Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Glycosaminoglycan degradation (mmu00531)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
AK209324
KLA  ATP  ATP+KLA
 AK209324 cDNA, clone:Y2G0114L23, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000060207, based on BLAT search. [AK209324] KLA .48 .51 .55 .57 .80 .90 1.17
ATP 1.01 .96 .73 .60 .76 .78 1.24
KLA/ATP .54 .46 .42 .54 .76 .76 .73
Arsb
KLA  ATP  ATP+KLA
 AK083309 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:C920003D12 product:arylsulfatase B structural, full insert sequence. [AK083309] KLA .99 .88 .99 .93 .92 .98 1.00
ATP 1.07 1.12 1.10 .95 1.01 .97 .90
KLA/ATP .96 1.03 .95 .94 .94 .94 .99
Arsb
KLA  ATP  ATP+KLA
 NM_009712 arylsulfatase B (Arsb), mRNA [NM_009712] KLA 1.11 1.13 1.16 1.02 .93 .79 .60
ATP 1.04 1.21 1.12 1.46 1.00 .74 .56
KLA/ATP 1.20 1.32 1.05 1.33 .84 .72 .54
Galns
KLA  ATP  ATP+KLA
 NM_016722 galactosamine (N-acetyl)-6-sulfate sulfatase (Galns), mRNA [NM_016722] KLA .99 1.00 1.06 1.00 1.07 1.14 1.41
ATP 1.18 1.19 .97 1.33 1.03 .80 1.15
KLA/ATP 1.11 1.12 .96 1.38 .85 .83 1.55
Glb1
KLA  ATP  ATP+KLA
 NM_009752 galactosidase, beta 1 (Glb1), mRNA [NM_009752] KLA .93 .96 1.02 .85 .86 .81 .80
ATP 1.03 1.10 1.01 1.13 .97 .82 .75
KLA/ATP 1.08 1.04 .86 1.06 .81 .81 .66
Gns
KLA  ATP  ATP+KLA
 AK040524 0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430105C13 product:glucosamine (N-acetyl)-6-sulfatase, full insert sequence. [AK040524] KLA 2.06 2.05 1.93 2.03 2.37 1.56 1.22
ATP 1.18 1.15 .98 2.24 1.28 1.03 1.52
KLA/ATP 2.15 2.20 1.53 2.63 1.61 1.42 1.54
Gns
KLA  ATP  ATP+KLA
 NM_029364 glucosamine (N-acetyl)-6-sulfatase (Gns), mRNA [NM_029364] KLA 1.48 1.47 1.80 1.48 1.81 2.03 1.87
ATP 1.09 1.27 .92 1.16 .95 .85 1.54
KLA/ATP 1.57 1.62 1.22 1.69 .98 1.34 1.93
Gusb
KLA  ATP  ATP+KLA
 NM_010368 glucuronidase, beta (Gusb), mRNA [NM_010368] KLA .65 .67 .62 .52 .52 .47 .52
ATP 1.07 1.11 .95 1.00 .80 .57 .58
KLA/ATP .72 .71 .56 .62 .52 .48 .38
Hexa
KLA  ATP  ATP+KLA
 NM_010421 hexosaminidase A (Hexa), mRNA [NM_010421] KLA .74 .76 .70 .63 .57 .52 .51
ATP .98 1.04 .82 .81 .68 .52 .64
KLA/ATP .76 .78 .63 .60 .48 .37 .31
Hexb
KLA  ATP  ATP+KLA
 NM_010422 hexosaminidase B (Hexb), mRNA [NM_010422] KLA .82 .90 .81 .70 .64 .64 .71
ATP .95 1.03 1.11 .83 .72 .58 .63
KLA/ATP .80 .83 .77 .68 .53 .45 .50
Hgsnat
KLA  ATP  ATP+KLA
 NM_029884 heparan-alpha-glucosaminide N-acetyltransferase (Hgsnat), mRNA [NM_029884] KLA .73 .74 .73 .76 .70 1.27 1.85
ATP .91 .98 1.13 1.21 1.13 1.59 2.63
KLA/ATP .69 .68 .78 .98 1.06 2.45 4.56
Hpse
KLA  ATP  ATP+KLA
 NM_152803 heparanase (Hpse), mRNA [NM_152803] KLA 1.99 1.93 2.60 2.97 2.72 1.99 1.34
ATP 1.17 1.20 1.06 1.43 1.25 .98 1.30
KLA/ATP 2.23 2.49 2.45 2.70 1.84 2.05 2.71
Hyal1
KLA  ATP  ATP+KLA
 NM_008317 hyaluronoglucosaminidase 1 (Hyal1), mRNA [NM_008317] KLA .31 .28 .26 .26 .29 .53 .76
ATP 1.03 1.03 .71 1.21 1.31 .46 3.39
KLA/ATP .31 .32 .33 .53 .84 .58 2.71
Hyal2
KLA  ATP  ATP+KLA
 NM_010489 hyaluronoglucosaminidase 2 (Hyal2), mRNA [NM_010489] KLA .34 .25 .21 .25 .32 .56 .91
ATP 1.07 .83 .83 .66 1.51 1.39 2.21
KLA/ATP .31 .25 .23 .20 .94 1.21 2.14
Hyal3
KLA  ATP  ATP+KLA
 NM_178020 hyaluronoglucosaminidase 3 (Hyal3), mRNA [NM_178020] KLA 1.07 1.00 .94 1.01 .99 1.03 1.03
ATP 1.03 1.06 2.20 4.46 3.50 1.36 1.02
KLA/ATP .98 .97 1.03 1.73 2.32 1.45 1.09
Hyal4
KLA  ATP  ATP+KLA
 AK014599 0 day neonate skin cDNA, RIKEN full-length enriched library, clone:4632428M18 product:similar to HYALURONIDASE 4 [Homo sapiens], full insert sequence [AK014599] KLA .95 .97 .88 .89 .91 .93 .90
ATP .96 .97 .97 .97 .91 1.02 .91
KLA/ATP .89 .88 .93 .93 .95 .97 .89
Hyal5
KLA  ATP  ATP+KLA
 NM_028957 hyaluronoglucosaminidase 5 (Hyal5), mRNA [NM_028957] KLA 1.02 1.02 1.01 .94 .96 1.06 1.05
ATP 1.01 1.00 .98 1.06 1.03 1.00 1.08
KLA/ATP 1.04 .97 1.00 1.01 1.11 1.02 1.05
Hyal6
KLA  ATP  ATP+KLA
 NM_028920 hyaluronoglucosaminidase 6 (Hyal6), mRNA [NM_028920] KLA .92 .96 .90 1.00 .99 .98 1.01
ATP 1.02 1.01 1.06 .98 1.07 .99 1.02
KLA/ATP .96 1.02 .97 1.01 1.03 1.06 .95
Ids
KLA  ATP  ATP+KLA
 NM_010498 iduronate 2-sulfatase (Ids), transcript variant 1, mRNA [NM_010498] KLA 1.25 1.29 1.33 1.30 1.22 1.23 1.13
ATP 1.02 1.11 1.09 1.09 .81 .64 .83
KLA/ATP 1.24 1.22 1.13 1.13 .78 .77 .86
Idua
KLA  ATP  ATP+KLA
 NM_008325 iduronidase, alpha-L- (Idua), mRNA [NM_008325] KLA .88 .91 1.00 .87 .91 1.00 1.22
ATP .97 1.03 .99 1.04 .89 .64 .85
KLA/ATP .93 .97 1.01 .97 .72 .63 .86
Mm.47565
8
KLA  ATP  ATP+KLA
 145966880 Unknown KLA .20 .19 .15 .15 .17 .47 .71
ATP .85 .82 .70 1.24 1.23 .39 3.48
KLA/ATP .18 .20 .18 .38 .85 .56 2.73
Naglu
KLA  ATP  ATP+KLA
 AK158045 adult inner ear cDNA, RIKEN full-length enriched library, clone:F930021C23 product:alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB), full insert sequence [AK158045] KLA 1.06 1.01 1.05 .98 1.02 1.04 1.01
ATP .99 1.05 .96 1.00 1.05 .93 1.03
KLA/ATP 1.03 .99 1.04 1.03 .96 .98 .91
Naglu
KLA  ATP  ATP+KLA
 NM_013792 alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) (Naglu), mRNA [NM_013792] KLA .67 .71 .71 .63 .59 .60 .87
ATP 1.02 1.07 1.00 1.14 .84 .57 .95
KLA/ATP .72 .72 .71 .84 .58 .54 .72
Sgsh
KLA  ATP  ATP+KLA
 NM_018822 N-sulfoglucosamine sulfohydrolase (sulfamidase) (Sgsh), mRNA [NM_018822] KLA .68 .66 .65 .65 .54 .61 .71
ATP 1.00 1.03 1.06 .98 .73 .59 .73
KLA/ATP .72 .67 .69 .66 .52 .56 .57
Spam1
KLA  ATP  ATP+KLA
 NM_001079875 sperm adhesion molecule 1 (Spam1), transcript variant 1, mRNA [NM_001079875] KLA 1.12 1.05 .98 1.05 1.02 1.03 1.07
ATP .96 1.02 .85 .96 .97 1.14 1.09
KLA/ATP .96 .95 1.03 1.01 .98 .92 1.03