Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Phenylalanine metabolism (mmu00360)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
1700055N
04Rik
KLA  ATP  ATP+KLA
 AK081788 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130077J09 product:weakly similar to ALDEHYDE DEHYDROGENASE 7 (EC 1.2.1.5) [Homo sapiens], full insert sequence [AK081788] KLA .96 .98 .95 .97 .97 .96 1.06
ATP 1.01 1.00 .97 1.10 .95 .99 1.02
KLA/ATP .99 1.00 .97 1.00 1.00 .96 .97
4930438A
08Rik
KLA  ATP  ATP+KLA
 XM_001477470 gb|PREDICTED: Mus musculus RIKEN cDNA 4930438A08 gene (4930438A08Rik), mRNA [XM_001477470] KLA 1.78 1.45 1.69 1.62 1.69 1.48 1.31
ATP 1.07 1.04 1.24 1.13 1.13 1.61 1.67
KLA/ATP 1.83 1.46 1.58 1.30 1.43 1.36 1.95
Aldh1a3
KLA  ATP  ATP+KLA
 AK086764 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930050B08 product:aldehyde dehydrogenase family 1, subfamily A3, full insert sequence. [AK086764] KLA .97 1.05 1.05 1.01 1.00 .98 .97
ATP 1.00 1.03 .99 .92 1.01 1.09 1.02
KLA/ATP 1.01 .99 1.06 1.00 .97 .98 1.00
Aldh1a3
KLA  ATP  ATP+KLA
 NM_053080 aldehyde dehydrogenase family 1, subfamily A3 (Aldh1a3), mRNA [NM_053080] KLA 1.03 .96 1.03 1.03 .96 .98 1.01
ATP .98 1.04 1.01 1.06 .98 1.01 1.08
KLA/ATP 1.02 1.00 1.02 .94 1.03 .99 .99
Aldh3a1
KLA  ATP  ATP+KLA
 NM_007436 aldehyde dehydrogenase family 3, subfamily A1 (Aldh3a1), transcript variant 1, mRNA [NM_007436] KLA .98 .98 1.03 1.01 1.03 1.04 .97
ATP .98 1.01 1.06 .95 1.00 .96 1.02
KLA/ATP 1.07 1.08 .99 .98 1.03 .93 .98
Aldh3b1
KLA  ATP  ATP+KLA
 NM_026316 aldehyde dehydrogenase 3 family, member B1 (Aldh3b1), mRNA [NM_026316] KLA .82 .77 .69 .77 .72 .97 1.31
ATP .88 .85 1.13 .89 .71 .56 1.25
KLA/ATP .66 .72 .84 .66 .66 .52 1.17
Aldh3b2
KLA  ATP  ATP+KLA
 XM_129134 gb|PREDICTED: Mus musculus aldehyde dehydrogenase 3 family, member B2 (Aldh3b2), mRNA [XM_129134] KLA .91 .93 .85 .88 1.01 .99 1.37
ATP 1.12 1.11 .99 1.19 .87 .61 1.31
KLA/ATP .86 1.02 .90 1.01 .72 .54 1.21
Aoc2
KLA  ATP  ATP+KLA
 NM_178932 amine oxidase, copper containing 2 (retina-specific) (Aoc2), mRNA [NM_178932] KLA 1.21 1.19 1.15 1.00 1.15 1.21 1.18
ATP 1.13 1.13 1.14 1.36 1.85 1.32 .76
KLA/ATP 1.27 1.34 1.12 1.32 1.67 1.37 1.05
Aoc3
KLA  ATP  ATP+KLA
 NM_009675 amine oxidase, copper containing 3 (Aoc3), mRNA [NM_009675] KLA .95 1.06 1.00 1.05 1.00 1.02 1.01
ATP 1.01 .90 1.04 1.07 1.06 1.06 .97
KLA/ATP 1.06 .98 .92 1.10 1.11 1.09 1.01
Ddc
KLA  ATP  ATP+KLA
 NM_016672 dopa decarboxylase (Ddc), mRNA [NM_016672] KLA 1.27 1.28 1.34 1.33 1.34 1.21 1.05
ATP 1.02 .99 1.05 .98 1.02 1.02 1.14
KLA/ATP 1.24 1.22 1.28 1.25 1.12 1.20 1.35
Glyat
KLA  ATP  ATP+KLA
 BC015294 glycine-N-acyltransferase, mRNA (cDNA clone MGC:19155 IMAGE:4220471), complete cds [BC015294] KLA 1.09 1.02 .98 1.09 1.05 1.06 1.01
ATP 1.01 1.05 1.07 1.03 1.01 1.01 1.07
KLA/ATP 1.02 .97 1.03 .96 1.04 1.02 .99
Glyat
KLA  ATP  ATP+KLA
 NM_145935 glycine-N-acyltransferase (Glyat), nuclear gene encoding mitochondrial protein, mRNA [NM_145935] KLA 1.03 1.06 .99 1.00 .99 .98 1.11
ATP .99 1.00 1.00 1.27 1.18 1.11 1.10
KLA/ATP .97 .95 .95 1.46 1.47 1.14 1.09
Got1
KLA  ATP  ATP+KLA
 NM_010324 glutamate oxaloacetate transaminase 1, soluble (Got1), mRNA [NM_010324] KLA .68 .70 .66 .56 .50 .57 .99
ATP 1.01 1.24 1.55 1.59 1.47 1.03 1.68
KLA/ATP .68 .71 .66 .77 1.13 2.33 1.89
Got2
KLA  ATP  ATP+KLA
 NM_010325 glutamate oxaloacetate transaminase 2, mitochondrial (Got2), nuclear gene encoding mitochondrial protein, mRNA [NM_010325] KLA .84 .86 .88 .75 .75 .63 .61
ATP 1.02 1.12 .98 1.15 .98 .67 .86
KLA/ATP .92 .89 .75 .89 .68 .70 .77
Hpd
KLA  ATP  ATP+KLA
 NM_008277 4-hydroxyphenylpyruvic acid dioxygenase (Hpd), mRNA [NM_008277] KLA .94 1.10 1.04 1.02 .97 .97 1.06
ATP 1.05 1.07 .96 1.01 1.09 .97 1.01
KLA/ATP 1.02 1.03 1.12 1.00 .98 1.06 1.02
Il4i1
KLA  ATP  ATP+KLA
 NM_010215 interleukin 4 induced 1 (Il4i1), mRNA [NM_010215] KLA 13.98 13.74 14.90 14.92 13.89 12.12 3.25
ATP 1.02 .98 1.14 1.59 4.45 6.63 2.41
KLA/ATP 16.09 15.56 19.65 19.66 18.47 14.84 12.99
Lao1
KLA  ATP  ATP+KLA
 NM_133892 L-amino acid oxidase 1 (Lao1), mRNA [NM_133892] KLA 1.03 1.03 1.04 1.00 .98 1.01 .98
ATP 1.01 1.03 1.02 .92 1.05 .98 .99
KLA/ATP 1.02 .96 1.04 .94 .96 .97 .97
Maoa
KLA  ATP  ATP+KLA
 NM_173740 monoamine oxidase A (Maoa), nuclear gene encoding mitochondrial protein, mRNA [NM_173740] KLA 1.14 1.11 1.06 1.07 .84 .55 .53
ATP 1.10 1.07 1.33 1.20 1.44 2.37 1.38
KLA/ATP .97 1.11 1.75 1.33 1.27 1.21 1.09
Maob
KLA  ATP  ATP+KLA
 NM_172778 monoamine oxidase B (Maob), nuclear gene encoding mitochondrial protein, mRNA [NM_172778] KLA 1.01 .97 1.01 1.05 1.01 .95 1.01
ATP 1.09 .98 .99 .97 1.03 1.03 .94
KLA/ATP 1.02 1.05 .99 1.02 1.00 .98 .98
Mif
KLA  ATP  ATP+KLA
 NM_010798 macrophage migration inhibitory factor (Mif), mRNA [NM_010798] KLA .91 1.04 1.03 .89 1.01 .87 1.06
ATP 1.10 1.26 .98 1.34 1.22 1.11 .92
KLA/ATP 1.06 1.15 .85 1.30 1.09 1.17 1.08
Mm.26684
3
KLA  ATP  ATP+KLA
 94405693 Unknown KLA 1.12 .99 .99 1.00 .97 .98 .96
ATP 1.02 1.08 1.01 .90 1.02 .97 .91
KLA/ATP 1.03 .96 .98 .91 1.05 .90 .97
Mm.34137
KLA  ATP  ATP+KLA
 94405716 Unknown KLA 1.11 1.12 1.10 1.07 1.08 1.13 1.36
ATP 1.09 1.14 1.01 1.25 .95 .79 1.23
KLA/ATP 1.01 1.24 .95 1.14 .83 .78 1.30
Pah
KLA  ATP  ATP+KLA
 NM_008777 phenylalanine hydroxylase (Pah), mRNA [NM_008777] KLA .99 .93 1.06 .99 1.01 .99 .98
ATP 1.09 1.02 .99 .95 .97 .98 .99
KLA/ATP .97 .93 .97 .95 .95 1.00 .87
Prdx6
KLA  ATP  ATP+KLA
 AK081980 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130091B17 product:peroxiredoxin 5, related sequence 3, full insert sequence [AK081980] KLA 1.61 1.58 .92 .93 .93 1.08 1.24
ATP 2.61 2.91 4.18 6.45 12.41 12.74 3.19
KLA/ATP 2.79 4.31 7.52 6.17 5.64 6.93 5.25
Prdx6
KLA  ATP  ATP+KLA
 NM_007453 peroxiredoxin 6 (Prdx6), mRNA [NM_007453] KLA 1.33 1.40 1.49 1.32 1.28 1.04 .90
ATP 1.07 1.22 1.15 1.46 2.77 9.93 8.48
KLA/ATP 1.36 1.59 1.61 1.96 1.90 5.10 9.06
Tat
KLA  ATP  ATP+KLA
 NM_146214 tyrosine aminotransferase (Tat), nuclear gene encoding mitochondrial protein, mRNA [NM_146214] KLA 1.13 1.09 1.19 1.17 1.14 1.19 1.10
ATP .97 1.08 1.12 1.25 1.02 1.16 1.18
KLA/ATP 1.16 1.21 1.27 1.23 1.22 1.11 1.08