Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Glycosylphosphatidylinositol(GPI)-anchor biosynthesis (mmu00563)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Dpm2
KLA  ATP  ATP+KLA
 NM_010073 dolichol-phosphate (beta-D) mannosyltransferase 2 (Dpm2), mRNA [NM_010073] KLA .83 .89 .88 .88 1.15 1.34 1.44
ATP .99 1.01 .87 .98 1.09 1.49 1.65
KLA/ATP .90 .82 .73 .93 1.04 1.74 2.55
Gpaa1
KLA  ATP  ATP+KLA
 NM_010331 GPI anchor attachment protein 1 (Gpaa1), mRNA [NM_010331] KLA .93 .99 .97 .99 .87 .85 .87
ATP 1.05 1.16 1.03 1.14 1.03 .85 .79
KLA/ATP 1.05 1.08 .96 1.01 .81 .89 .81
Gpld1
KLA  ATP  ATP+KLA
 NM_008156 glycosylphosphatidylinositol specific phospholipase D1 (Gpld1), mRNA [NM_008156] KLA .94 .91 .92 .99 .97 .99 .98
ATP .98 .92 .95 .99 .92 .95 .94
KLA/ATP 1.08 .92 .92 .94 .96 .98 .99
Mm.21700
4
KLA  ATP  ATP+KLA
 142350613 Unknown KLA 1.16 1.21 1.14 1.10 1.08 1.08 1.03
ATP 1.02 1.12 1.05 .94 .90 1.04 .89
KLA/ATP 1.19 1.11 1.09 1.02 .98 .94 .95
Mm.31988
1
KLA  ATP  ATP+KLA
 124486986 Unknown KLA 1.34 1.28 1.38 1.28 1.23 1.23 1.21
ATP 1.14 1.10 1.13 1.20 1.03 .97 1.01
KLA/ATP 1.31 1.39 1.42 1.28 1.13 .97 1.07
Mm.36205
4
KLA  ATP  ATP+KLA
 118130030 Unknown KLA .79 .80 .81 .73 .86 .82 .88
ATP 1.00 1.12 .89 .98 .70 .55 1.34
KLA/ATP .82 .85 .58 .75 .50 .63 .97
Pgap1
KLA  ATP  ATP+KLA
 AK033485 adult male colon cDNA, RIKEN full-length enriched library, clone:9030223K07 product:unclassifiable, full insert sequence. [AK033485] KLA .77 .76 .70 .72 .59 .60 1.13
ATP .92 1.04 1.03 .84 1.04 .78 .42
KLA/ATP .68 .76 .86 .69 1.00 .78 .84
Pgap1
KLA  ATP  ATP+KLA
 AK051360 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130039I04 product:hypothetical protein, full insert sequence [AK051360] KLA 1.03 1.03 1.03 1.08 1.02 1.03 1.13
ATP 1.06 1.09 .88 .90 1.02 .99 .99
KLA/ATP 1.00 .99 .91 .93 .99 .97 1.13
Piga
KLA  ATP  ATP+KLA
 NM_011081 phosphatidylinositol glycan anchor biosynthesis, class A (Piga), mRNA [NM_011081] KLA .93 .84 .81 .79 .69 .72 .89
ATP .95 .86 1.11 .77 .86 1.94 1.15
KLA/ATP .87 .77 .98 .63 .81 1.70 1.20
Pigb
KLA  ATP  ATP+KLA
 NM_018889 phosphatidylinositol glycan anchor biosynthesis, class B (Pigb), mRNA [NM_018889] KLA .89 .93 .93 .89 .99 .93 1.23
ATP 1.00 1.04 1.01 1.04 .82 .77 1.16
KLA/ATP .98 1.00 .85 .91 .81 .81 1.02
Pigc
KLA  ATP  ATP+KLA
 NM_026078 phosphatidylinositol glycan anchor biosynthesis, class C (Pigc), transcript variant 1, mRNA [NM_026078] KLA .80 .76 .78 .91 .94 1.11 1.05
ATP 1.04 .86 1.04 .77 .61 1.12 1.21
KLA/ATP .77 .72 .88 .58 .61 .72 1.16
Pigf
KLA  ATP  ATP+KLA
 NM_008838 phosphatidylinositol glycan anchor biosynthesis, class F (Pigf), mRNA [NM_008838] KLA 1.12 1.19 1.19 1.29 1.01 .87 .97
ATP .94 .96 1.47 1.40 1.17 1.12 .93
KLA/ATP 1.02 1.14 1.63 1.40 1.37 1.24 .75
Pigg
KLA  ATP  ATP+KLA
 BC051059 phosphatidylinositol glycan anchor biosynthesis, class G, mRNA (cDNA clone IMAGE:5010465), containing frame-shift errors. [BC051059] KLA 1.12 1.04 1.07 1.06 .91 .90 1.05
ATP .96 .91 1.06 .94 .69 .79 .92
KLA/ATP 1.06 1.09 1.07 .90 .82 .69 .85
Pigg
KLA  ATP  ATP+KLA
 NM_001081234 phosphatidylinositol glycan anchor biosynthesis, class G (Pigg), mRNA [NM_001081234] KLA 1.63 1.57 1.55 1.36 1.34 1.10 1.43
ATP 1.07 1.23 1.03 .99 .75 .68 1.36
KLA/ATP 1.67 1.83 1.41 1.40 .83 .68 1.18
Pigh
KLA  ATP  ATP+KLA
 NM_029988 phosphatidylinositol glycan anchor biosynthesis, class H (Pigh), mRNA [NM_029988] KLA .77 .84 .83 .83 .88 1.09 1.34
ATP .92 .93 .91 .90 .59 .61 1.20
KLA/ATP .71 .73 .70 .68 .60 .67 1.09
Pigk
KLA  ATP  ATP+KLA
 NM_178016 phosphatidylinositol glycan anchor biosynthesis, class K (Pigk), transcript variant 2, mRNA [NM_178016] KLA 1.23 1.40 1.38 1.35 1.21 1.09 1.30
ATP 1.02 1.03 1.15 1.32 1.11 .87 1.12
KLA/ATP 1.33 1.45 1.50 1.59 1.20 .88 .80
Pigl
KLA  ATP  ATP+KLA
 NM_001039536 phosphatidylinositol glycan anchor biosynthesis, class L (Pigl), mRNA [NM_001039536] KLA 1.15 1.24 1.19 1.07 1.29 1.27 1.91
ATP 1.05 1.24 1.09 1.17 .86 .88 1.83
KLA/ATP 1.21 1.18 .93 1.17 .87 .98 1.64
Pigm
KLA  ATP  ATP+KLA
 NM_026234 phosphatidylinositol glycan anchor biosynthesis, class M (Pigm), mRNA [NM_026234] KLA 1.13 1.22 1.28 1.15 1.20 1.10 1.16
ATP .99 1.04 .99 .98 .79 1.01 1.15
KLA/ATP 1.22 1.19 1.07 1.03 .80 .98 1.13
Pign
KLA  ATP  ATP+KLA
 AK082387 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230045A22 product:phosphatidylinositol glycan, class N, full insert sequence. [AK082387] KLA 1.05 .98 .94 1.00 .96 1.00 1.00
ATP .98 1.02 1.03 1.07 .95 .95 .93
KLA/ATP 1.06 1.01 1.01 1.02 .94 .97 1.03
Pign
KLA  ATP  ATP+KLA
 NM_013784 phosphatidylinositol glycan anchor biosynthesis, class N (Pign), mRNA [NM_013784] KLA 1.59 1.62 1.78 1.81 2.02 2.07 2.03
ATP 1.00 1.01 1.16 1.07 .95 1.29 1.37
KLA/ATP 1.58 1.75 1.75 1.40 1.16 1.29 1.65
Pigo
KLA  ATP  ATP+KLA
 NM_020035 phosphatidylinositol glycan anchor biosynthesis, class O (Pigo), mRNA [NM_020035] KLA .86 .89 .91 .80 .98 .90 1.17
ATP 1.07 1.10 .93 .95 .78 .90 1.61
KLA/ATP .94 .89 .77 .75 .66 1.00 1.65
Pigp
KLA  ATP  ATP+KLA
 NM_019543 phosphatidylinositol glycan anchor biosynthesis, class P (Pigp), mRNA [NM_019543] KLA .89 .83 .83 .84 .69 .64 .82
ATP .89 .84 1.33 1.23 .96 .60 .82
KLA/ATP .80 .83 1.01 1.02 .89 .61 .55
Pigq
KLA  ATP  ATP+KLA
 NM_011822 phosphatidylinositol glycan anchor biosynthesis, class Q (Pigq), mRNA [NM_011822] KLA .76 .86 .83 .76 .89 .88 .89
ATP 1.10 1.14 .89 .98 .72 .55 1.34
KLA/ATP .92 .83 .59 .78 .54 .61 1.01
Pigs
KLA  ATP  ATP+KLA
 NM_201406 phosphatidylinositol glycan anchor biosynthesis, class S (Pigs), mRNA [NM_201406] KLA .85 .81 .80 .82 .77 .73 .88
ATP 1.02 1.11 1.06 1.11 .88 .70 .94
KLA/ATP .89 .92 .82 .81 .56 .62 .93
Pigt
KLA  ATP  ATP+KLA
 NM_133779 phosphatidylinositol glycan anchor biosynthesis, class T (Pigt), mRNA [NM_133779] KLA 1.04 1.13 1.03 1.02 1.03 1.14 1.19
ATP 1.02 1.22 .89 1.09 .90 .82 .93
KLA/ATP 1.14 1.30 .86 1.06 .78 .87 .90
Pigu
KLA  ATP  ATP+KLA
 NM_001004721 phosphatidylinositol glycan anchor biosynthesis, class U (Pigu), mRNA [NM_001004721] KLA 1.05 1.10 1.07 .96 1.06 1.02 1.23
ATP 1.09 1.26 1.21 1.42 .99 .87 1.05
KLA/ATP 1.15 1.18 .98 1.28 .90 .83 1.05
Pigv
KLA  ATP  ATP+KLA
 NM_178698 phosphatidylinositol glycan anchor biosynthesis, class V (Pigv), mRNA [NM_178698] KLA 1.14 1.18 1.11 1.20 1.20 1.07 1.04
ATP 1.04 1.11 .98 .96 .91 1.06 .99
KLA/ATP 1.25 1.20 1.09 .98 1.00 .93 1.02
Pigw
KLA  ATP  ATP+KLA
 NM_027388 phosphatidylinositol glycan anchor biosynthesis, class W (Pigw), transcript variant 1, mRNA [NM_027388] KLA .87 .90 .79 .81 .80 .89 1.13
ATP .97 .97 .99 .84 .74 .87 1.12
KLA/ATP .78 .85 .87 .85 .81 .74 .88
Pigx
KLA  ATP  ATP+KLA
 NM_024464 phosphatidylinositol glycan anchor biosynthesis, class X (Pigx), transcript variant 1, mRNA [NM_024464] KLA 1.02 1.04 .99 .96 .94 .98 1.06
ATP .99 1.02 1.16 1.20 1.26 1.15 1.19
KLA/ATP .96 1.08 1.04 1.16 1.06 1.04 1.45
Pigz
KLA  ATP  ATP+KLA
 NM_172822 phosphatidylinositol glycan anchor biosynthesis, class Z (Pigz), mRNA [NM_172822] KLA .78 .70 .69 .75 .57 .76 1.18
ATP 1.01 .82 1.33 1.07 .88 .47 .67
KLA/ATP .70 .79 .90 .73 .66 .39 .34