Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Mismatch repair (mmu03430)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
AK038264
KLA  ATP  ATP+KLA
 AK038264 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130091A22 product:unclassifiable, full insert sequence. [AK038264] KLA .96 1.05 1.06 .95 .98 1.07 1.05
ATP 1.01 1.02 .99 .98 .96 1.02 1.00
KLA/ATP 1.06 .96 .98 .97 1.05 1.08 1.39
Exo1
KLA  ATP  ATP+KLA
 NM_012012 exonuclease 1 (Exo1), mRNA [NM_012012] KLA .16 .15 .16 .13 .16 .25 .17
ATP 1.01 .95 .96 .41 .42 .31 .20
KLA/ATP .16 .13 .20 .17 .18 .17 .09
Lig1
KLA  ATP  ATP+KLA
 NM_010715 ligase I, DNA, ATP-dependent (Lig1), transcript variant 2, mRNA [NM_010715] KLA .53 .54 .51 .42 .30 .28 .27
ATP .97 .93 1.02 .96 .73 .29 .30
KLA/ATP .55 .50 .57 .48 .43 .26 .20
Mlh1
KLA  ATP  ATP+KLA
 NM_026810 mutL homolog 1 (E. coli) (Mlh1), mRNA [NM_026810] KLA .58 .55 .46 .47 .38 .49 .66
ATP .93 .95 1.06 1.02 .50 .80 .77
KLA/ATP .59 .56 .59 .55 .41 1.31 1.86
Mlh3
KLA  ATP  ATP+KLA
 NM_175337 mutL homolog 3 (E coli) (Mlh3), mRNA [NM_175337] KLA .68 .68 .65 .70 .70 .76 1.08
ATP 1.00 .92 .78 .58 .63 .84 1.45
KLA/ATP .64 .66 .63 .55 .55 .75 1.18
Mm.29073
KLA  ATP  ATP+KLA
 146141223 Unknown KLA .48 .44 .52 .52 .40 .48 .44
ATP 1.03 .81 1.38 1.13 .59 .41 .38
KLA/ATP .45 .50 .74 .47 .37 .41 .31
Mm.2950
KLA  ATP  ATP+KLA
 121583909 Unknown KLA .85 .79 .75 .75 .81 .75 .79
ATP .94 1.13 .91 .71 .69 .73 .78
KLA/ATP .78 .73 .79 .74 .71 .71 .67
Mm.38683
5
KLA  ATP  ATP+KLA
 21703947 Unknown KLA .41 .36 .37 .36 .33 .47 .36
ATP 1.06 .92 1.29 1.00 .55 .46 .34
KLA/ATP .41 .36 .50 .37 .32 .38 .24
Mm.42112
9
KLA  ATP  ATP+KLA
 133892806 Unknown KLA .56 .53 .50 .43 .25 .23 .19
ATP .91 .89 1.16 .93 .74 .27 .22
KLA/ATP .52 .48 .64 .47 .43 .21 .14
Msh2
KLA  ATP  ATP+KLA
 AK051960 12 days embryo eyeball cDNA, RIKEN full-length enriched library, clone:D230024H20 product:mutS homolog 2 (E. coli), full insert sequence. [AK051960] KLA .94 .92 .89 1.00 .94 .98 .95
ATP .94 .81 1.04 .93 .99 .97 1.05
KLA/ATP .98 .92 .99 .95 .97 1.04 1.00
Msh2
KLA  ATP  ATP+KLA
 AK078775 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030473G08 product:mutS homolog 2 (E. coli), full insert sequence. [AK078775] KLA .71 .69 .72 .67 .69 .68 .66
ATP 1.05 .94 .66 .65 .70 .64 .74
KLA/ATP .70 .69 .67 .67 .67 .64 .60
Msh2
KLA  ATP  ATP+KLA
 NM_008628 mutS homolog 2 (E. coli) (Msh2), mRNA [NM_008628] KLA .33 .29 .22 .18 .14 .21 .28
ATP .91 .86 1.26 .84 .51 .19 .29
KLA/ATP .28 .28 .33 .21 .18 .15 .09
Msh3
KLA  ATP  ATP+KLA
 NM_010829 mutS homolog 3 (E. coli) (Msh3), mRNA [NM_010829] KLA .92 .89 .96 1.08 1.08 1.22 1.16
ATP 1.03 1.04 .96 .91 .65 .77 .95
KLA/ATP .88 .92 .92 .88 .86 1.31 2.25
Msh6
KLA  ATP  ATP+KLA
 NM_010830 mutS homolog 6 (E. coli) (Msh6), mRNA [NM_010830] KLA .12 .11 .11 .12 .14 .31 .35
ATP .89 .77 .98 .51 .38 .49 .35
KLA/ATP .11 .11 .15 .12 .22 .40 .40
Pcna
KLA  ATP  ATP+KLA
 NM_011045 proliferating cell nuclear antigen (Pcna), mRNA [NM_011045] KLA .70 .69 .73 .56 .46 .66 .55
ATP .98 .95 1.12 .81 .74 .49 .92
KLA/ATP .69 .66 .78 .60 .63 .59 .62
Pms2
KLA  ATP  ATP+KLA
 NM_008886 postmeiotic segregation increased 2 (S. cerevisiae) (Pms2), mRNA [NM_008886] KLA .42 .43 .46 .51 .70 .69 .61
ATP 1.12 1.11 .78 .52 .37 .47 .55
KLA/ATP .47 .44 .47 .40 .38 .43 .40
Pold1
KLA  ATP  ATP+KLA
 NM_011131 polymerase (DNA directed), delta 1, catalytic subunit (Pold1), mRNA [NM_011131] KLA .24 .21 .20 .18 .18 .29 .36
ATP 1.05 1.05 .96 .99 .52 .26 .32
KLA/ATP .26 .22 .21 .22 .16 .17 .18
Pold2
KLA  ATP  ATP+KLA
 NM_008894 polymerase (DNA directed), delta 2, regulatory subunit (Pold2), mRNA [NM_008894] KLA .77 .83 .69 .68 .59 .49 .57
ATP 1.05 1.09 .97 1.24 .89 .44 .43
KLA/ATP .79 .78 .70 .84 .60 .41 .30
Pold3
KLA  ATP  ATP+KLA
 NM_133692 polymerase (DNA-directed), delta 3, accessory subunit (Pold3), mRNA [NM_133692] KLA 1.14 1.07 1.22 1.22 1.12 1.40 1.10
ATP .99 .95 1.17 .89 1.46 1.74 1.55
KLA/ATP 1.01 1.08 1.54 1.28 1.86 2.34 2.11
Pold4
KLA  ATP  ATP+KLA
 NM_027196 polymerase (DNA-directed), delta 4 (Pold4), mRNA [NM_027196] KLA .81 .88 .80 .78 .85 1.04 1.40
ATP .97 1.07 1.12 1.37 1.19 .86 1.27
KLA/ATP .85 .90 .89 1.07 .90 .94 1.62
Rfc1
KLA  ATP  ATP+KLA
 NM_011258 replication factor C (activator 1) 1 (Rfc1), mRNA [NM_011258] KLA .37 .35 .39 .42 .46 .67 .75
ATP .96 .95 1.13 .76 .45 .40 .62
KLA/ATP .36 .38 .42 .30 .29 .38 .36
Rfc2
KLA  ATP  ATP+KLA
 NM_020022 replication factor C (activator 1) 2 (Rfc2), mRNA [NM_020022] KLA .51 .52 .53 .57 .61 .86 .75
ATP .96 .91 1.11 1.11 .70 .35 .86
KLA/ATP .51 .50 .62 .54 .57 .56 .76
Rfc3
KLA  ATP  ATP+KLA
 NM_027009 replication factor C (activator 1) 3 (Rfc3), mRNA [NM_027009] KLA 1.71 1.88 2.23 1.86 1.17 1.37 .82
ATP .93 .90 1.00 .94 .72 .77 .68
KLA/ATP 1.74 1.98 2.39 2.16 1.50 1.24 .82
Rfc4
KLA  ATP  ATP+KLA
 NM_145480 replication factor C (activator 1) 4 (Rfc4), mRNA [NM_145480] KLA .39 .38 .36 .37 .31 .44 .35
ATP .97 .92 1.27 1.00 .55 .45 .32
KLA/ATP .39 .36 .50 .36 .33 .38 .24
Rfc5
KLA  ATP  ATP+KLA
 NM_028128 replication factor C (activator 1) 5 (Rfc5), mRNA [NM_028128] KLA .67 .65 .67 .61 .50 .52 .41
ATP .95 .90 1.04 1.05 .59 .34 .42
KLA/ATP .60 .60 .69 .64 .53 .45 .48
Rpa1
KLA  ATP  ATP+KLA
 NM_026653 replication protein A1 (Rpa1), mRNA [NM_026653] KLA .51 .51 .42 .36 .30 .42 .32
ATP 1.01 1.10 1.09 .92 .66 .38 .43
KLA/ATP .54 .49 .44 .41 .32 .30 .27
Rpa2
KLA  ATP  ATP+KLA
 D00812 mRNA for 30-kDa subunit of replication protein A, complete cds. [D00812] KLA .34 .36 .38 .32 .33 .42 .36
ATP 1.03 1.00 .91 .81 .43 .55 .27
KLA/ATP .39 .34 .39 .42 .35 .44 .27
Rpa2
KLA  ATP  ATP+KLA
 NM_011284 replication protein A2 (Rpa2), mRNA [NM_011284] KLA .34 .37 .38 .35 .36 .42 .36
ATP .98 .93 .87 .81 .47 .53 .26
KLA/ATP .36 .34 .40 .42 .36 .47 .24
Rpa3
KLA  ATP  ATP+KLA
 NM_026632 replication protein A3 (Rpa3), mRNA [NM_026632] KLA .54 .49 .54 .52 .46 .55 .48
ATP .89 .88 1.39 1.24 .56 .41 .39
KLA/ATP .48 .54 .77 .61 .41 .42 .32
Ssbp1
KLA  ATP  ATP+KLA
 NM_028358 single-stranded DNA binding protein 1 (Ssbp1), transcript variant 2, mRNA [NM_028358] KLA .85 .82 .84 .89 .78 .95 .97
ATP .79 .68 .85 .69 .77 1.24 .85
KLA/ATP .72 .71 .95 .72 .86 .94 .66
Ssbp1
KLA  ATP  ATP+KLA
 NM_212468 single-stranded DNA binding protein 1 (Ssbp1), transcript variant 1, mRNA [NM_212468] KLA .87 .89 .86 .81 .82 .89 .86
ATP .87 .84 .89 .78 .78 .77 .72
KLA/ATP .83 .79 .82 .71 .78 .75 .63