Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Nicotinate and nicotinamide metabolism (mmu00760)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Aox1
KLA  ATP  ATP+KLA
 NM_009676 aldehyde oxidase 1 (Aox1), mRNA [NM_009676] KLA .87 .83 .82 .82 .71 .98 1.65
ATP 1.01 1.02 1.05 .84 .72 .86 .80
KLA/ATP .82 .84 .90 .73 .72 .82 1.06
Aox3
KLA  ATP  ATP+KLA
 NM_023617 aldehyde oxidase 3 (Aox3), mRNA [NM_023617] KLA .95 1.02 1.01 1.00 .99 1.01 1.04
ATP 1.04 1.03 1.01 .94 1.03 .92 .96
KLA/ATP 1.09 1.11 1.00 .97 .95 1.01 .94
Aox4
KLA  ATP  ATP+KLA
 NM_023631 aldehyde oxidase 4 (Aox4), mRNA [NM_023631] KLA .95 .97 .98 1.00 .98 .91 1.06
ATP .93 .99 .95 .99 .94 .95 1.00
KLA/ATP 1.05 1.00 .94 .98 .89 1.00 .93
BC016495
KLA  ATP  ATP+KLA
 NM_145497 cDNA sequence BC016495 (BC016495), mRNA [NM_145497] KLA .52 .52 .55 .48 .57 .93 .98
ATP 1.04 1.01 1.07 .91 .69 .97 1.41
KLA/ATP .60 .55 .59 .52 .46 .84 1.55
Bst1
KLA  ATP  ATP+KLA
 NM_009763 bone marrow stromal cell antigen 1 (Bst1), mRNA [NM_009763] KLA 2.26 2.15 2.90 3.73 4.89 5.96 6.57
ATP 1.05 1.06 1.31 1.52 1.57 4.31 4.76
KLA/ATP 2.29 2.31 3.10 2.98 3.09 5.35 13.91
Cd38
KLA  ATP  ATP+KLA
 NM_007646 CD38 antigen (Cd38), mRNA [NM_007646] KLA 3.61 5.39 8.63 9.62 24.42 36.25 76.13
ATP 1.00 1.05 1.36 1.70 2.26 8.41 7.84
KLA/ATP 4.45 4.89 5.01 7.93 5.74 14.08 40.05
Enpp1
KLA  ATP  ATP+KLA
 ENSMUST00000105520 ens|Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E- NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Lymphocyte antigen 41) (Ly-41) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1 KLA .71 .79 .64 .61 .55 .51 .32
ATP .85 .97 .85 .72 .62 .45 .28
KLA/ATP .72 .73 .61 .66 .60 .55 .27
Enpp1
KLA  ATP  ATP+KLA
 NM_008813 ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1), mRNA [NM_008813] KLA .82 .83 .77 .83 .65 .64 .51
ATP .89 .90 1.21 1.00 .98 .87 .64
KLA/ATP .72 .76 .96 .87 1.00 .94 .51
Enpp3
KLA  ATP  ATP+KLA
 BC005527 ectonucleotide pyrophosphatase [BC005527] KLA 1.06 .99 .98 1.01 .97 .99 .96
ATP .93 1.08 .99 1.05 .94 1.05 1.10
KLA/ATP .95 .96 1.10 .99 .95 .94 1.03
Enpp3
KLA  ATP  ATP+KLA
 BC006944 ectonucleotide pyrophosphatase/phosphodiesterase 3, mRNA (cDNA clone IMAGE:2655671), complete cds. [BC006944] KLA 1.02 1.01 1.03 1.08 1.04 1.01 1.01
ATP .97 1.01 .96 1.00 .98 1.07 .99
KLA/ATP 1.01 .99 1.07 1.02 .97 .98 .92
Enpp3
KLA  ATP  ATP+KLA
 NM_134005 ectonucleotide pyrophosphatase/phosphodiesterase 3 (Enpp3), mRNA [NM_134005] KLA 1.01 .95 .99 .98 1.05 1.04 .98
ATP .98 .98 1.03 .98 .96 1.00 .98
KLA/ATP .97 1.03 1.04 .93 1.02 .99 1.04
Itgb1bp3
KLA  ATP  ATP+KLA
 NM_027120 integrin beta 1 binding protein 3 (Itgb1bp3), mRNA [NM_027120] KLA 1.00 .97 1.03 1.01 .98 1.04 1.04
ATP 1.06 .95 1.01 .97 .97 1.01 1.03
KLA/ATP .94 1.03 1.04 .99 1.05 .92 1.05
Mm.17932
KLA  ATP  ATP+KLA
 142368657 Unknown KLA 1.96 2.16 2.26 2.04 1.94 2.22 1.33
ATP 1.19 1.29 2.96 4.36 1.42 1.27 1.16
KLA/ATP 4.95 7.89 18.00 12.21 3.38 1.85 1.27
Mm.24987
3
KLA  ATP  ATP+KLA
 161621251 Unknown KLA 1.11 1.02 1.08 1.36 1.47 1.64 3.59
ATP 1.05 1.00 1.00 .96 1.04 1.20 1.13
KLA/ATP 1.08 1.12 1.23 1.06 1.09 1.31 1.81
Mm.76062
KLA  ATP  ATP+KLA
 57527869 Unknown KLA 1.29 1.49 1.51 1.51 1.60 1.61 1.64
ATP .94 .88 .90 .96 .83 1.19 1.76
KLA/ATP 1.33 1.31 1.18 1.27 1.06 1.30 1.71
Nadk
KLA  ATP  ATP+KLA
 NM_138671 NAD kinase (Nadk), mRNA [NM_138671] KLA 1.14 1.21 1.18 1.21 1.38 1.48 2.34
ATP .92 .84 .67 .56 .61 .69 .91
KLA/ATP 1.07 .97 .76 .64 .56 .54 1.71
Nadsyn1
KLA  ATP  ATP+KLA
 NM_030221 NAD synthetase 1 (Nadsyn1), mRNA [NM_030221] KLA .94 .85 .89 .99 .96 1.02 .97
ATP .98 .95 1.19 .81 .73 .70 1.01
KLA/ATP .76 .87 1.17 .90 .82 .78 1.05
Nampt
KLA  ATP  ATP+KLA
 NM_021524 nicotinamide phosphoribosyltransferase (Nampt), mRNA [NM_021524] KLA 5.66 6.00 6.44 6.07 5.54 4.22 3.91
ATP 1.07 1.18 1.23 2.42 3.68 5.68 2.56
KLA/ATP 5.73 6.25 6.38 9.37 8.72 7.22 5.11
Naprt1
KLA  ATP  ATP+KLA
 NM_172607 nicotinate phosphoribosyltransferase domain containing 1 (Naprt1), mRNA [NM_172607] KLA .70 .62 .67 .62 .50 .46 .56
ATP 1.01 .90 1.12 .94 .58 .39 .76
KLA/ATP .69 .68 .82 .71 .60 .34 .42
Nmnat1
KLA  ATP  ATP+KLA
 AK152407 bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830068L10 product:NMN adenylyltransferase; nicotinamide mononucleotide adenylyl transferase, full insert sequence [AK152407] KLA 1.59 1.41 1.71 1.75 1.77 1.74 1.49
ATP .96 .88 1.13 1.05 .87 1.49 2.19
KLA/ATP 1.41 1.50 1.78 1.54 1.31 1.73 2.33
Nmnat2
KLA  ATP  ATP+KLA
 NM_175460 nicotinamide nucleotide adenylyltransferase 2 (Nmnat2), mRNA [NM_175460] KLA .98 .98 1.02 .98 .95 1.00 1.04
ATP 1.04 1.05 1.04 1.00 .94 .96 1.03
KLA/ATP 1.02 1.04 .99 1.00 1.00 1.03 1.02
Nmnat3
KLA  ATP  ATP+KLA
 NM_144533 nicotinamide nucleotide adenylyltransferase 3 (Nmnat3), mRNA [NM_144533] KLA .49 .44 .41 .40 .34 .52 .80
ATP .94 .82 1.02 .64 .63 .50 .72
KLA/ATP .42 .42 .41 .30 .56 .62 .42
Nnmt
KLA  ATP  ATP+KLA
 NM_010924 nicotinamide N-methyltransferase (Nnmt), mRNA [NM_010924] KLA .98 .99 1.03 .98 .98 1.01 1.00
ATP .92 1.03 1.04 1.02 1.04 5.10 5.18
KLA/ATP .96 1.03 1.04 1.03 .99 2.30 4.68
Nnt
KLA  ATP  ATP+KLA
 NM_008710 nicotinamide nucleotide transhydrogenase (Nnt), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA [NM_008710] KLA .90 .88 .87 .79 .72 .58 .50
ATP 1.10 1.11 1.11 .99 .76 .52 .41
KLA/ATP .94 .95 .85 .79 .59 .48 .30
Nnt
KLA  ATP  ATP+KLA
 Z49204 gb|M.musculus mRNA for NADP transhydrogenase. [Z49204] KLA .94 .91 1.05 .93 .79 .64 .54
ATP 1.15 1.17 1.23 1.09 .85 .47 .40
KLA/ATP 1.12 1.02 .91 .86 .62 .49 .30
Nt5c
KLA  ATP  ATP+KLA
 NM_015807 5,3-nucleotidase, cytosolic (Nt5c), mRNA [NM_015807] KLA .81 .85 .74 .73 .75 .83 1.14
ATP .94 .90 .95 .96 .58 .52 1.07
KLA/ATP .78 .79 .82 .88 .65 .43 .68
Nt5c1b
KLA  ATP  ATP+KLA
 NM_027588 5-nucleotidase, cytosolic IB (Nt5c1b), mRNA [NM_027588] KLA 1.00 .98 .99 .99 1.00 1.02 1.00
ATP .98 1.02 1.01 .99 1.02 1.00 .94
KLA/ATP 1.01 1.02 .90 1.00 1.09 1.02 1.05
Nt5c2
KLA  ATP  ATP+KLA
 NM_029810 5-nucleotidase, cytosolic II (Nt5c2), mRNA [NM_029810] KLA .68 .66 .66 .62 .73 1.00 .79
ATP .98 1.02 1.06 .95 .65 .73 1.16
KLA/ATP .66 .68 .67 .61 .57 .80 1.07
Nt5c3
KLA  ATP  ATP+KLA
 NM_026004 5-nucleotidase, cytosolic III (Nt5c3), mRNA [NM_026004] KLA 19.31 19.80 19.18 17.01 11.84 11.21 4.96
ATP .98 .97 1.14 1.55 2.72 4.79 2.27
KLA/ATP 18.71 19.81 24.58 21.68 18.82 17.51 13.49
Nt5c3l
KLA  ATP  ATP+KLA
 NM_026561 5-nucleotidase, cytosolic III-like (Nt5c3l), transcript variant 2, mRNA [NM_026561] KLA .94 .91 .95 .90 .80 .79 .91
ATP .94 1.07 1.12 1.08 .86 .71 .87
KLA/ATP .97 .97 .88 .97 .83 .77 .67
Nt5e
KLA  ATP  ATP+KLA
 NM_011851 5 nucleotidase, ecto (Nt5e), mRNA [NM_011851] KLA .96 1.02 1.00 .95 1.00 .99 .99
ATP .98 .99 1.05 1.02 1.04 1.03 1.11
KLA/ATP .97 .99 .96 .95 .96 .99 1.04
Nt5m
KLA  ATP  ATP+KLA
 NM_134029 5,3-nucleotidase, mitochondrial (Nt5m), nuclear gene encoding mitochondrial protein, mRNA [NM_134029] KLA .73 .78 .92 1.14 1.54 2.01 1.80
ATP 1.02 1.06 .94 1.05 .73 .63 1.43
KLA/ATP .73 .76 .74 .85 .77 .87 1.50
Nudt12
KLA  ATP  ATP+KLA
 NM_026497 nudix (nucleoside diphosphate linked moiety X)-type motif 12 (Nudt12), mRNA [NM_026497] KLA 1.01 .97 .94 .91 .85 .86 .94
ATP 1.00 1.01 1.02 .89 .82 .90 1.01
KLA/ATP .91 .98 .96 .89 .79 .87 1.02
Pnp1
KLA  ATP  ATP+KLA
 NM_013632 purine-nucleoside phosphorylase 1 (Pnp1), mRNA [NM_013632] KLA 5.68 5.47 6.37 7.13 8.25 8.23 3.96
ATP 1.15 1.04 1.14 1.52 1.68 3.22 3.33
KLA/ATP 5.61 5.86 7.11 8.09 8.18 8.72 9.32
Qprt
KLA  ATP  ATP+KLA
 NM_133686 quinolinate phosphoribosyltransferase (Qprt), mRNA [NM_133686] KLA 1.01 .99 .88 .93 1.07 .96 1.03
ATP 1.00 .95 1.04 .93 .98 1.05 .92
KLA/ATP 1.02 .97 .99 1.01 1.00 .94 .89