Gene/Proteome Database (LMPD)

LMPD ID
LMP000116
Gene ID
26424
Species
Mus musculus (Mouse)
Gene Name
nuclear receptor subfamily 5, group A, member 2
Gene Symbol
Nr5a2
Synonyms
AU020803; D1Ertd308e; Ftf; LRH-1; UF2-H3B
Alternate Names
nuclear receptor subfamily 5 group A member 2; liver receptor homolog 1; fetoprotein transcription factor
Chromosome
1
Map Location
1 E4|1 59.98 cM

Proteins

nuclear receptor subfamily 5 group A member 2 isoform 1
Refseq ID NP_109601
Protein GI 14010847
UniProt ID P45448
mRNA ID NM_030676
Length 560
RefSeq Status VALIDATED
MSASLDTGDFQEFLKHGLTAIASAPGSETRHSPKREEQLREKRAGLPDRHRRPIPARSRLVMLPKVETEAPGLVRSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNQKRYTCIENQNCQIDKTQRKRCPYCRFKKCIDVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTSAIQNIHSASKGLPLSHVALPPTDYDRSPFVTSPISMTMPPHSSLHGYQPYGHFPSRAIKSEYPDPYSSSPESMMGYSYMDGYQTNSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQSNRNRQEKLSAFGLLCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVAHGKEGTIFLVTGEHVDYSTIISHTEVAFNNLLSLAQELVVRLRSLQFDQREFVCLKFLVLFSSDVKNLENLQLVEGVQEQVNAALLDYTVCNYPQQTEKFGQLLLRLPEIRAISKQAEDYLYYKHVNGDVPYNNLLIEMLHAKRA
nuclear receptor subfamily 5 group A member 2 isoform 2
Refseq ID NP_001153241
Protein GI 229335598
UniProt ID Q1WLP7
mRNA ID NM_001159769
Length 499
RefSeq Status VALIDATED
MLPKVETEAPGLVRSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNQKRYTCIENQNCQIDKTQRKRCPYCRFKKCIDVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTSAIQNIHSASKGLPLSHVALPPTDYDRSPFVTSPISMTMPPHSSLHGYQPYGHFPSRAIKSEYPDPYSSSPESMMGYSYMDGYQTNSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQSNRNRQEKLSAFGLLCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVAHGKEGTIFLVTGEHVDYSTIISHTEVAFNNLLSLAQELVVRLRSLQFDQREFVCLKFLVLFSSDVKNLENLQLVEGVQEQVNAALLDYTVCNYPQQTEKFGQLLLRLPEIRAISKQAEDYLYYKHVNGDVPYNNLLIEMLHAKRA

Gene Information

Entrez Gene ID
26424
Gene Name
nuclear receptor subfamily 5, group A, member 2
Gene Symbol
Nr5a2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0005634 IDA:MGI C nucleus
GO:0003677 IDA:MGI F DNA binding
GO:0000978 IDA:NTNU_SB F RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA:NTNU_SB F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0005543 IEA:Ensembl F phospholipid binding
GO:0003700 ISS:UniProtKB F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0008206 IMP:MGI P bile acid metabolic process
GO:0042632 IMP:MGI P cholesterol homeostasis
GO:0031018 TAS:Reactome P endocrine pancreas development
GO:0045944 IDA:NTNU_SB P positive regulation of transcription from RNA polymerase II promoter
GO:0045070 IEA:Ensembl P positive regulation of viral genome replication
GO:0042127 IGI:MGI P regulation of cell proliferation
GO:0006355 ISS:UniProtKB P regulation of transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
mmu04950 Maturity onset diabetes of the young

REACTOME Pathway Links

REACTOME Pathway ID Description
5893581 Regulation of gene expression in early pancreatic precursor cells

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR016355 Steroidogenic_factor_1
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 5, group A, member 2
Protein Entry
Q1WLP7_MOUSE
UniProt ID
Q1WLP7
Species
Mouse

Comments

Comment Type Description
Function Binds to promoters containing the sequence element 5'- AACGACCGACCTTGAG-3'. Plays a role in the regulation of gene expression in liver and pancreas. May play a role in embryonic development (By similarity). {ECO:0000250}.
Similarity Belongs to the nuclear hormone receptor family. NR5 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus {ECO:0000305}.
Subunit Binds DNA as a monomer (By similarity). Interacts with GRIP1, NCOA2 and NR0B2. {ECO:0000250, ECO:0000269|PubMed:12820970, ECO:0000269|PubMed:15976031}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000116 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
14010847 RefSeq NP_109601 560 nuclear receptor subfamily 5 group A member 2 isoform 1
229335598 RefSeq NP_001153241 499 nuclear receptor subfamily 5 group A member 2 isoform 2

Identical Sequences to LMP000116 proteins

Reference Database Accession Length Protein Name
GI:14010847 GenBank AAA39447.1 560 liver receptor homologue [Mus musculus]
GI:14010847 GenBank AAE28147.1 560 Sequence 10 from patent US 5958697
GI:14010847 GenBank AAE82740.1 560 Sequence 10 from patent US 6297019
GI:229335598 GenBank AAZ99450.1 499 liver receptor-like protein 1 variant 2 [Mus musculus]
GI:14010847 GenBank AAI37846.1 560 Nuclear receptor subfamily 5, group A, member 2 [Mus musculus]
GI:229335598 RefSeq XP_006529685.1 499 PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X3 [Mus musculus]
GI:14010847 SwissProt P45448.3 560 RecName: Full=Nuclear receptor subfamily 5 group A member 2; AltName: Full=Liver receptor homolog 1; Short=LRH-1 [Mus musculus]

Related Sequences to LMP000116 proteins

Reference Database Accession Length Protein Name
GI:14010847 DBBJ BAA36339.1 560 FTZ-F1 beta1 [Rattus norvegicus]
GI:229335598 GenBank AAA39447.1 560 liver receptor homologue [Mus musculus]
GI:229335598 GenBank AAE28147.1 560 Sequence 10 from patent US 5958697
GI:229335598 GenBank AAE82740.1 560 Sequence 10 from patent US 6297019
GI:14010847 GenBank EDM09652.1 539 nuclear receptor subfamily 5, group A, member 2, isoform CRA_c [Rattus norvegicus]
GI:229335598 GenBank AAI37846.1 560 Nuclear receptor subfamily 5, group A, member 2 [Mus musculus]
GI:14010847 RefSeq NP_068510.1 560 nuclear receptor subfamily 5 group A member 2 [Rattus norvegicus]
GI:229335598 RefSeq NP_109601.1 560 nuclear receptor subfamily 5 group A member 2 isoform 1 [Mus musculus]
GI:14010847 RefSeq XP_006529683.1 552 PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X1 [Mus musculus]
GI:14010847 RefSeq XP_006529684.1 539 PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X2 [Mus musculus]
GI:229335598 SwissProt P45448.3 560 RecName: Full=Nuclear receptor subfamily 5 group A member 2; AltName: Full=Liver receptor homolog 1; Short=LRH-1 [Mus musculus]
GI:14010847 SwissProt Q9QWM1.1 560 RecName: Full=Nuclear receptor subfamily 5 group A member 2; AltName: Full=FTZ-F1 beta; AltName: Full=Liver receptor homolog 1; Short=LRH-1 [Rattus norvegicus]