Gene/Proteome Database (LMPD)

LMPD ID
LMP000142
Gene ID
23827
Species
Mus musculus (Mouse)
Gene Name
bisphosphate 3'-nucleotidase 1
Gene Symbol
Bpnt1
Synonyms
BPntase
Alternate Names
3'(2'),5'-bisphosphate nucleotidase 1;,PIP; PAP-inositol 1,4-phosphatase; PAP-inositol-1,4-phosphatase
Chromosome
1
Map Location
1|1 H4
EC Number
3.1.3.7

Proteins

3'(2'),5'-bisphosphate nucleotidase 1
Refseq ID NP_035924
Protein GI 39652626
UniProt ID Q9Z0S1
mRNA ID NM_011794
Length 308
RefSeq Status VALIDATED
MASSHTVLMRLVASAYSIAQKAGTIVRCVIAEGDLGIVQKTSATDLQTKADRLVQMSICSSLARKFPKLTIIGEEDLPPGEVDQELIEDGQWEEILKQPCPSQYSAIKEEDLVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGIINQPYYNYQAGPDAALGRTIWGVLGLGAFGFQLKEAPAGKHIITTTRSHSNQLVTDCISAMNPDTVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNALQYNKEVKHMNSAGVLAALRNYEYYASHVPESVKNALIP

Gene Information

Entrez Gene ID
23827
Gene Name
bisphosphate 3'-nucleotidase 1
Gene Symbol
Bpnt1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0008441 IDA:MGI F 3'(2'),5'-bisphosphate nucleotidase activity
GO:0004441 IEA:Ensembl F inositol-1,4-bisphosphate 1-phosphatase activity
GO:0000287 IEA:Ensembl F magnesium ion binding
GO:0016311 IDA:GOC P dephosphorylation
GO:0046854 IEA:InterPro P phosphatidylinositol phosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways
ko00920 Sulfur metabolism
mmu00920 Sulfur metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893224 Cytosolic sulfonation of small molecules

Domain Information

InterPro Annotations

Accession Description
IPR020550 Inositol monophosphatase, conserved site
IPR020583 Inositol monophosphatase, metal-binding site
IPR000760 Inositol_monophosphatase

UniProt Annotations

Entry Information

Gene Name
bisphosphate 3'-nucleotidase 1
Protein Entry
BPNT1_MOUSE
UniProt ID
Q9Z0S1
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme Regulation Uncompetitive inhibition by micromolar concentrations of lithium. Competitive inhibition by inositol 1,4- bisphosphate.
Function Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.
Similarity Belongs to the inositol monophosphatase family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000142 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
39652626 RefSeq NP_035924 308 3'(2'),5'-bisphosphate nucleotidase 1

Identical Sequences to LMP000142 proteins

Reference Database Accession Length Protein Name
GI:39652626 DBBJ BAB25850.1 308 unnamed protein product [Mus musculus]
GI:39652626 DBBJ BAE30807.1 308 unnamed protein product [Mus musculus]
GI:39652626 DBBJ BAE30872.1 308 unnamed protein product [Mus musculus]
GI:39652626 SwissProt Q9Z0S1.2 308 RecName: Full=3'(2'),5'-bisphosphate nucleotidase 1; AltName: Full=Bisphosphate 3'-nucleotidase 1; AltName: Full=PAP-inositol 1,4-phosphatase; Short=PIP [Mus musculus]

Related Sequences to LMP000142 proteins

Reference Database Accession Length Protein Name
GI:39652626 DBBJ BAE29926.1 308 unnamed protein product [Mus musculus]
GI:39652626 DBBJ BAE32585.1 308 unnamed protein product [Mus musculus]
GI:39652626 GenBank AAD17330.1 308 bisphosphate 3'-nucleotidase [Mus musculus]
GI:39652626 GenBank AAH11036.1 308 Bisphosphate 3'-nucleotidase 1 [Mus musculus]
GI:39652626 GenBank EDL13068.1 308 bisphosphate 3'-nucleotidase 1, isoform CRA_a [Mus musculus]
GI:39652626 GenBank EDL13070.1 308 bisphosphate 3'-nucleotidase 1, isoform CRA_a [Mus musculus]