Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Tryptophan metabolism (mmu00380)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
4930438A
08Rik
KLA  ATP  ATP+KLA
 XM_001477470 gb|PREDICTED: Mus musculus RIKEN cDNA 4930438A08 gene (4930438A08Rik), mRNA [XM_001477470] KLA 1.78 1.45 1.69 1.62 1.69 1.48 1.31
ATP 1.07 1.04 1.24 1.13 1.13 1.61 1.67
KLA/ATP 1.83 1.46 1.58 1.30 1.43 1.36 1.95
Aadat
KLA  ATP  ATP+KLA
 NM_011834 aminoadipate aminotransferase (Aadat), mRNA [NM_011834] KLA 1.05 1.06 1.04 .98 1.00 1.04 .98
ATP .98 .99 1.10 1.03 1.00 1.04 1.03
KLA/ATP 1.05 1.09 1.07 1.04 .97 1.06 1.05
Aanat
KLA  ATP  ATP+KLA
 NM_009591 arylalkylamine N-acetyltransferase (Aanat), mRNA [NM_009591] KLA 1.04 1.01 1.17 1.06 .96 1.09 .99
ATP .99 1.02 1.01 .99 1.01 .92 .99
KLA/ATP 1.01 1.06 1.01 1.04 .99 .99 1.02
Abp1
KLA  ATP  ATP+KLA
 NM_029638 amiloride binding protein 1 (amine oxidase, copper-containing) (Abp1), mRNA [NM_029638] KLA 1.18 1.09 .99 1.08 1.08 .96 1.03
ATP 1.01 1.02 1.01 .97 1.00 1.00 1.05
KLA/ATP 1.14 1.10 1.12 1.02 .99 1.04 1.14
Acat1
KLA  ATP  ATP+KLA
 NM_144784 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA 1.04 .99 .95 .99 .81 .83 .51
ATP .89 .88 1.21 .99 .67 .36 .47
KLA/ATP .86 .97 1.18 .90 .64 .42 .35
Acat2
KLA  ATP  ATP+KLA
 NM_009338 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA 1.14 1.13 1.22 1.29 1.10 .93 .81
ATP 1.04 1.05 1.16 1.35 1.20 1.53 1.16
KLA/ATP 1.19 1.19 1.41 1.29 1.13 .92 .71
Acmsd
KLA  ATP  ATP+KLA
 NM_001033041 amino carboxymuconate semialdehyde decarboxylase (Acmsd), mRNA [NM_001033041] KLA 1.03 1.05 .97 1.03 1.06 .95 .88
ATP .93 .99 1.03 1.00 .95 1.04 1.00
KLA/ATP .97 .89 1.07 1.03 .95 .91 .95
Afmid
KLA  ATP  ATP+KLA
 NM_027827 arylformamidase (Afmid), mRNA [NM_027827] KLA .85 .95 .89 .82 1.00 1.22 1.18
ATP 1.06 1.11 1.05 1.16 1.11 .95 .69
KLA/ATP .96 1.09 .95 1.06 1.00 .99 .91
Aldh1b1
KLA  ATP  ATP+KLA
 NM_028270 aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA [NM_028270] KLA 7.51 7.83 9.27 11.57 11.10 10.78 4.79
ATP .93 .91 .90 .89 .73 2.27 2.30
KLA/ATP 6.45 7.40 9.33 9.54 8.82 12.15 10.67
Aldh2
KLA  ATP  ATP+KLA
 AK163452 adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230105J09 product:aldehyde dehydrogenase 2, mitochondrial, full insert sequence [AK163452] KLA .62 .65 .59 .60 .63 .64 .49
ATP 1.01 .91 1.06 .93 1.18 .93 .41
KLA/ATP .70 .68 .70 .84 1.16 .96 .45
Aldh2
KLA  ATP  ATP+KLA
 NM_009656 aldehyde dehydrogenase 2, mitochondrial (Aldh2), nuclear gene encoding mitochondrial protein, mRNA [NM_009656] KLA .74 .81 .77 .65 .60 .53 .50
ATP .98 1.10 .90 1.17 1.04 .82 .60
KLA/ATP .84 .86 .77 .82 .72 .66 .51
Aldh3a2
KLA  ATP  ATP+KLA
 NM_007437 aldehyde dehydrogenase family 3, subfamily A2 (Aldh3a2), mRNA [NM_007437] KLA .86 .83 .79 .79 .80 .97 1.00
ATP .93 .98 .94 .89 .77 .87 1.02
KLA/ATP .78 .81 .67 .72 .65 .81 .97
Aldh7a1
KLA  ATP  ATP+KLA
 NM_138600 aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600] KLA .98 1.03 1.08 1.12 1.08 .94 .99
ATP 1.01 1.03 1.00 1.03 .98 .82 .91
KLA/ATP 1.15 1.12 1.01 1.02 .90 .89 .83
Aldh9a1
KLA  ATP  ATP+KLA
 NM_019993 aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993] KLA .64 .64 .67 .48 .42 .24 .33
ATP 1.07 1.02 .75 .94 .68 .46 .42
KLA/ATP .72 .65 .43 .55 .37 .31 .24
Aox1
KLA  ATP  ATP+KLA
 NM_009676 aldehyde oxidase 1 (Aox1), mRNA [NM_009676] KLA .87 .83 .82 .82 .71 .98 1.65
ATP 1.01 1.02 1.05 .84 .72 .86 .80
KLA/ATP .82 .84 .90 .73 .72 .82 1.06
Aox3
KLA  ATP  ATP+KLA
 NM_023617 aldehyde oxidase 3 (Aox3), mRNA [NM_023617] KLA .95 1.02 1.01 1.00 .99 1.01 1.04
ATP 1.04 1.03 1.01 .94 1.03 .92 .96
KLA/ATP 1.09 1.11 1.00 .97 .95 1.01 .94
Aox4
KLA  ATP  ATP+KLA
 NM_023631 aldehyde oxidase 4 (Aox4), mRNA [NM_023631] KLA .95 .97 .98 1.00 .98 .91 1.06
ATP .93 .99 .95 .99 .94 .95 1.00
KLA/ATP 1.05 1.00 .94 .98 .89 1.00 .93
Cat
KLA  ATP  ATP+KLA
 NM_009804 catalase (Cat), mRNA [NM_009804] KLA .63 .67 .67 .45 .36 .21 .43
ATP 1.10 1.25 .91 1.01 .78 1.28 .84
KLA/ATP .75 .69 .43 .59 .35 .72 .87
Ccbl1
KLA  ATP  ATP+KLA
 NM_172404 cysteine conjugate-beta lyase 1 (Ccbl1), mRNA [NM_172404] KLA .68 .64 .61 .59 .58 .75 .89
ATP 1.02 .96 .89 .80 .63 .48 .97
KLA/ATP .71 .68 .61 .64 .53 .50 .60
Ccbl2
KLA  ATP  ATP+KLA
 NM_173763 cysteine conjugate-beta lyase 2 (Ccbl2), mRNA [NM_173763] KLA 2.01 2.14 2.03 1.98 1.40 .85 .65
ATP .96 .91 1.14 .95 .81 1.04 .68
KLA/ATP 2.05 2.10 2.27 1.79 1.55 1.00 .57
Cyp1a1
KLA  ATP  ATP+KLA
 NM_009992 cytochrome P450, family 1, subfamily a, polypeptide 1 (Cyp1a1), mRNA [NM_009992] KLA 1.07 .99 1.02 1.01 1.00 1.00 1.11
ATP .99 1.02 1.01 .95 .96 .94 1.09
KLA/ATP 1.01 1.03 .98 .96 .96 .95 1.51
Cyp1a2
KLA  ATP  ATP+KLA
 NM_009993 cytochrome P450, family 1, subfamily a, polypeptide 2 (Cyp1a2), mRNA [NM_009993] KLA 1.01 .99 .98 1.02 .97 .97 1.00
ATP 1.01 .98 1.03 1.01 1.04 1.02 1.04
KLA/ATP .99 1.00 1.05 1.03 .98 .97 .99
Cyp1b1
KLA  ATP  ATP+KLA
 AK016699 adult male testis cDNA, RIKEN full-length enriched library, clone:4933406K16 product:cytochrome P450, 1b1, benz[a]anthracene inducible, full insert sequence. [AK016699] KLA 1.00 1.03 1.00 1.02 1.02 .97 1.03
ATP 1.00 1.04 1.03 1.13 1.04 1.05 1.02
KLA/ATP 1.06 1.03 .96 1.05 1.07 1.12 1.09
Cyp1b1
KLA  ATP  ATP+KLA
 NM_009994 cytochrome P450, family 1, subfamily b, polypeptide 1 (Cyp1b1), mRNA [NM_009994] KLA 1.02 .99 1.04 1.05 .98 1.00 1.07
ATP 1.05 1.01 1.05 1.19 1.09 2.31 5.32
KLA/ATP .99 1.02 1.05 1.06 1.14 1.39 3.15
Ddc
KLA  ATP  ATP+KLA
 NM_016672 dopa decarboxylase (Ddc), mRNA [NM_016672] KLA 1.27 1.28 1.34 1.33 1.34 1.21 1.05
ATP 1.02 .99 1.05 .98 1.02 1.02 1.14
KLA/ATP 1.24 1.22 1.28 1.25 1.12 1.20 1.35
Echs1
KLA  ATP  ATP+KLA
 NM_053119 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial (Echs1), nuclear gene encoding mitochondrial protein, mRNA [NM_053119] KLA .57 .55 .52 .54 .60 .82 .90
ATP .99 .97 1.07 1.15 .77 .37 .81
KLA/ATP .55 .56 .55 .66 .53 .39 .41
Ehhadh
KLA  ATP  ATP+KLA
 NM_023737 enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (Ehhadh), mRNA [NM_023737] KLA .74 .77 .80 .88 .71 .67 .74
ATP 1.02 1.06 1.04 .90 .70 .84 .83
KLA/ATP .79 .81 .80 .65 .59 .79 .55
Gcdh
KLA  ATP  ATP+KLA
 U18992 glutaryl-CoA dehydrogenase mRNA, complete cds. [U18992] KLA .93 .79 .71 .83 .76 .74 .79
ATP 1.03 1.08 1.25 1.15 .86 .56 .75
KLA/ATP .72 .82 1.12 .93 .68 .50 .48
Hadh
KLA  ATP  ATP+KLA
 NM_008212 hydroxyacyl-Coenzyme A dehydrogenase (Hadh), nuclear gene encoding mitochondrial protein, mRNA [NM_008212] KLA .75 .75 .72 .64 .54 .37 .49
ATP 1.12 1.19 1.08 1.28 .96 .43 .41
KLA/ATP .76 .81 .68 .85 .56 .42 .21
Hadha
KLA  ATP  ATP+KLA
 AK050856 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert KLA .96 .92 .91 .80 .97 .92 .90
ATP .72 .64 .63 .71 .91 .93 .93
KLA/ATP .79 .72 .68 .73 .87 .90 .88
Hadha
KLA  ATP  ATP+KLA
 NM_178878 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878] KLA 1.10 1.17 1.36 1.16 1.23 1.10 1.00
ATP 1.16 1.22 1.03 1.40 1.09 .79 1.11
KLA/ATP 1.33 1.35 1.16 1.41 1.00 .92 1.31
Il4i1
KLA  ATP  ATP+KLA
 NM_010215 interleukin 4 induced 1 (Il4i1), mRNA [NM_010215] KLA 13.98 13.74 14.90 14.92 13.89 12.12 3.25
ATP 1.02 .98 1.14 1.59 4.45 6.63 2.41
KLA/ATP 16.09 15.56 19.65 19.66 18.47 14.84 12.99
Indo
KLA  ATP  ATP+KLA
 NM_008324 indoleamine-pyrrole 2,3 dioxygenase (Indo), mRNA [NM_008324] KLA 1.56 1.62 1.87 1.73 1.52 1.38 1.28
ATP 1.09 1.01 1.08 1.02 1.00 1.06 1.07
KLA/ATP 1.53 1.60 1.78 1.50 1.49 1.40 3.38
Indol1
KLA  ATP  ATP+KLA
 NM_145949 indoleamine-pyrrole 2,3 dioxygenase-like 1 (Indol1), mRNA [NM_145949] KLA 2.01 2.13 2.31 2.13 2.14 2.14 2.52
ATP .96 .98 1.06 1.12 .99 1.18 1.25
KLA/ATP 2.03 2.15 1.83 1.54 1.38 1.32 2.07
Inmt
KLA  ATP  ATP+KLA
 NM_009349 indolethylamine N-methyltransferase (Inmt), mRNA [NM_009349] KLA 1.93 2.09 2.34 2.04 2.49 1.90 1.81
ATP .97 1.13 .96 1.21 1.04 1.02 1.40
KLA/ATP 2.00 2.00 1.37 1.91 1.41 1.31 1.62
Kmo
KLA  ATP  ATP+KLA
 NM_133809 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (Kmo), mRNA [NM_133809] KLA 2.27 2.39 2.79 2.51 2.33 1.55 .70
ATP .95 1.15 1.11 1.08 .94 .98 .63
KLA/ATP 2.15 2.35 2.11 1.65 1.33 1.30 .72
Kynu
KLA  ATP  ATP+KLA
 BC026950 kynureninase (L-kynurenine hydrolase), mRNA (cDNA clone MGC:30315 IMAGE:5136970), complete cds. [BC026950] KLA .99 1.04 1.04 1.02 1.11 1.05 .98
ATP 1.06 1.00 1.01 1.04 1.08 .99 .97
KLA/ATP 1.08 1.07 .95 .99 1.06 1.11 1.02
Kynu
KLA  ATP  ATP+KLA
 NM_027552 kynureninase (L-kynurenine hydrolase) (Kynu), mRNA [NM_027552] KLA 1.86 1.93 2.04 1.85 1.45 1.18 1.10
ATP .99 1.01 1.05 1.12 1.00 1.03 1.09
KLA/ATP 1.84 1.75 2.04 1.63 1.46 1.26 1.27
Lao1
KLA  ATP  ATP+KLA
 NM_133892 L-amino acid oxidase 1 (Lao1), mRNA [NM_133892] KLA 1.03 1.03 1.04 1.00 .98 1.01 .98
ATP 1.01 1.03 1.02 .92 1.05 .98 .99
KLA/ATP 1.02 .96 1.04 .94 .96 .97 .97
Maoa
KLA  ATP  ATP+KLA
 NM_173740 monoamine oxidase A (Maoa), nuclear gene encoding mitochondrial protein, mRNA [NM_173740] KLA 1.14 1.11 1.06 1.07 .84 .55 .53
ATP 1.10 1.07 1.33 1.20 1.44 2.37 1.38
KLA/ATP .97 1.11 1.75 1.33 1.27 1.21 1.09
Maob
KLA  ATP  ATP+KLA
 NM_172778 monoamine oxidase B (Maob), nuclear gene encoding mitochondrial protein, mRNA [NM_172778] KLA 1.01 .97 1.01 1.05 1.01 .95 1.01
ATP 1.09 .98 .99 .97 1.03 1.03 .94
KLA/ATP 1.02 1.05 .99 1.02 1.00 .98 .98
Mm.27395
8
KLA  ATP  ATP+KLA
 31560783 Unknown KLA .84 .82 .82 .88 1.05 1.14 1.07
ATP 1.36 1.47 1.11 1.14 1.07 .85 .81
KLA/ATP .97 .93 .90 1.13 1.05 .99 1.01
Mm.29323
3
KLA  ATP  ATP+KLA
 118130035 Unknown KLA .98 1.04 .98 1.05 1.07 .97 .95
ATP 1.02 1.04 1.01 1.02 1.00 1.00 1.00
KLA/ATP 1.03 1.00 .98 .96 1.10 1.03 .98
Mm.31830
2
KLA  ATP  ATP+KLA
 124487482 Unknown KLA 1.02 1.02 1.02 1.06 1.03 .98 1.05
ATP 1.00 .99 1.04 1.17 1.04 .98 .96
KLA/ATP 1.04 1.02 1.22 1.05 .99 .99 .99
Ogdh
KLA  ATP  ATP+KLA
 NM_010956 oxoglutarate dehydrogenase (lipoamide) (Ogdh), nuclear gene encoding mitochondrial protein, mRNA [NM_010956] KLA 1.00 1.05 1.10 .95 1.06 1.08 1.30
ATP 1.10 1.28 .95 1.23 .93 1.15 1.82
KLA/ATP 1.27 1.11 .81 1.21 .76 1.13 1.83
Ogdhl
KLA  ATP  ATP+KLA
 NM_001081130 oxoglutarate dehydrogenase-like (Ogdhl), mRNA [NM_001081130] KLA 1.03 1.07 1.03 1.02 1.00 .97 .91
ATP .94 .99 .98 .99 .93 .99 1.01
KLA/ATP .97 1.02 1.03 .93 .95 .90 1.04
Tdo2
KLA  ATP  ATP+KLA
 NM_019911 tryptophan 2,3-dioxygenase (Tdo2), mRNA [NM_019911] KLA .99 1.04 1.03 .98 1.08 1.01 1.02
ATP .98 1.01 .99 .98 1.06 1.06 1.04
KLA/ATP 1.06 .95 1.06 1.02 1.02 1.00 .98
Tph1
KLA  ATP  ATP+KLA
 NM_009414 tryptophan hydroxylase 1 (Tph1), mRNA [NM_009414] KLA .99 1.02 1.03 1.03 1.01 1.00 1.03
ATP 1.07 1.04 1.01 1.02 .99 .98 .98
KLA/ATP 1.00 1.07 1.05 1.37 1.20 1.03 .99
Tph2
KLA  ATP  ATP+KLA
 AY090565 neuronal tryptophan hydroxylase (Ntph) mRNA, complete cds [AY090565] KLA 1.01 .98 .98 1.05 .96 .97 1.05
ATP .94 1.04 .95 .93 .97 .91 .95
KLA/ATP 1.06 1.07 .99 .99 1.05 1.06 .98