Gene/Proteome Database (LMPD)

LMPD ID
LMP000472
Gene ID
23760
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol transfer protein, beta
Gene Symbol
PITPNB
Synonyms
PI-TP-beta; PtdInsTP; VIB1B
Alternate Names
phosphatidylinositol transfer protein beta isoform; PtdIns transfer protein beta; phosphotidylinositol transfer protein, beta
Chromosome
22
Map Location
22q12.1
Summary
This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Orthologs
View orthologs and multiple alignments for PITPNB

Proteins

phosphatidylinositol transfer protein beta isoform isoform 1
Refseq ID NP_036531
Protein GI 6912594
UniProt ID P48739
mRNA ID NM_012399
Length 271
RefSeq Status REVIEWED
MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYEKDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANSPDCPQMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNFHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKRGSVRGTSAADV
phosphatidylinositol transfer protein beta isoform isoform 2
Refseq ID NP_001271206
Protein GI 546232151
UniProt ID P48739
mRNA ID NM_001284277
Length 272
RefSeq Status REVIEWED
MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYEKDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANSPDCPQMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNFHRQLFCWIDKWIDLTMEDIRRMEDETQKELETLRNQGQVRGTSAASDE
phosphatidylinositol transfer protein beta isoform isoform 3
Refseq ID NP_001271207
Protein GI 546232153
UniProt ID P48739
mRNA ID NM_001284278
Length 273
RefSeq Status REVIEWED
MGDLLMEKCRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYEKDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANSPDCPQMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNFHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKRGSVRGTSAADV

Gene Information

Entrez Gene ID
23760
Gene Name
phosphatidylinositol transfer protein, beta
Gene Symbol
PITPNB
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 TAS:Reactome C Golgi membrane
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0001701 IEA:Ensembl P in utero embryonic development
GO:0006629 NAS:ProtInc P lipid metabolic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0015914 TAS:Reactome P phospholipid transport
GO:0044281 TAS:Reactome P small molecule metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121401 Glycerophospholipid biosynthesis
REACT_121175 PI Metabolism
REACT_121079 PI and PC transport between ER and Golgi membranes
REACT_120870 Phospholipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR001666 Phosphatidylinositol transfer protein
IPR023393 START-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol transfer protein, beta
Protein Entry
PIPNB_HUMAN
UniProt ID
P48739
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P48739-1; Sequence=Displayed; Name=2; IsoId=P48739-2; Sequence=VSP_012762; Name=3; IsoId=P48739-3; Sequence=VSP_055132;
Function Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.
Ptm Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.
Similarity Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.
Subcellular Location Cytoplasm . Golgi apparatus .
Tissue Specificity Widely expressed in various tissues including brain.

Identical and Related Proteins

Unique RefSeq proteins for LMP000472 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6912594 RefSeq NP_036531 271 phosphatidylinositol transfer protein beta isoform isoform 1
546232151 RefSeq NP_001271206 272 phosphatidylinositol transfer protein beta isoform isoform 2
546232153 RefSeq NP_001271207 273 phosphatidylinositol transfer protein beta isoform isoform 3

Identical Sequences to LMP000472 proteins

Reference Database Accession Length Protein Name
GI:546232153 DBBJ BAH13686.1 273 unnamed protein product [Homo sapiens]
GI:546232153 GenBank EAW59743.1 273 phosphatidylinositol transfer protein, beta, isoform CRA_a [Homo sapiens]
GI:6912594 GenBank AIC51030.1 271 PITPNB, partial [synthetic construct]
GI:546232151 GenBank AIC59886.1 272 PITPNB, partial [synthetic construct]
GI:546232151 RefSeq XP_003820225.1 272 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X1 [Pan paniscus]
GI:546232151 RefSeq XP_003905411.1 272 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X1 [Papio anubis]
GI:6912594 RefSeq XP_004063264.1 271 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform 1 [Gorilla gorilla gorilla]
GI:546232151 RefSeq XP_004063265.1 272 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform 2 [Gorilla gorilla gorilla]
GI:546232153 RefSeq XP_004063266.1 273 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform 3 [Gorilla gorilla gorilla]
GI:546232151 RefSeq XP_005567764.1 272 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X1 [Macaca fascicularis]
GI:6912594 RefSeq XP_005567766.1 271 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X3 [Macaca fascicularis]
GI:546232151 RefSeq XP_007973449.1 272 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X1 [Chlorocebus sabaeus]
GI:6912594 RefSeq XP_007973450.1 271 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X2 [Chlorocebus sabaeus]
GI:6912594 RefSeq XP_009232489.1 271 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X1 [Pongo abelii]
GI:6912594 RefSeq XP_010373875.1 271 PREDICTED: phosphatidylinositol transfer protein beta isoform [Rhinopithecus roxellana]

Related Sequences to LMP000472 proteins

Reference Database Accession Length Protein Name
GI:546232153 EMBL CAK54572.1 271 PITPNB [synthetic construct]
GI:546232153 EMBL CAK54871.1 271 PITPNB, partial [synthetic construct]
GI:6912594 GenBank JAA44206.1 283 phosphatidylinositol transfer protein, beta [Pan troglodytes]
GI:6912594 GenBank JAA44207.1 283 phosphatidylinositol transfer protein, beta [Pan troglodytes]
GI:546232153 RefSeq XP_515049.1 271 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X2 [Pan troglodytes]
GI:6912594 RefSeq XP_001927816.1 271 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X1 [Sus scrofa]
GI:546232151 RefSeq XP_002926313.1 272 PREDICTED: phosphatidylinositol transfer protein beta isoform-like [Ailuropoda melanoleuca]
GI:546232153 RefSeq XP_003258078.1 271 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform 1 [Nomascus leucogenys]
GI:546232153 RefSeq XP_003258080.1 273 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform 3 [Nomascus leucogenys]
GI:6912594 RefSeq XP_003938529.1 271 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X2 [Saimiri boliviensis boliviensis]
GI:546232151 RefSeq XP_004816030.1 272 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X1 [Mustela putorius furo]
GI:546232151 RefSeq XP_005636443.1 272 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X3 [Canis lupus familiaris]
GI:546232151 RefSeq XP_005657393.1 272 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X2 [Sus scrofa]
GI:546232151 RefSeq XP_006067733.1 272 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X1 [Bubalus bubalis]
GI:6912594 RefSeq XP_006067734.1 271 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X2 [Bubalus bubalis]
GI:546232151 RefSeq XP_008568171.1 272 PREDICTED: phosphatidylinositol transfer protein beta isoform isoform X1 [Galeopterus variegatus]
GI:546232153 SwissProt P48739.2 271 RecName: Full=Phosphatidylinositol transfer protein beta isoform; Short=PI-TP-beta; Short=PtdIns transfer protein beta; Short=PtdInsTP beta [Homo sapiens]
GI:6912594 SwissProt Q9TR36.3 271 RecName: Full=Phosphatidylinositol transfer protein beta isoform; Short=PI-TP-beta; Short=PtdIns transfer protein beta; Short=PtdInsTP beta; AltName: Full=Phosphatidylinositol-transfer protein 36 kDa isoform; Short=PI-TP 36 kda isoform [Bos taurus]