C@](COP(=O)([O-])OCC[N+](C)(C)C)([H])(OC(CCCCCC)=O)COC(CCCCCC)=O
Other Databases
Calculated Physicochemical Properties
Heavy Atoms
32
Rings
0
Aromatic Rings
0
Rotatable Bonds
22
Van der Waals Molecular Volume
485.03
Topological Polar Surface Area
111.19
Hydrogen Bond Donors
0
Hydrogen Bond Acceptors
9
logP
5.02
Molar Refractivity
123.24
Admin
Created at
-
Updated at
14th Mar 2025
LIPID MAPS® abbreviations for glycerophospholipids (GP)
The LIPID MAPS® glycerophospholipid abbreviations (PC, PE, etc.) are used here to refer to species with one or two radyl side-chains where the structures of the side chains are indicated within parentheses in the 'Headgroup(sn1/sn2)' format (e.g. PC(16:0/18:1(9Z)). By default, R stereochemistry at the C-2 carbon of glycerol and attachment of the headgroup at the sn3 position is assumed. Also, acyl chains are assumed by default. The 'O-' prefix is used to indicate the presence of an alkyl ether substituent e.g. PC(O-16:0/18:1(9Z)), whereas the 'P-' prefix is used for the 1Z-alkenyl ether (Plasmalogen) substituent e.g. PC(P-16:0/18:1(9Z)).
For molecules with opposite (S) stereochemistry at C2 of the glycerol group and attachment of the headgroup at the sn1 position, the stereochemistry specification of [S] is appended to the abbreviation. The 'Headgroup(sn3/sn2)' abbreviation format is used.
For molecules with unknown stereochemistry at the C-2 carbon of the glycerol group, the stereochemistry specification of [U] is appended to the abbreviation and the structure is drawn with C-2 stereochemistry unspecified.
The LIPID MAPS® glycerophospholipid abbreviations (PC, PE, etc.) are used here to refer to species with one or two radyl side-chains where the structures of the side chains are indicated within parentheses in the 'Headgroup(sn1/sn2)' format (e.g. PC(16:0/18:1(9Z)). By default, R stereochemistry at the C-2 carbon of glycerol and attachment of the headgroup at the sn3 position is assumed. Also, acyl chains are assumed by default. The 'O-' prefix is used to indicate the presence of an alkyl ether substituent e.g. PC(O-16:0/18:1(9Z)), whereas the 'P-' prefix is used for the 1Z-alkenyl ether (Plasmalogen) substituent e.g. PC(P-16:0/18:1(9Z)).
For molecules with opposite (S) stereochemistry at C2 of the glycerol group and attachment of the headgroup at the sn1 position, the stereochemistry specification of [S] is appended to the abbreviation. The 'Headgroup(sn3/sn2)' abbreviation format is used.
For molecules with unknown stereochemistry at the C-2 carbon of the glycerol group, the stereochemistry specification of [U] is appended to the abbreviation and the structure is drawn with C-2 stereochemistry unspecified.