Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

Search by fold change ratio | Search by KEGG pathway | Search by LIPID MAPS lipid pathway

Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Pyrimidine metabolism (mmu00240)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2410015N
17Rik
KLA  ATP  ATP+KLA
 NM_023203 RIKEN cDNA 2410015N17 gene (2410015N17Rik), mRNA [NM_023203] KLA .70 .71 .68 .57 .49 .39 .52
ATP .98 1.00 1.30 1.28 1.02 .65 .49
KLA/ATP .69 .71 .86 .84 .70 .52 .39
AK047274
KLA  ATP  ATP+KLA
 AK047274 10 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:B930044L01 product:unclassifiable, full insert sequence. [AK047274] KLA .92 .85 .90 .92 .98 .93 .92
ATP 1.03 1.11 1.07 .90 .89 .93 .94
KLA/ATP .89 .96 .94 .84 .93 .92 .92
Ak3
KLA  ATP  ATP+KLA
 NM_021299 adenylate kinase 3 (Ak3), mRNA [NM_021299] KLA .89 .87 .90 .77 .76 .60 .63
ATP 1.18 1.21 .90 1.15 .84 .49 .53
KLA/ATP 1.01 1.04 .67 .79 .58 .48 .46
BU938682
KLA  ATP  ATP+KLA
 BU938682 gb|AGENCOURT_10517489 NIH_MGC_169 Mus musculus cDNA clone IMAGE:6706854 5, mRNA sequence [BU938682] KLA 1.02 .94 .94 .92 .92 .98 .98
ATP .98 1.01 .95 .88 .87 .87 1.02
KLA/ATP .90 .96 .96 .95 .90 .86 .93
Cad
KLA  ATP  ATP+KLA
 NM_023525 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (Cad), mRNA [NM_023525] KLA .88 .82 .73 .65 .53 .46 .59
ATP 1.00 1.00 .94 .86 .74 .60 .67
KLA/ATP .86 .81 .76 .65 .55 .46 .44
Cant1
KLA  ATP  ATP+KLA
 NM_029502 calcium activated nucleotidase 1 (Cant1), transcript variant 1, mRNA [NM_029502] KLA 1.11 1.12 1.26 1.22 1.42 1.72 1.45
ATP 1.08 1.14 1.00 1.15 .90 1.29 1.86
KLA/ATP 1.16 1.19 .95 1.10 .91 1.42 2.79
Cda
KLA  ATP  ATP+KLA
 NM_028176 cytidine deaminase (Cda), mRNA [NM_028176] KLA .92 .97 .89 .86 .87 .85 .88
ATP 1.08 1.11 1.00 1.40 1.40 1.04 1.09
KLA/ATP .98 .95 .90 .96 .88 .93 .97
Cmpk1
KLA  ATP  ATP+KLA
 NM_025647 cytidine monophosphate (UMP-CMP) kinase 1 (Cmpk1), mRNA [NM_025647] KLA 1.32 1.31 1.32 1.37 1.15 1.07 1.22
ATP 1.12 1.11 1.24 1.48 1.19 1.05 1.40
KLA/ATP 1.32 1.50 1.51 1.61 1.38 1.22 1.69
Cmpk2
KLA  ATP  ATP+KLA
 NM_020557 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial (Cmpk2), nuclear gene encoding mitochondrial protein, mRNA [NM_020557] KLA 45.62 35.73 40.02 38.05 26.87 32.74 16.83
ATP 1.12 1.13 1.07 1.09 1.70 19.99 11.48
KLA/ATP 40.89 44.06 53.14 44.67 39.01 36.20 40.60
Ctps
KLA  ATP  ATP+KLA
 NM_016748 cytidine 5-triphosphate synthase (Ctps), mRNA [NM_016748] KLA .47 .41 .26 .18 .14 .21 .37
ATP .87 .80 1.08 .67 .73 .63 .33
KLA/ATP .40 .39 .41 .28 .27 .38 .13
Ctps2
KLA  ATP  ATP+KLA
 NM_018737 cytidine 5-triphosphate synthase 2 (Ctps2), mRNA [NM_018737] KLA .76 .77 .71 .73 .67 .75 1.09
ATP .98 .93 .99 .86 .76 .64 .81
KLA/ATP .77 .74 .71 .63 .62 .60 .86
Dck
KLA  ATP  ATP+KLA
 NM_007832 deoxycytidine kinase (Dck), mRNA [NM_007832] KLA 2.69 2.67 3.17 3.00 3.16 3.18 2.10
ATP 1.15 1.32 1.25 1.48 1.19 3.17 1.47
KLA/ATP 2.71 2.88 2.59 4.36 3.64 4.49 3.08
Dctd
KLA  ATP  ATP+KLA
 NM_178788 dCMP deaminase (Dctd), mRNA [NM_178788] KLA .70 .66 .64 .65 .59 .62 .71
ATP 1.02 1.10 .86 .84 .63 .60 .62
KLA/ATP .72 .68 .66 .62 .63 .59 .65
Dhodh
KLA  ATP  ATP+KLA
 NM_020046 dihydroorotate dehydrogenase (Dhodh), nuclear gene encoding mitochondrial protein, mRNA [NM_020046] KLA .75 .68 .63 .77 .65 .59 .86
ATP 1.10 1.01 1.16 1.14 .95 .53 .71
KLA/ATP .70 .74 .85 .83 .64 .54 .42
Dpyd
KLA  ATP  ATP+KLA
 NM_170778 dihydropyrimidine dehydrogenase (Dpyd), mRNA [NM_170778] KLA .94 .95 1.00 .98 .99 .98 .97
ATP 1.04 .95 1.02 1.01 1.02 1.02 .98
KLA/ATP 1.03 .98 .98 1.02 1.02 1.05 .93
Dtymk
KLA  ATP  ATP+KLA
 NM_001105667 deoxythymidylate kinase (Dtymk), transcript variant 1, mRNA [NM_001105667] KLA .62 .62 .59 .51 .46 .53 .50
ATP 1.02 .99 1.24 1.08 .67 .33 .36
KLA/ATP .60 .58 .73 .64 .47 .31 .26
Dtymk
KLA  ATP  ATP+KLA
 NM_023136 deoxythymidylate kinase (Dtymk), transcript variant 2, mRNA [NM_023136] KLA .69 .65 .55 .62 .39 .37 .38
ATP .90 .88 1.44 1.32 .99 .48 .33
KLA/ATP .57 .63 .88 .81 .67 .35 .14
Dut
KLA  ATP  ATP+KLA
 NM_023595 deoxyuridine triphosphatase (Dut), nuclear gene encoding mitochondrial protein, mRNA [NM_023595] KLA .50 .47 .37 .34 .18 .14 .16
ATP 1.01 .97 1.27 1.27 .94 .23 .17
KLA/ATP .47 .48 .62 .52 .41 .22 .12
Entpd1
KLA  ATP  ATP+KLA
 NM_009848 ectonucleoside triphosphate diphosphohydrolase 1 (Entpd1), mRNA [NM_009848] KLA .75 .72 .77 .64 .57 .42 .24
ATP 1.21 1.24 1.23 1.59 1.14 .70 1.33
KLA/ATP .87 .91 .78 1.03 .64 .66 1.14
Entpd3
KLA  ATP  ATP+KLA
 NM_178676 ectonucleoside triphosphate diphosphohydrolase 3 (Entpd3), mRNA [NM_178676] KLA .98 1.01 .99 .97 1.05 1.00 .99
ATP 1.02 1.02 .99 1.07 1.02 .99 1.28
KLA/ATP 1.00 1.03 1.00 1.06 1.07 1.11 1.27
Entpd4
KLA  ATP  ATP+KLA
 NM_026174 ectonucleoside triphosphate diphosphohydrolase 4 (Entpd4), mRNA [NM_026174] KLA .89 .83 .82 .74 .67 .78 .92
ATP .97 1.05 .92 .87 .71 .69 .92
KLA/ATP .86 .83 .73 .73 .61 .73 .78
Entpd5
KLA  ATP  ATP+KLA
 NM_001026214 ectonucleoside triphosphate diphosphohydrolase 5 (Entpd5), transcript variant 2, mRNA [NM_001026214] KLA .93 .98 .90 .82 .69 .55 .55
ATP .94 .99 1.15 1.08 .99 1.02 2.14
KLA/ATP .90 .97 1.04 .91 .79 .71 1.38
Entpd6
KLA  ATP  ATP+KLA
 AK030789 adult male thymus cDNA, RIKEN full-length enriched library, clone:5830401O07 product:ectonucleoside triphosphate diphosphohydrolase 6, full insert sequence [AK030789] KLA .79 .81 .65 .72 .78 .79 .90
ATP 1.11 .98 .66 .69 .74 .72 .84
KLA/ATP .81 .74 .65 .68 .79 .67 .67
Entpd6
KLA  ATP  ATP+KLA
 NM_172117 ectonucleoside triphosphate diphosphohydrolase 6 (Entpd6), mRNA [NM_172117] KLA .84 .79 .70 .68 .73 .88 1.18
ATP 1.07 1.19 .69 .70 .48 .57 1.21
KLA/ATP .83 .81 .57 .63 .48 .68 .80
Entpd8
KLA  ATP  ATP+KLA
 NM_028093 ectonucleoside triphosphate diphosphohydrolase 8 (Entpd8), mRNA [NM_028093] KLA 1.05 .98 1.07 .98 .96 .99 1.01
ATP 1.05 1.01 .91 1.04 1.07 1.01 .90
KLA/ATP .97 1.07 1.04 1.01 .99 1.07 .99
Itpa
KLA  ATP  ATP+KLA
 NM_025922 inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), mRNA [NM_025922] KLA 1.02 .96 1.01 1.18 1.37 1.83 1.44
ATP .96 .93 1.08 .95 .92 1.66 1.38
KLA/ATP .86 .94 1.20 1.08 1.28 2.15 2.45
Mm.13558
1
KLA  ATP  ATP+KLA
 34328145 Unknown KLA .73 .64 .50 .54 .38 .49 1.02
ATP .88 .84 1.16 .94 .66 .72 .68
KLA/ATP .56 .62 .71 .49 .40 .30 .42
Mm.17932
KLA  ATP  ATP+KLA
 142368657 Unknown KLA 1.96 2.16 2.26 2.04 1.94 2.22 1.33
ATP 1.19 1.29 2.96 4.36 1.42 1.27 1.16
KLA/ATP 4.95 7.89 18.00 12.21 3.38 1.85 1.27
Mm.21511
5
KLA  ATP  ATP+KLA
 146149315 Unknown KLA .94 .93 .96 .95 .89 .95 1.08
ATP 1.02 .93 1.00 .83 .78 .92 1.58
KLA/ATP .90 .96 .93 .85 .77 .83 .83
Mm.3458
KLA  ATP  ATP+KLA
 119226250 Unknown KLA .85 .78 .75 .84 .74 .81 .79
ATP .97 .83 1.09 .93 2.03 1.96 .89
KLA/ATP .81 .72 .89 .63 1.72 1.77 .79
Mm.43970
2
KLA  ATP  ATP+KLA
 38327645 Unknown KLA .89 .90 .82 .83 .70 .65 .67
ATP 1.00 .95 1.37 1.24 1.13 .76 .97
KLA/ATP .87 .88 1.23 .98 1.02 .64 .36
Mm.4610
KLA  ATP  ATP+KLA
 142375308 Unknown KLA 18.33 19.27 25.23 27.01 26.13 21.96 6.28
ATP .93 .96 1.25 1.62 4.21 13.24 6.23
KLA/ATP 18.14 20.17 25.25 25.64 23.63 21.18 26.75
Nme1
KLA  ATP  ATP+KLA
 NM_008704 non-metastatic cells 1, protein (NM23A) expressed in (Nme1), mRNA [NM_008704] KLA .82 .85 .74 .76 .64 .62 .69
ATP .92 .94 1.26 1.20 1.08 .69 1.01
KLA/ATP .78 .84 1.03 .91 .92 .60 .31
Nme2
KLA  ATP  ATP+KLA
 NM_001077529 non-metastatic cells 2, protein (NM23B) expressed in (Nme2), transcript variant 2, mRNA [NM_001077529] KLA .96 .98 .93 .97 .84 .87 .80
ATP .97 .89 1.13 1.04 1.05 1.08 .56
KLA/ATP .95 .95 1.07 1.10 1.06 1.02 .53
Nme3
KLA  ATP  ATP+KLA
 NM_019730 non-metastatic cells 3, protein expressed in (Nme3), mRNA [NM_019730] KLA .74 .77 .74 .64 .53 .37 .29
ATP 1.03 1.05 1.14 1.30 1.07 .75 .75
KLA/ATP .79 .82 .84 1.01 .84 .64 .44
Nme4
KLA  ATP  ATP+KLA
 NM_019731 non-metastatic cells 4, protein expressed in (Nme4), mRNA [NM_019731] KLA .85 .85 .78 .75 .68 .56 .61
ATP .98 1.09 1.08 1.37 .89 .43 .43
KLA/ATP .89 .84 .76 1.08 .70 .48 .26
Nme5
KLA  ATP  ATP+KLA
 NM_080637 non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) (Nme5), mRNA [NM_080637] KLA .96 1.00 .99 1.00 1.03 1.02 1.02
ATP 1.01 1.05 1.04 1.03 1.00 1.00 1.05
KLA/ATP 1.06 .98 1.00 .95 1.03 .98 1.05
Nme6
KLA  ATP  ATP+KLA
 NM_018757 non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) (Nme6), mRNA [NM_018757] KLA .72 .79 .85 .86 .96 1.12 1.75
ATP .94 .95 1.01 .97 .65 .71 .95
KLA/ATP .77 .77 .73 .77 .63 .63 .95
Nme7
KLA  ATP  ATP+KLA
 NM_138314 non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) (Nme7), transcript variant 1, mRNA [NM_138314] KLA .78 .77 .80 .93 1.07 1.28 .98
ATP .95 .89 1.00 .88 .63 1.11 1.22
KLA/ATP .73 .77 .81 .72 .77 1.83 1.30
Nt5c
KLA  ATP  ATP+KLA
 NM_015807 5,3-nucleotidase, cytosolic (Nt5c), mRNA [NM_015807] KLA .81 .85 .74 .73 .75 .83 1.14
ATP .94 .90 .95 .96 .58 .52 1.07
KLA/ATP .78 .79 .82 .88 .65 .43 .68
Nt5c1b
KLA  ATP  ATP+KLA
 NM_027588 5-nucleotidase, cytosolic IB (Nt5c1b), mRNA [NM_027588] KLA 1.00 .98 .99 .99 1.00 1.02 1.00
ATP .98 1.02 1.01 .99 1.02 1.00 .94
KLA/ATP 1.01 1.02 .90 1.00 1.09 1.02 1.05
Nt5c2
KLA  ATP  ATP+KLA
 NM_029810 5-nucleotidase, cytosolic II (Nt5c2), mRNA [NM_029810] KLA .68 .66 .66 .62 .73 1.00 .79
ATP .98 1.02 1.06 .95 .65 .73 1.16
KLA/ATP .66 .68 .67 .61 .57 .80 1.07
Nt5c3
KLA  ATP  ATP+KLA
 NM_026004 5-nucleotidase, cytosolic III (Nt5c3), mRNA [NM_026004] KLA 19.31 19.80 19.18 17.01 11.84 11.21 4.96
ATP .98 .97 1.14 1.55 2.72 4.79 2.27
KLA/ATP 18.71 19.81 24.58 21.68 18.82 17.51 13.49
Nt5c3l
KLA  ATP  ATP+KLA
 NM_026561 5-nucleotidase, cytosolic III-like (Nt5c3l), transcript variant 2, mRNA [NM_026561] KLA .94 .91 .95 .90 .80 .79 .91
ATP .94 1.07 1.12 1.08 .86 .71 .87
KLA/ATP .97 .97 .88 .97 .83 .77 .67
Nt5e
KLA  ATP  ATP+KLA
 NM_011851 5 nucleotidase, ecto (Nt5e), mRNA [NM_011851] KLA .96 1.02 1.00 .95 1.00 .99 .99
ATP .98 .99 1.05 1.02 1.04 1.03 1.11
KLA/ATP .97 .99 .96 .95 .96 .99 1.04
Nt5m
KLA  ATP  ATP+KLA
 NM_134029 5,3-nucleotidase, mitochondrial (Nt5m), nuclear gene encoding mitochondrial protein, mRNA [NM_134029] KLA .73 .78 .92 1.14 1.54 2.01 1.80
ATP 1.02 1.06 .94 1.05 .73 .63 1.43
KLA/ATP .73 .76 .74 .85 .77 .87 1.50
Nudt2
KLA  ATP  ATP+KLA
 NM_025539 nudix (nucleoside diphosphate linked moiety X)-type motif 2 (Nudt2), mRNA [NM_025539] KLA .94 1.01 .93 .92 .94 .87 1.00
ATP .95 1.07 1.10 1.28 .86 .59 1.13
KLA/ATP .96 .98 .97 1.23 .89 .60 .74
Pnp1
KLA  ATP  ATP+KLA
 NM_013632 purine-nucleoside phosphorylase 1 (Pnp1), mRNA [NM_013632] KLA 5.68 5.47 6.37 7.13 8.25 8.23 3.96
ATP 1.15 1.04 1.14 1.52 1.68 3.22 3.33
KLA/ATP 5.61 5.86 7.11 8.09 8.18 8.72 9.32
Pnpt1
KLA  ATP  ATP+KLA
 AK085482 0 day neonate kidney cDNA, RIKEN full-length enriched library, clone:D630033G07 product:unclassifiable, full insert sequence. [AK085482] KLA .98 1.03 1.04 .98 1.03 1.03 1.01
ATP .97 .98 .96 1.02 .95 1.01 .98
KLA/ATP 1.02 1.08 1.01 1.00 1.00 1.06 1.03
Pnpt1
KLA  ATP  ATP+KLA
 NM_027869 polyribonucleotide nucleotidyltransferase 1 (Pnpt1), mRNA [NM_027869] KLA 3.44 3.41 4.04 3.56 2.94 2.53 2.01
ATP 1.06 1.07 1.19 1.24 .74 1.53 1.24
KLA/ATP 3.55 4.25 4.40 4.20 2.57 2.41 2.01
Pola1
KLA  ATP  ATP+KLA
 NM_008892 polymerase (DNA directed), alpha 1 (Pola1), mRNA [NM_008892] KLA .72 .68 .59 .56 .27 .19 .21
ATP .81 .97 1.41 1.22 .71 .29 .16
KLA/ATP .58 .70 .81 .56 .39 .27 .12
Pola2
KLA  ATP  ATP+KLA
 BC006945 polymerase (DNA directed), alpha 2, mRNA (cDNA clone MGC:11533 IMAGE:3602559), complete cds [BC006945] KLA .74 .76 .70 .74 .88 .91 .98
ATP .99 1.03 .83 .78 .96 .76 .92
KLA/ATP .67 .69 .65 .77 .88 .83 1.02
Pola2
KLA  ATP  ATP+KLA
 NM_008893 polymerase (DNA directed), alpha 2 (Pola2), mRNA [NM_008893] KLA .82 .76 .91 .72 .73 .74 .85
ATP 1.12 1.12 .88 1.20 .86 .82 .64
KLA/ATP .89 .84 .75 .84 .78 .91 1.16
Pold1
KLA  ATP  ATP+KLA
 NM_011131 polymerase (DNA directed), delta 1, catalytic subunit (Pold1), mRNA [NM_011131] KLA .24 .21 .20 .18 .18 .29 .36
ATP 1.05 1.05 .96 .99 .52 .26 .32
KLA/ATP .26 .22 .21 .22 .16 .17 .18
Pold2
KLA  ATP  ATP+KLA
 NM_008894 polymerase (DNA directed), delta 2, regulatory subunit (Pold2), mRNA [NM_008894] KLA .77 .83 .69 .68 .59 .49 .57
ATP 1.05 1.09 .97 1.24 .89 .44 .43
KLA/ATP .79 .78 .70 .84 .60 .41 .30
Pold3
KLA  ATP  ATP+KLA
 NM_133692 polymerase (DNA-directed), delta 3, accessory subunit (Pold3), mRNA [NM_133692] KLA 1.14 1.07 1.22 1.22 1.12 1.40 1.10
ATP .99 .95 1.17 .89 1.46 1.74 1.55
KLA/ATP 1.01 1.08 1.54 1.28 1.86 2.34 2.11
Pold4
KLA  ATP  ATP+KLA
 NM_027196 polymerase (DNA-directed), delta 4 (Pold4), mRNA [NM_027196] KLA .81 .88 .80 .78 .85 1.04 1.40
ATP .97 1.07 1.12 1.37 1.19 .86 1.27
KLA/ATP .85 .90 .89 1.07 .90 .94 1.62
Pole
KLA  ATP  ATP+KLA
 AK086490 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930032B21 product:DNA polymerase epsilon, full insert sequence. [AK086490] KLA 1.00 1.00 1.04 .96 .94 .99 1.04
ATP .97 .95 .91 .95 .97 1.06 .95
KLA/ATP .96 .93 1.00 1.01 1.08 1.02 1.01
Pole
KLA  ATP  ATP+KLA
 NM_011132 polymerase (DNA directed), epsilon (Pole), mRNA [NM_011132] KLA .50 .44 .38 .31 .25 .21 .17
ATP 1.12 1.03 1.28 .89 .68 .30 .16
KLA/ATP .45 .44 .56 .38 .30 .21 .14
Pole2
KLA  ATP  ATP+KLA
 NM_011133 polymerase (DNA directed), epsilon 2 (p59 subunit) (Pole2), mRNA [NM_011133] KLA .25 .24 .22 .21 .21 .37 .34
ATP .93 .98 1.11 1.00 .36 .30 .35
KLA/ATP .22 .22 .29 .30 .26 .28 .19
Pole3
KLA  ATP  ATP+KLA
 BC034004 polymerase (DNA directed), epsilon 3 (p17 subunit), mRNA (cDNA clone IMAGE:5117478) [BC034004] KLA .69 .72 .63 .69 .68 .81 .61
ATP .91 .86 1.29 .96 .81 .94 .51
KLA/ATP .62 .54 .85 .64 .70 .75 .44
Pole3
KLA  ATP  ATP+KLA
 NM_021498 polymerase (DNA directed), epsilon 3 (p17 subunit) (Pole3), mRNA [NM_021498] KLA 1.14 1.14 1.23 1.36 1.18 1.15 1.01
ATP 1.02 .98 1.17 1.44 1.40 1.27 1.25
KLA/ATP 1.20 1.24 1.58 1.57 1.60 1.25 1.23
Pole4
KLA  ATP  ATP+KLA
 NM_025882 polymerase (DNA-directed), epsilon 4 (p12 subunit) (Pole4), mRNA [NM_025882] KLA 1.11 1.15 1.15 1.22 1.19 1.31 1.26
ATP 1.00 .99 1.36 1.32 1.34 1.19 .98
KLA/ATP 1.02 1.15 1.58 1.47 1.52 1.10 .85
Polr1e
KLA  ATP  ATP+KLA
 NM_022811 polymerase (RNA) I polypeptide E (Polr1e), mRNA [NM_022811] KLA 1.01 1.06 .93 .81 .72 .80 1.37
ATP 1.04 1.10 1.09 1.06 .68 1.06 .85
KLA/ATP 1.15 1.13 .87 .96 .60 .72 .56
Polr2a
KLA  ATP  ATP+KLA
 NM_009089 polymerase (RNA) II (DNA directed) polypeptide A (Polr2a), mRNA [NM_009089] KLA 1.21 1.16 1.15 1.16 1.16 1.25 1.12
ATP 1.00 1.09 1.07 1.39 1.35 1.28 1.16
KLA/ATP 1.20 1.18 1.26 1.30 1.30 1.51 1.37
Polr2b
KLA  ATP  ATP+KLA
 NM_153798 polymerase (RNA) II (DNA directed) polypeptide B (Polr2b), mRNA [NM_153798] KLA .91 .91 .92 .73 .77 .80 .83
ATP 1.09 1.18 .96 .80 .64 .75 .93
KLA/ATP 1.01 .98 .74 .74 .53 .72 .71
Polr2c
KLA  ATP  ATP+KLA
 NM_009090 polymerase (RNA) II (DNA directed) polypeptide C (Polr2c), mRNA [NM_009090] KLA 1.45 1.41 1.48 1.33 1.24 1.24 1.34
ATP .97 1.07 1.01 1.06 1.09 1.27 1.13
KLA/ATP 1.48 1.46 1.34 1.46 1.27 1.50 1.26
Polr2d
KLA  ATP  ATP+KLA
 NM_027101 polymerase (RNA) II (DNA directed) polypeptide D (Polr2d), transcript variant 2, mRNA [NM_027101] KLA .89 .90 .80 .87 .86 .94 .99
ATP .95 .95 1.15 1.05 .93 1.45 .80
KLA/ATP .81 .88 .99 .96 .99 1.33 .89
Polr2e
KLA  ATP  ATP+KLA
 AK010567 ES cells cDNA, RIKEN full-length enriched library, clone:2410021N14 product:polymerase (RNA) II (DNA directed) polypeptide E, full insert sequence. [AK010567] KLA .67 .68 .68 .56 .58 .45 .67
ATP 1.14 1.18 1.05 1.26 .91 .63 .80
KLA/ATP .80 .77 .71 .81 .75 .50 .49
Polr2e
KLA  ATP  ATP+KLA
 NM_025554 polymerase (RNA) II (DNA directed) polypeptide E (Polr2e), mRNA [NM_025554] KLA .69 .74 .69 .61 .56 .49 .70
ATP 1.00 1.06 1.02 1.20 .88 .67 .73
KLA/ATP .79 .76 .72 .80 .77 .55 .45
Polr2f
KLA  ATP  ATP+KLA
 NM_027231 polymerase (RNA) II (DNA directed) polypeptide F (Polr2f), mRNA [NM_027231] KLA 1.01 .99 .92 .94 .86 .78 .84
ATP .94 1.00 1.18 1.34 1.14 .88 .91
KLA/ATP .96 1.07 1.23 1.38 1.16 .96 .70
Polr2g
KLA  ATP  ATP+KLA
 NM_026329 polymerase (RNA) II (DNA directed) polypeptide G (Polr2g), mRNA [NM_026329] KLA 2.39 2.22 2.36 2.22 1.69 1.12 1.08
ATP .93 .91 1.27 1.12 1.19 1.43 1.23
KLA/ATP 2.24 2.26 3.23 2.51 3.15 2.36 1.54
Polr2h
KLA  ATP  ATP+KLA
 NM_145632 polymerase (RNA) II (DNA directed) polypeptide H (Polr2h), mRNA [NM_145632] KLA .80 .76 .66 .62 .73 .87 1.14
ATP .90 .91 1.01 .99 1.10 1.32 .98
KLA/ATP .68 .72 .69 .65 .90 1.01 .62
Polr2i
KLA  ATP  ATP+KLA
 NM_027259 polymerase (RNA) II (DNA directed) polypeptide I (Polr2i), mRNA [NM_027259] KLA .67 .69 .68 .78 .80 .90 .99
ATP .98 .88 1.10 .84 .77 1.13 1.17
KLA/ATP .64 .68 .85 .70 .91 1.10 1.03
Polr2j
KLA  ATP  ATP+KLA
 NM_011293 polymerase (RNA) II (DNA directed) polypeptide J (Polr2j), mRNA [NM_011293] KLA .96 .89 .88 1.01 .88 .92 .85
ATP 1.09 1.12 1.38 1.58 1.39 1.15 .89
KLA/ATP 1.05 1.05 1.46 1.33 1.51 1.25 .88
Polr2l
KLA  ATP  ATP+KLA
 XM_888022 gb|PREDICTED: Mus musculus polymerase (RNA) II (DNA directed) polypeptide L (Polr2l), mRNA [XM_888022] KLA .82 .92 .85 .82 .77 .73 .88
ATP .95 1.00 1.15 1.42 1.20 .91 .99
KLA/ATP .86 .89 1.04 1.23 1.25 .91 .59
Polr3a
KLA  ATP  ATP+KLA
 AK039440 adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330043C08 product:hypothetical protein, full insert sequence. [AK039440] KLA 1.02 .94 .96 .97 1.13 .97 1.02
ATP .71 .55 .59 .69 .88 .93 .94
KLA/ATP .81 .65 .65 .80 .83 .88 .75
Polr3a
KLA  ATP  ATP+KLA
 NM_001081247 polymerase (RNA) III (DNA directed) polypeptide A (Polr3a), mRNA [NM_001081247] KLA 1.16 1.20 1.27 1.15 1.26 1.17 1.32
ATP .98 1.08 1.07 .92 .80 .99 1.26
KLA/ATP 1.22 1.30 1.18 .99 .78 1.24 1.27
Polr3b
KLA  ATP  ATP+KLA
 NM_027423 polymerase (RNA) III (DNA directed) polypeptide B (Polr3b), mRNA [NM_027423] KLA 1.03 1.05 1.02 1.07 1.11 1.15 1.05
ATP 1.09 1.15 .96 .97 .73 .75 .93
KLA/ATP 1.04 1.12 1.00 1.00 .74 .75 .77
Polr3c
KLA  ATP  ATP+KLA
 XM_131049 gb|PREDICTED: Mus musculus polymerase (RNA) III (DNA directed) polypeptide C, transcript variant 1 (Polr3c), mRNA [XM_131049] KLA 2.33 2.34 2.59 2.37 2.10 1.82 1.42
ATP 1.02 .97 1.12 1.19 .99 1.10 1.14
KLA/ATP 2.34 2.54 2.70 2.54 2.18 1.75 1.88
Polr3d
KLA  ATP  ATP+KLA
 NM_025945 polymerase (RNA) III (DNA directed) polypeptide D (Polr3d), mRNA [NM_025945] KLA 1.08 1.08 .90 .88 .98 .99 1.60
ATP .95 1.00 .94 .89 1.23 1.19 1.21
KLA/ATP 1.06 1.13 .88 .82 .68 .72 .55
Polr3e
KLA  ATP  ATP+KLA
 AK162059 adult male adrenal gland cDNA, RIKEN full-length enriched library, clone:7330401M11 product:sex-lethal interactor homolog (Drosophila), full insert sequence [AK162059] KLA .48 .46 .37 .33 .47 .53 .72
ATP 1.06 .96 .57 .49 .65 .27 .29
KLA/ATP .54 .43 .28 .37 .44 .27 .18
Polr3e
KLA  ATP  ATP+KLA
 NM_025298 polymerase (RNA) III (DNA directed) polypeptide E (Polr3e), mRNA [NM_025298] KLA .66 .69 .61 .58 .65 .72 1.37
ATP 1.01 .95 .80 .74 .58 .58 1.01
KLA/ATP .71 .69 .52 .57 .46 .42 .49
Polr3f
KLA  ATP  ATP+KLA
 NM_029763 polymerase (RNA) III (DNA directed) polypeptide F (Polr3f), mRNA [NM_029763] KLA 1.10 1.09 1.09 .98 .95 1.00 1.08
ATP 1.07 1.06 .84 .69 .72 .94 1.06
KLA/ATP 1.13 1.08 .80 .71 .70 .92 .92
Polr3g
KLA  ATP  ATP+KLA
 NM_001081176 polymerase (RNA) III (DNA directed) polypeptide G (Polr3g), mRNA [NM_001081176] KLA .51 .53 .43 .45 .41 .45 .57
ATP .90 .84 .68 .55 .54 .64 .60
KLA/ATP .51 .47 .46 .50 .48 .53 .46
Polr3gl
KLA  ATP  ATP+KLA
 NM_027241 polymerase (RNA) III (DNA directed) polypeptide G like (Polr3gl), mRNA [NM_027241] KLA .60 .51 .54 .55 .57 .70 .53
ATP .99 .86 1.08 .84 .48 .57 .69
KLA/ATP .55 .49 .64 .50 .53 .57 .67
Polr3h
KLA  ATP  ATP+KLA
 NM_030229 polymerase (RNA) III (DNA directed) polypeptide H (Polr3h), mRNA [NM_030229] KLA .89 .85 .75 .81 .76 .85 1.01
ATP .93 .81 .86 .71 .70 .93 .83
KLA/ATP .75 .78 .73 .70 .69 .76 .76
Polr3k
KLA  ATP  ATP+KLA
 NM_025901 polymerase (RNA) III (DNA directed) polypeptide K (Polr3k), mRNA [NM_025901] KLA .72 .72 .66 .69 .63 .74 .85
ATP .87 .84 1.14 .92 .64 .87 .72
KLA/ATP .65 .71 .90 .74 .65 .53 .44
Prim1
KLA  ATP  ATP+KLA
 NM_008921 DNA primase, p49 subunit (Prim1), mRNA [NM_008921] KLA .28 .26 .22 .18 .14 .24 .28
ATP .88 .80 1.35 .98 .50 .25 .26
KLA/ATP .22 .22 .33 .23 .20 .16 .10
Prim2
KLA  ATP  ATP+KLA
 NM_008922 DNA primase, p58 subunit (Prim2), mRNA [NM_008922] KLA .72 .68 .61 .54 .39 .52 .50
ATP .88 .76 .77 .64 .39 .47 .44
KLA/ATP .63 .59 .59 .44 .34 .46 .33
Rpo1-1
KLA  ATP  ATP+KLA
 NM_009085 RNA polymerase 1-1 (Rpo1-1), mRNA [NM_009085] KLA .77 .81 .81 .91 .90 .68 .86
ATP 1.03 .92 .86 .94 2.06 1.70 .91
KLA/ATP .82 .85 .86 .65 1.41 1.49 .92
Rpo1-2
KLA  ATP  ATP+KLA
 AK052672 0 day neonate kidney cDNA, RIKEN full-length enriched library, clone:D630020H17 product:RNA polymerase 1-2 (128 kDa subunit), full insert sequence. [AK052672] KLA 1.03 .94 1.03 1.01 .97 .97 1.00
ATP 1.01 1.00 .99 .94 1.02 .94 1.00
KLA/ATP 1.04 .98 .97 .89 1.01 1.02 .93
Rpo1-2
KLA  ATP  ATP+KLA
 NM_009086 RNA polymerase 1-2 (Rpo1-2), mRNA [NM_009086] KLA 1.64 1.60 1.10 .82 .62 .63 .98
ATP 1.04 1.17 .99 .79 .50 .59 .91
KLA/ATP 1.21 1.54 1.15 .76 .37 .61 .50
Rpo1-3
KLA  ATP  ATP+KLA
 NM_009087 RNA polymerase 1-3 (Rpo1-3), transcript variant 1, mRNA [NM_009087] KLA 1.00 .98 .86 .90 .95 .76 .93
ATP 1.07 1.09 1.20 1.26 1.26 1.12 .99
KLA/ATP .89 1.04 1.10 1.08 1.01 .71 .67
Rpo1-3
KLA  ATP  ATP+KLA
 NM_181730 RNA polymerase 1-3 (Rpo1-3), transcript variant 2, mRNA [NM_181730] KLA 1.06 1.17 1.07 1.08 .99 1.04 .98
ATP .93 .97 1.12 1.27 1.36 1.31 .82
KLA/ATP 1.02 1.06 1.20 1.31 1.28 1.32 .90
Rpo1-4
KLA  ATP  ATP+KLA
 NM_009088 RNA polymerase 1-4 (Rpo1-4), mRNA [NM_009088] KLA .75 .68 .58 .60 .46 .53 1.06
ATP 1.07 .98 1.22 1.00 .69 .74 .75
KLA/ATP .68 .65 .76 .61 .45 .34 .49
Rrm1
KLA  ATP  ATP+KLA
 AK049601 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530001L22 product:ribonucleotide reductase M1, full insert sequence. [AK049601] KLA .99 .96 1.17 1.00 1.00 .88 .97
ATP 1.07 .98 .94 .96 .92 .86 .99
KLA/ATP 1.00 1.03 1.00 .96 1.02 1.00 .95
Rrm1
KLA  ATP  ATP+KLA
 NM_009103 ribonucleotide reductase M1 (Rrm1), mRNA [NM_009103] KLA .47 .46 .38 .28 .18 .21 .17
ATP .97 1.01 1.06 .97 .65 .27 .18
KLA/ATP .46 .42 .39 .36 .23 .16 .11
Rrm2
KLA  ATP  ATP+KLA
 NM_009104 ribonucleotide reductase M2 (Rrm2), mRNA [NM_009104] KLA .32 .27 .23 .17 .13 .13 .12
ATP .98 1.00 1.17 1.28 .66 .20 .08
KLA/ATP .28 .25 .30 .30 .23 .13 .08
Rrm2b
KLA  ATP  ATP+KLA
 NM_199476 ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), mRNA [NM_199476] KLA .93 .90 .89 .95 .97 1.00 1.13
ATP .96 .95 .95 .87 .75 .80 .90
KLA/ATP .84 .85 .89 .84 .78 .78 .88
Tk1
KLA  ATP  ATP+KLA
 NM_009387 thymidine kinase 1 (Tk1), mRNA [NM_009387] KLA .36 .36 .31 .23 .18 .15 .14
ATP 1.04 1.13 .91 1.21 .52 .15 .09
KLA/ATP .39 .35 .29 .35 .22 .14 .11
Tk2
KLA  ATP  ATP+KLA
 NM_021028 thymidine kinase 2, mitochondrial (Tk2), nuclear gene encoding mitochondrial protein, mRNA [NM_021028] KLA .49 .53 .48 .66 .84 1.01 .86
ATP 1.07 1.02 .91 .96 .52 .41 .73
KLA/ATP .51 .48 .44 .46 .44 .56 .75
Twistnb
KLA  ATP  ATP+KLA
 NM_172253 TWIST neighbor (Twistnb), mRNA [NM_172253] KLA 1.30 1.25 1.07 .87 .82 .80 1.03
ATP 1.10 1.00 .92 .87 1.26 1.07 .94
KLA/ATP 1.29 1.21 1.09 .82 .79 .85 .59
Txnrd1
KLA  ATP  ATP+KLA
 NM_001042523 thioredoxin reductase 1 (Txnrd1), transcript variant 1, mRNA [NM_001042523] KLA 1.52 1.48 1.01 .65 .59 .68 .96
ATP .97 .98 .74 .89 3.11 6.97 1.02
KLA/ATP 1.41 1.37 .78 .72 1.65 4.48 1.36
Txnrd2
KLA  ATP  ATP+KLA
 AK008004 adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010001F03 product:ADULT MALE SMALL INTESTINE CDNA, RIKEN FULL-LENGTH ENRICHED LIBRARY, CLONE:2010001F03, FULL INSERT SEQUENCE, full insert sequence. [AK008004] KLA 1.35 1.23 1.26 1.32 1.07 1.01 .94
ATP .91 .87 1.52 1.79 1.51 1.21 1.00
KLA/ATP 1.15 1.41 2.12 1.88 1.76 1.23 .91
Txnrd2
KLA  ATP  ATP+KLA
 NM_013711 thioredoxin reductase 2 (Txnrd2), nuclear gene encoding mitochondrial protein, mRNA [NM_013711] KLA .84 .83 .83 .78 .75 .64 .92
ATP 1.12 1.20 1.08 1.25 .87 .44 .88
KLA/ATP .95 .90 .82 .93 .65 .43 .50
Txnrd3
KLA  ATP  ATP+KLA
 NM_153162 thioredoxin reductase 3 (Txnrd3), mRNA [NM_153162] KLA .99 .95 .69 .52 .49 .61 1.04
ATP .95 1.01 .95 .86 1.80 1.87 1.10
KLA/ATP .99 .89 .72 .72 1.20 1.46 .82
Tymp
KLA  ATP  ATP+KLA
 NM_138302 thymidine phosphorylase (Tymp), mRNA [NM_138302] KLA .41 .42 .37 .39 .51 .66 1.18
ATP 1.04 1.00 .86 1.08 1.04 1.25 1.40
KLA/ATP .46 .43 .34 .49 .56 .79 .64
Tyms
KLA  ATP  ATP+KLA
 NM_021288 thymidylate synthase (Tyms), mRNA [NM_021288] KLA .82 .81 .75 .71 .48 .30 .16
ATP 1.00 .94 1.32 1.26 .91 .52 .18
KLA/ATP .77 .73 1.07 .96 .80 .38 .18
Tyms
KLA  ATP  ATP+KLA
 X14489 gb|M.musculus thymidylate synthase (TS) gene exons 5 - 7. [X14489] KLA .87 .84 .91 .93 .93 .94 .77
ATP .99 .93 .95 .91 .94 .83 .79
KLA/ATP .87 .89 .92 .82 .85 .87 .85
Uck1
KLA  ATP  ATP+KLA
 NM_011675 uridine-cytidine kinase 1 (Uck1), mRNA [NM_011675] KLA .58 .60 .69 .76 .92 1.21 1.07
ATP .88 .96 .87 .78 .85 1.54 1.20
KLA/ATP .55 .59 .63 .62 .83 1.60 1.58
Uck2
KLA  ATP  ATP+KLA
 BC004016 uridine-cytidine kinase 2, mRNA (cDNA clone IMAGE:3493906), partial cds [BC004016] KLA .64 .62 .54 .44 .28 .23 .17
ATP .89 .94 1.31 1.78 2.23 2.61 .31
KLA/ATP .58 .57 .64 .67 .72 .95 .40
Uck2
KLA  ATP  ATP+KLA
 NM_030724 uridine-cytidine kinase 2 (Uck2), mRNA [NM_030724] KLA .95 .96 .77 .68 .37 .25 .10
ATP .90 .94 1.56 1.98 2.14 5.67 1.10
KLA/ATP .90 .93 1.09 1.15 .95 1.39 1.71
Uckl1
KLA  ATP  ATP+KLA
 NM_026765 uridine-cytidine kinase 1-like 1 (Uckl1), mRNA [NM_026765] KLA .97 .94 .95 1.01 .99 1.20 1.40
ATP .86 .85 .97 .84 .82 .65 1.12
KLA/ATP .89 .85 1.00 .86 .95 .76 1.37
Umps
KLA  ATP  ATP+KLA
 NM_009471 uridine monophosphate synthetase (Umps), mRNA [NM_009471] KLA .43 .42 .37 .41 .44 .66 .83
ATP 1.14 1.06 1.07 1.01 .89 .60 1.03
KLA/ATP .44 .44 .46 .45 .60 .56 .79
Upb1
KLA  ATP  ATP+KLA
 NM_133995 ureidopropionase, beta (Upb1), mRNA [NM_133995] KLA 1.22 1.30 1.23 1.20 1.25 1.21 1.15
ATP 1.06 1.13 1.16 1.14 1.01 1.57 1.24
KLA/ATP 1.23 1.24 1.29 1.26 1.18 1.91 2.90
Upp1
KLA  ATP  ATP+KLA
 NM_009477 uridine phosphorylase 1 (Upp1), mRNA [NM_009477] KLA 1.68 1.67 2.20 2.12 1.95 1.34 1.12
ATP .96 1.07 1.02 1.03 1.04 1.25 1.12
KLA/ATP 1.72 1.64 1.49 1.49 1.47 1.44 1.32
Upp2
KLA  ATP  ATP+KLA
 NM_029692 uridine phosphorylase 2 (Upp2), mRNA [NM_029692] KLA 1.01 1.05 1.04 1.05 1.04 1.04 1.01
ATP 1.06 1.00 1.05 1.01 1.00 1.00 1.03
KLA/ATP 1.05 1.02 1.07 1.03 1.05 1.10 1.04
Znrd1
KLA  ATP  ATP+KLA
 NM_023162 zinc ribbon domain containing, 1 (Znrd1), mRNA [NM_023162] KLA 1.04 1.12 1.28 1.43 1.67 1.76 1.39
ATP 1.01 1.08 1.13 1.34 .81 1.14 1.30
KLA/ATP 1.00 1.16 1.22 1.53 1.21 1.74 1.97