Gene/Proteome Database (LMPD)

LMPD ID
LMP000255
Gene ID
64385
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 4, subfamily f, polypeptide 14
Gene Symbol
Cyp4f14
Synonyms
1300014O15Rik; cyp4f-14
Alternate Names
leukotriene-B4 omega-hydroxylase 3; cytochrome P450 4F14; cytochrome P450-LTB-omega; leukotriene-B4 20-monooxygenase 3; cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase)
Chromosome
17
Map Location
17 B1|17
EC Number
1.14.13.30

Proteins

leukotriene-B4 omega-hydroxylase 3
Refseq ID NP_071879
Protein GI 11967965
UniProt ID Q9EP75
mRNA ID NM_022434
Length 524
RefSeq Status VALIDATED
MSQLSLSWLGLGPEVAFPWKTLLLLGASWILARILIQIYAAYRNYRHLHGFPQPPKRNWLMGHVGMVTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYSILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLISDGSARLDMFEHVSLMTLDSLQKCVFSFDSNCQEKSSEYIAAILELSALVAKRHQQPLMFMDLLYNLTPDGMRFRKACNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRGREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVYDPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRAEGGLWLRVEPLSAGAH
leukotriene-B4 omega-hydroxylase 3
Refseq ID NP_001191262
Protein GI 324120982
UniProt ID Q9EP75
mRNA ID NM_001204333
Length 524
RefSeq Status VALIDATED
Protein sequence is identical to GI:11967965 (mRNA isoform)
leukotriene-B4 omega-hydroxylase 3
Refseq ID NP_001191265
Protein GI 324120989
UniProt ID Q9EP75
mRNA ID NM_001204336
Length 524
RefSeq Status VALIDATED
Protein sequence is identical to GI:11967965 (mRNA isoform)
leukotriene-B4 omega-hydroxylase 3
Refseq ID NP_001191263
Protein GI 324120985
UniProt ID Q9EP75
mRNA ID NM_001204334
Length 524
RefSeq Status VALIDATED
Protein sequence is identical to GI:11967965 (mRNA isoform)
leukotriene-B4 omega-hydroxylase 3
Refseq ID NP_001191264
Protein GI 324120987
UniProt ID Q9EP75
mRNA ID NM_001204335
Length 524
RefSeq Status VALIDATED
Protein sequence is identical to GI:11967965 (mRNA isoform)

Gene Information

Entrez Gene ID
64385
Gene Name
cytochrome P450, family 4, subfamily f, polypeptide 14
Gene Symbol
Cyp4f14
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0052871 IEA:UniProtKB-EC F alpha-tocopherol omega-hydroxylase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0050051 IEA:UniProtKB-EC F leukotriene-B4 20-monooxygenase activity

KEGG Pathway Links

KEGG Pathway ID Description
mmu00590 Arachidonic acid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893594 Miscellaneous substrates
5894066 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
5893593 Synthesis of Leukotrienes (LT) and Eoxins (EX)

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 4, subfamily f, polypeptide 14
Protein Entry
CP4FE_MOUSE
UniProt ID
Q9EP75
Species
Mouse

Comments

Comment Type Description
Catalytic Activity (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa- 6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)- 5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250|UniProtKB:P51869};
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH for the omega-hydroxylation of LTB4 (By similarity). {ECO:0000250}.
Pathway Lipid metabolism; leukotriene B4 degradation.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000255 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
11967965 RefSeq NP_071879 524 leukotriene-B4 omega-hydroxylase 3

Identical Sequences to LMP000255 proteins

Reference Database Accession Length Protein Name
GI:11967965 RefSeq NP_001191262.1 524 leukotriene-B4 omega-hydroxylase 3 [Mus musculus]
GI:11967965 RefSeq NP_001191263.1 524 leukotriene-B4 omega-hydroxylase 3 [Mus musculus]
GI:11967965 RefSeq NP_001191264.1 524 leukotriene-B4 omega-hydroxylase 3 [Mus musculus]
GI:11967965 RefSeq NP_001191265.1 524 leukotriene-B4 omega-hydroxylase 3 [Mus musculus]
GI:11967965 RefSeq XP_006524845.1 524 PREDICTED: leukotriene-B4 omega-hydroxylase 3 isoform X3 [Mus musculus]
GI:11967965 RefSeq XP_006524846.1 524 PREDICTED: leukotriene-B4 omega-hydroxylase 3 isoform X4 [Mus musculus]

Related Sequences to LMP000255 proteins

Reference Database Accession Length Protein Name
GI:11967965 GenBank EDL40284.1 532 cytochrome P450, family 4, subfamily f, polypeptide 14, isoform CRA_b [Mus musculus]
GI:11967965 RefSeq NP_062569.2 524 cytochrome P450 4F1 [Rattus norvegicus]
GI:11967965 RefSeq XP_006524843.1 532 PREDICTED: leukotriene-B4 omega-hydroxylase 3 isoform X1 [Mus musculus]
GI:11967965 RefSeq XP_006524844.1 531 PREDICTED: leukotriene-B4 omega-hydroxylase 3 isoform X2 [Mus musculus]
GI:11967965 RefSeq XP_008763402.1 524 PREDICTED: cytochrome P450 4F1 isoform X1 [Rattus norvegicus]
GI:11967965 RefSeq XP_008763403.1 524 PREDICTED: cytochrome P450 4F1 isoform X1 [Rattus norvegicus]