Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: African trypanosomiasis (mmu05143)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Apoa1
KLA  ATP  ATP+KLA
 NM_009692 apolipoprotein A-I (Apoa1), mRNA [NM_009692] KLA .99 1.00 1.00 1.02 1.01 1.02 .98
ATP 1.00 1.00 1.02 1.16 1.03 1.04 1.01
KLA/ATP 1.00 1.03 1.07 1.23 1.10 1.05 .98
EG629860
KLA  ATP  ATP+KLA
 M17953 gb|Mouse Ig rearranged H-chain V-region mRNA VJ1 [M17953] KLA .96 1.05 1.03 1.08 1.08 1.02 .98
ATP .97 .99 1.05 1.10 .95 .94 .91
KLA/ATP .96 .94 .97 1.04 .97 1.01 .89
F2rl1
KLA  ATP  ATP+KLA
 NM_007974 coagulation factor II (thrombin) receptor-like 1 (F2rl1), mRNA [NM_007974] KLA 1.03 1.05 1.00 .98 1.01 1.03 1.04
ATP 1.00 .99 1.03 1.09 1.03 1.04 1.09
KLA/ATP 1.07 1.02 .95 1.10 1.02 1.02 1.02
Fas
KLA  ATP  ATP+KLA
 AK086933 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030012O08 product:tumor necrosis factor receptor superfamily, member 6, full insert sequence. [AK086933] KLA 6.31 6.56 6.33 6.70 4.93 3.74 2.48
ATP .95 1.04 1.33 1.55 1.85 6.00 2.77
KLA/ATP 5.67 7.16 7.71 7.73 6.02 5.79 7.85
Fas
KLA  ATP  ATP+KLA
 NM_007987 Fas (TNF receptor superfamily member 6) (Fas), mRNA [NM_007987] KLA 17.08 17.45 19.08 17.38 13.33 6.78 4.46
ATP .98 .96 1.64 3.05 5.58 12.91 1.89
KLA/ATP 16.57 17.25 26.06 23.57 22.03 16.74 13.29
Fasl
KLA  ATP  ATP+KLA
 NM_010177 Fas ligand (TNF superfamily, member 6) (Fasl), mRNA [NM_010177] KLA 1.03 1.01 1.03 1.02 1.01 1.01 1.00
ATP 1.00 .99 1.04 1.21 1.18 1.20 1.01
KLA/ATP 1.00 1.02 1.07 1.16 1.18 1.23 1.00
Gnaq
KLA  ATP  ATP+KLA
 NM_008139 guanine nucleotide binding protein, alpha q polypeptide (Gnaq), mRNA [NM_008139] KLA .82 .82 .69 .64 .60 .55 .55
ATP 1.06 1.02 .87 .67 .50 .66 .57
KLA/ATP .82 .79 .66 .55 .41 .33 .48
Hba-a1
KLA  ATP  ATP+KLA
 NM_008218 hemoglobin alpha, adult chain 1 (Hba-a1), mRNA [NM_008218] KLA 1.02 1.05 1.06 1.01 1.04 1.02 1.01
ATP 1.00 1.04 1.10 1.05 .98 .99 1.06
KLA/ATP 1.02 .99 1.10 .98 .95 1.00 1.02
Hba-a2
KLA  ATP  ATP+KLA
 M10466 gb|Mouse alpha-globin mRNA. [M10466] KLA 1.16 1.09 1.19 1.12 1.19 1.24 1.21
ATP .96 1.00 1.07 1.05 .97 1.07 1.18
KLA/ATP 1.09 1.08 1.16 1.14 1.14 1.09 1.27
Hbb-b1
KLA  ATP  ATP+KLA
 NM_008220 hemoglobin, beta adult major chain (Hbb-b1), mRNA [NM_008220] KLA 1.11 1.11 1.10 1.11 1.07 1.09 .99
ATP 1.01 1.01 1.01 1.04 1.03 1.07 1.02
KLA/ATP 1.06 1.12 1.15 1.09 1.09 1.45 1.45
Icam1
KLA  ATP  ATP+KLA
 BC008626 intercellular adhesion molecule, mRNA (cDNA clone MGC:6195 IMAGE:3588949), complete cds [BC008626] KLA 36.67 32.93 28.63 27.91 14.65 8.16 4.15
ATP .96 .88 1.50 3.88 4.98 3.90 1.01
KLA/ATP 32.58 31.60 42.74 32.60 26.00 13.02 6.01
Icam1
KLA  ATP  ATP+KLA
 NM_010493 intercellular adhesion molecule 1 (Icam1), mRNA [NM_010493] KLA 15.66 15.20 12.96 12.31 9.39 6.17 3.81
ATP .96 1.06 1.21 4.19 4.33 3.16 1.06
KLA/ATP 14.31 15.46 17.84 17.60 13.77 8.36 5.42
Ifng
KLA  ATP  ATP+KLA
 NM_008337 interferon gamma (Ifng), mRNA [NM_008337] KLA 1.05 1.02 1.01 1.01 1.01 1.04 1.00
ATP 1.00 1.01 1.01 .98 .97 1.04 1.03
KLA/ATP 1.01 1.01 1.06 1.10 1.24 1.10 1.04
Igh-VJ55
8
KLA  ATP  ATP+KLA
 AY547436 immunoglobulin heavy chain VDJ region mRNA, partial cds [AY547436] KLA 1.06 1.05 1.01 .93 1.03 .96 .93
ATP .99 1.00 1.06 .95 .96 1.06 1.05
KLA/ATP .98 .94 1.07 .95 .97 .99 1.02
Igh-VJ55
8
KLA  ATP  ATP+KLA
 CA578712 gb|K0727F04-5N NIA Mouse Hematopoietic Stem Cell (Lin- [CA578712] KLA .99 .94 1.01 1.10 .93 .97 .92
ATP .93 1.04 1.01 .98 1.05 .96 .95
KLA/ATP .99 .95 .95 .98 1.02 .98 .95
Igh-VJ55
8
KLA  ATP  ATP+KLA
 ENSMUST00000103412 ens|Immunoglobulin heavy chain C gene segment [Source:IMGT/GENE_DB;Acc:IGHA] [ENSMUST00000103412] KLA 1.01 .97 1.20 1.01 .98 1.44 1.24
ATP .99 .98 1.07 1.03 1.00 1.01 1.21
KLA/ATP .99 1.02 .96 1.03 .97 1.13 1.30
Igh-VJ55
8
KLA  ATP  ATP+KLA
 ENSMUST00000103413 ens|Immunoglobulin heavy chain C gene segment [Source:IMGT/GENE_DB;Acc:IGHE] [ENSMUST00000103413] KLA 1.00 .99 1.06 1.06 .99 1.03 1.02
ATP 1.08 1.06 1.06 1.06 1.02 1.06 .95
KLA/ATP 1.00 1.04 1.09 1.02 1.06 1.02 .95
Igh-VJ55
8
KLA  ATP  ATP+KLA
 U39781 J558+ IgM heavy chain mRNA, hybridoma clone ME2B7, partial cds. [U39781] KLA .93 .89 .98 .97 1.03 1.00 .94
ATP 1.04 1.02 1.08 .94 .93 .90 .79
KLA/ATP .88 .89 .97 .93 .88 .92 .82
Il10
KLA  ATP  ATP+KLA
 NM_010548 interleukin 10 (Il10), mRNA [NM_010548] KLA 17.59 18.64 22.22 23.06 11.83 8.27 2.07
ATP 1.86 3.22 7.72 20.51 25.86 8.38 1.01
KLA/ATP 17.91 23.49 34.53 34.48 20.98 12.03 8.17
Il12a
KLA  ATP  ATP+KLA
 NM_008351 interleukin 12a (Il12a), mRNA [NM_008351] KLA 2.37 2.47 2.17 1.49 1.46 1.12 1.20
ATP 1.01 .97 1.12 1.07 1.02 1.07 1.06
KLA/ATP 2.01 2.76 2.54 1.70 1.08 1.10 1.27
Il12b
KLA  ATP  ATP+KLA
 NM_008352 interleukin 12b (Il12b), mRNA [NM_008352] KLA 194.79 211.32 198.97 173.01 142.24 40.28 3.10
ATP 1.05 1.10 1.59 1.99 2.71 2.72 1.52
KLA/ATP 191.27 223.23 280.10 224.29 183.03 68.43 10.69
Il18
KLA  ATP  ATP+KLA
 NM_008360 interleukin 18 (Il18), mRNA [NM_008360] KLA 12.14 11.96 12.28 12.96 12.23 7.84 2.40
ATP 1.06 .96 1.13 1.04 .92 1.67 2.29
KLA/ATP 11.55 11.63 13.03 9.98 9.08 6.50 6.72
Il1b
KLA  ATP  ATP+KLA
 NM_008361 interleukin 1 beta (Il1b), mRNA [NM_008361] KLA 149.78 133.59 100.91 116.58 86.48 89.37 64.72
ATP 3.49 13.96 61.44 70.91 82.12 162.79 28.18
KLA/ATP 130.32 139.00 219.12 148.17 165.44 172.57 146.98
Il6
KLA  ATP  ATP+KLA
 NM_031168 interleukin 6 (Il6), mRNA [NM_031168] KLA 352.99 378.70 276.81 168.47 59.99 18.66 8.27
ATP 1.04 1.08 2.28 3.69 30.40 161.93 2.11
KLA/ATP 334.28 528.66 ###.## 935.86 302.45 355.36 99.65
Indo
KLA  ATP  ATP+KLA
 NM_008324 indoleamine-pyrrole 2,3 dioxygenase (Indo), mRNA [NM_008324] KLA 1.56 1.62 1.87 1.73 1.52 1.38 1.28
ATP 1.09 1.01 1.08 1.02 1.00 1.06 1.07
KLA/ATP 1.53 1.60 1.78 1.50 1.49 1.40 3.38
Indol1
KLA  ATP  ATP+KLA
 NM_145949 indoleamine-pyrrole 2,3 dioxygenase-like 1 (Indol1), mRNA [NM_145949] KLA 2.01 2.13 2.31 2.13 2.14 2.14 2.52
ATP .96 .98 1.06 1.12 .99 1.18 1.25
KLA/ATP 2.03 2.15 1.83 1.54 1.38 1.32 2.07
Lama4
KLA  ATP  ATP+KLA
 NM_010681 laminin, alpha 4 (Lama4), mRNA [NM_010681] KLA .99 .99 1.01 1.02 .98 .97 .96
ATP 1.00 1.08 1.05 1.05 1.03 1.04 .96
KLA/ATP 1.00 1.03 .93 1.00 .94 .90 .95
Mm.19611
0
KLA  ATP  ATP+KLA
 145301548 Unknown KLA 1.11 1.20 1.32 1.25 1.20 1.28 1.23
ATP 1.08 1.11 1.22 1.29 1.08 1.13 1.01
KLA/ATP 1.20 1.19 1.40 1.17 1.24 1.18 1.11
Mm.25806
5
KLA  ATP  ATP+KLA
 148747407 Unknown KLA 1.05 1.02 1.03 1.00 .99 1.05 .94
ATP .98 .98 1.03 1.02 .99 1.06 1.03
KLA/ATP 1.01 1.02 1.03 1.01 .96 .98 1.01
Mm.26995
KLA  ATP  ATP+KLA
 141801686 Unknown KLA .97 .97 .91 .96 .93 .86 1.03
ATP 1.09 .99 .94 .98 .96 .82 .96
KLA/ATP .97 1.01 1.01 .92 .87 .84 .87
Mm.44160
1
KLA  ATP  ATP+KLA
 145966786 Unknown KLA 1.08 .94 1.01 .97 .79 .78 .71
ATP 1.09 .92 1.10 .75 .65 .92 .69
KLA/ATP 1.01 .92 1.16 .81 .69 .56 .63
Mm.44889
KLA  ATP  ATP+KLA
 157057165 Unknown KLA 1.20 1.25 1.45 1.49 1.63 1.70 1.66
ATP 1.00 1.03 1.03 1.00 1.12 1.06 1.23
KLA/ATP 1.25 1.15 1.16 1.16 1.15 1.41 1.71
Mm.5245
KLA  ATP  ATP+KLA
 118130193 Unknown KLA 1.62 1.58 1.58 1.32 1.15 1.18 1.17
ATP .95 .99 1.18 1.78 1.34 1.15 1.03
KLA/ATP 1.66 1.70 1.66 1.59 1.28 1.23 1.01
Mm.874
KLA  ATP  ATP+KLA
 6754317 Unknown KLA 24.98 24.87 26.43 39.61 12.88 8.64 1.63
ATP 1.97 3.50 11.05 28.47 38.30 10.44 .65
KLA/ATP 23.45 29.37 58.52 51.77 30.64 14.61 8.63
Myd88
KLA  ATP  ATP+KLA
 NM_010851 myeloid differentiation primary response gene 88 (Myd88), mRNA [NM_010851] KLA 3.35 3.51 3.91 4.13 4.13 3.62 2.53
ATP .99 .96 .79 .75 .93 2.15 1.60
KLA/ATP 3.37 3.52 3.52 3.48 2.81 3.03 3.33
Plcb1
KLA  ATP  ATP+KLA
 AK129166 mRNA for mKIAA0581 protein [AK129166] KLA 1.02 .98 .91 .91 .92 .95 .89
ATP 1.03 1.02 1.02 1.01 .90 1.02 1.04
KLA/ATP .98 .97 .91 .93 .92 1.01 1.16
Plcb1
KLA  ATP  ATP+KLA
 NM_019677 phospholipase C, beta 1 (Plcb1), mRNA [NM_019677] KLA .99 .94 .95 .97 .93 .92 .91
ATP 1.00 .96 .99 .95 .99 1.03 .98
KLA/ATP .93 .96 .94 .93 .87 1.00 1.06
Plcb2
KLA  ATP  ATP+KLA
 NM_177568 phospholipase C, beta 2 (Plcb2), mRNA [NM_177568] KLA .70 .68 .64 .67 .65 .76 .88
ATP .95 .94 1.04 .94 .72 .57 1.19
KLA/ATP .69 .68 .72 .63 .65 .55 .70
Plcb3
KLA  ATP  ATP+KLA
 NM_008874 phospholipase C, beta 3 (Plcb3), mRNA [NM_008874] KLA 1.72 1.78 1.82 1.65 1.67 1.44 1.21
ATP .97 1.04 .81 .87 .78 .88 .94
KLA/ATP 1.69 1.89 1.44 1.66 1.12 .73 .93
Plcb4
KLA  ATP  ATP+KLA
 AK082509 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230058B11 product:unclassifiable, full insert sequence. [AK082509] KLA 1.06 1.03 .97 .98 1.02 1.01 .99
ATP .99 1.07 1.09 .95 .97 .97 1.02
KLA/ATP .98 1.00 1.03 .96 1.02 .91 .98
Plcb4
KLA  ATP  ATP+KLA
 NM_013829 phospholipase C, beta 4 (Plcb4), mRNA [NM_013829] KLA .88 .94 .81 .82 .81 .86 1.01
ATP 1.00 1.01 .92 .93 .88 .85 .89
KLA/ATP .97 .94 .78 .80 .78 .86 .97
Prkca
KLA  ATP  ATP+KLA
 NM_011101 protein kinase C, alpha (Prkca), mRNA [NM_011101] KLA 1.00 .96 .94 .95 .95 .89 .96
ATP 1.00 1.03 .91 .94 .82 .87 1.13
KLA/ATP 1.02 .95 .91 .86 .78 .84 .94
Prkcb1
KLA  ATP  ATP+KLA
 NM_008855 protein kinase C, beta 1 (Prkcb1), mRNA [NM_008855] KLA .92 .95 .93 .78 .77 1.08 1.83
ATP 1.03 1.12 1.09 1.23 .90 2.08 .96
KLA/ATP .98 .99 .82 .89 .62 1.01 1.08
Prkcc
KLA  ATP  ATP+KLA
 NM_011102 protein kinase C, gamma (Prkcc), mRNA [NM_011102] KLA 1.02 1.04 1.11 1.04 .96 1.02 1.05
ATP .98 .98 1.05 1.03 1.08 .96 .95
KLA/ATP 1.21 1.16 1.09 1.07 1.04 .98 .93
Sele
KLA  ATP  ATP+KLA
 NM_011345 selectin, endothelial cell (Sele), mRNA [NM_011345] KLA 2.65 3.18 3.14 1.92 1.46 1.23 1.14
ATP .97 1.01 1.35 3.40 2.14 1.33 1.11
KLA/ATP 3.13 3.40 2.71 2.69 1.69 1.51 1.18
Thop1
KLA  ATP  ATP+KLA
 NM_022653 thimet oligopeptidase 1 (Thop1), mRNA [NM_022653] KLA .91 .95 .89 .76 .69 .59 .80
ATP 1.03 1.17 .91 1.22 .83 .65 .93
KLA/ATP .98 1.01 .70 .91 .59 .57 .48
Tlr9
KLA  ATP  ATP+KLA
 NM_031178 toll-like receptor 9 (Tlr9), mRNA [NM_031178] KLA 1.08 1.09 1.18 1.15 1.34 1.25 1.16
ATP 1.04 1.05 1.23 1.85 1.41 1.06 1.21
KLA/ATP 1.16 1.17 1.45 1.88 1.67 1.32 1.46
Tnf
KLA  ATP  ATP+KLA
 NM_013693 tumor necrosis factor (Tnf), mRNA [NM_013693] KLA 13.35 12.76 10.71 9.03 10.64 7.39 8.32
ATP 2.01 2.48 8.27 19.20 9.72 4.09 1.49
KLA/ATP 12.72 15.76 12.73 17.34 5.10 3.61 6.07
Vcam1
KLA  ATP  ATP+KLA
 NM_011693 vascular cell adhesion molecule 1 (Vcam1), mRNA [NM_011693] KLA 18.71 22.30 20.87 18.09 13.61 6.09 2.09
ATP 1.08 1.00 1.56 4.23 5.09 5.04 1.50
KLA/ATP 19.09 25.02 26.43 25.42 20.08 11.45 6.67