Gene/Proteome Database (LMPD)

LMPD ID
LMP000483
Gene ID
218772
Species
Mus musculus (Mouse)
Gene Name
retinoic acid receptor, beta
Gene Symbol
Rarb
Synonyms
A830025K23; Hap; Nr1b2
Alternate Names
retinoic acid receptor beta; RAR-beta; nuclear receptor subfamily 1 group B member 2
Chromosome
14
Map Location
14 A1-A3|14 7.08 cM

Proteins

retinoic acid receptor beta isoform beta1
Refseq ID NP_001276690
Protein GI 576795787
UniProt ID P22605
mRNA ID NM_001289761
Length 455
RefSeq Status VALIDATED
MSTSSHACPVPAVRGHMTHYPAAPYPLLFPPVIRGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNIAEHSPSVSPSSVENSGVSQSPLLQ
retinoic acid receptor beta isoform beta2
Refseq ID NP_035373
Protein GI 45593124
UniProt ID P22605
mRNA ID NM_011243
Length 448
RefSeq Status VALIDATED
MFDCMDVLSVSPGQILDFYTASPSSCMLQEKALKACLSGFTQAEWQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNIAEHSPSVSPSSVENSGVSQSPLLQ
retinoic acid receptor beta isoform beta3
Refseq ID NP_001276689
Protein GI 576795732
UniProt ID P22605
mRNA ID NM_001289760
Length 482
RefSeq Status VALIDATED
MSTSSHACPVPAVRGHMTHYPAAPYPLLFPPVIRGLSLPPLHGLHGHPPPSGCSTPSPASVGQACQRTTGGSQFAASTKWTPSLNAAIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNIAEHSPSVSPSSVENSGVSQSPLLQ
retinoic acid receptor beta isoform beta4
Refseq ID NP_001276691
Protein GI 576796321
UniProt ID P22605
mRNA ID NM_001289762
Length 399
RefSeq Status VALIDATED
MENAIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNIAEHSPSVSPSSVENSGVSQSPLLQ

Gene Information

Entrez Gene ID
218772
Gene Name
retinoic acid receptor, beta
Gene Symbol
Rarb
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0000977 IDA:MGI F RNA polymerase II regulatory region sequence-specific DNA binding
GO:0008144 IEA:Ensembl F drug binding
GO:0003708 IEA:InterPro F retinoic acid receptor activity
GO:0043565 IDA:MGI F sequence-specific DNA binding
GO:0003700 IDA:MGI F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0060348 IGI:MGI P bone development
GO:0048566 IEA:Ensembl P embryonic digestive tract development
GO:0048048 IGI:MGI P embryonic eye morphogenesis
GO:0035116 IGI:MGI P embryonic hindlimb morphogenesis
GO:0002068 IGI:MGI P glandular epithelial cell development
GO:0003417 IGI:MGI P growth plate cartilage development
GO:0035264 IGI:MGI P multicellular organism growth
GO:0043066 IGI:MGI P negative regulation of apoptotic process
GO:0061037 IMP:MGI P negative regulation of cartilage development
GO:0008285 IGI:MGI P negative regulation of cell proliferation
GO:0032331 IMP:MGI P negative regulation of chondrocyte differentiation
GO:0000122 IDA:MGI P negative regulation of transcription from RNA polymerase II promoter
GO:0022008 IMP:MGI P neurogenesis
GO:0003148 IGI:MGI P outflow tract septum morphogenesis
GO:0043065 IGI:MGI P positive regulation of apoptotic process
GO:0008284 IGI:MGI P positive regulation of cell proliferation
GO:0045666 IEA:Ensembl P positive regulation of neuron differentiation
GO:0043068 IGI:MGI P positive regulation of programmed cell death
GO:0045944 IDA:MGI P positive regulation of transcription from RNA polymerase II promoter
GO:0031641 IEA:Ensembl P regulation of myelination
GO:0060041 IGI:MGI P retina development in camera-type eye
GO:0003406 IGI:MGI P retinal pigment epithelium development
GO:0021756 IMP:MGI P striatum development
GO:0001657 IMP:MGI P ureteric bud development
GO:0055012 IMP:MGI P ventricular cardiac muscle cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
mmu05223 Non-small cell lung cancer
mmu05222 Small cell lung cancer

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR003078 Retinoic acid receptor
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
retinoic acid receptor, beta
Protein Entry
RARB_MOUSE
UniProt ID
P22605
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=Beta-3; IsoId=P22605-1; Sequence=Displayed; Name=Beta-1; IsoId=P22605-2; Sequence=VSP_003639, VSP_003640; Name=Beta-2; IsoId=P22605-3; Sequence=VSP_003636; Name=Beta-4; IsoId=P22605-4; Sequence=VSP_003637, VSP_003638;
Disruption Phenotype Rarb and Rarg, but not Rarb and Rara, double null mice exhibit growth retardation 3 weeks after birth. Defects are found in the growth plates with deficiency in cartilage. Growth retardation was noticable in limb sketal elements such as femurs. Early lethality and male sterility due to squamous metaplasia of the seminal vesicles and prostate are also observed. Isoform 2 mutants appear normal. {ECO:0000269|PubMed:19389355}.
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. {ECO:0000250, ECO:0000269|PubMed:19389355}.
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus.
Subunit Homodimer (By similarity). Heterodimer; with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Interacts weakly with NCOR2 (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000483 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
576795787 RefSeq NP_001276690 455 retinoic acid receptor beta isoform beta1
45593124 RefSeq NP_035373 448 retinoic acid receptor beta isoform beta2
576795732 RefSeq NP_001276689 482 retinoic acid receptor beta isoform beta3
576796321 RefSeq NP_001276691 399 retinoic acid receptor beta isoform beta4

Identical Sequences to LMP000483 proteins

Reference Database Accession Length Protein Name
GI:45593124 GenBank AAB25784.2 448 retinoic acid nuclear receptor isoform beta 2 [Mus sp.]
GI:45593124 GenBank AAH76597.1 448 Retinoic acid receptor, beta [Mus musculus]
GI:45593124 GenBank EDL20643.1 448 retinoic acid receptor, beta, isoform CRA_a [Mus musculus]
GI:45593124 PRF - 448 retinoic acid receptor beta [Mus musculus]
GI:576795787 RefSeq XP_006518070.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Mus musculus]
GI:576795732 SwissProt P22605.1 482 RecName: Full=Retinoic acid receptor beta; Short=RAR-beta; AltName: Full=Nuclear receptor subfamily 1 group B member 2 [Mus musculus]

Related Sequences to LMP000483 proteins

Reference Database Accession Length Protein Name
GI:45593124 GenBank AAL02361.1 448 retinoic acid receptor beta-2 [Mesocricetus auratus]
GI:576796321 GenBank EDL20643.1 448 retinoic acid receptor, beta, isoform CRA_a [Mus musculus]
GI:45593124 GenBank EDL94092.1 448 retinoic acid receptor, beta [Rattus norvegicus]
GI:576796321 PRF - 448 retinoic acid receptor beta [Mus musculus]
GI:576796321 RefSeq NP_035373.1 448 retinoic acid receptor beta isoform beta2 [Mus musculus]
GI:576795787 RefSeq XP_002716265.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Oryctolagus cuniculus]
GI:576795787 RefSeq XP_002926489.1 455 PREDICTED: retinoic acid receptor beta-like isoform 1 [Ailuropoda melanoleuca]
GI:576795787 RefSeq XP_003433175.1 455 PREDICTED: retinoic acid receptor beta isoform X3 [Canis lupus familiaris]
GI:45593124 RefSeq XP_003499232.1 448 PREDICTED: retinoic acid receptor beta isoform X3 [Cricetulus griseus]
GI:576795787 RefSeq XP_003499233.1 455 PREDICTED: retinoic acid receptor beta isoform X2 [Cricetulus griseus]
GI:45593124 RefSeq NP_113717.1 448 retinoic acid receptor beta [Rattus norvegicus]
GI:45593124 RefSeq NP_001268285.1 448 retinoic acid receptor, beta [Mesocricetus auratus]
GI:45593124 RefSeq XP_005348613.1 448 PREDICTED: retinoic acid receptor beta [Microtus ochrogaster]
GI:576795732 RefSeq XP_006176357.1 482 PREDICTED: retinoic acid receptor beta isoform X1 [Camelus ferus]
GI:576795732 RefSeq XP_006518070.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Mus musculus]
GI:576796321 RefSeq NP_001276689.1 482 retinoic acid receptor beta isoform beta3 [Mus musculus]
GI:576795732 RefSeq XP_006883412.1 482 PREDICTED: retinoic acid receptor beta isoform X3 [Elephantulus edwardii]
GI:576795732 RefSeq XP_006851683.1 482 PREDICTED: retinoic acid receptor beta isoform X3 [Chrysochloris asiatica]
GI:576795787 RefSeq XP_006936526.1 455 PREDICTED: retinoic acid receptor beta isoform X2 [Felis catus]
GI:576796321 RefSeq NP_001277195.1 399 retinoic acid receptor beta isoform 4 [Homo sapiens]
GI:576795732 RefSeq XP_007517174.1 482 PREDICTED: retinoic acid receptor beta isoform X1 [Erinaceus europaeus]
GI:576795732 RefSeq XP_007934557.1 482 PREDICTED: retinoic acid receptor beta isoform X1 [Orycteropus afer afer]
GI:576795787 RefSeq XP_008516546.1 455 PREDICTED: retinoic acid receptor beta isoform X1 [Equus przewalskii]
GI:576796321 SwissProt P22605.1 482 RecName: Full=Retinoic acid receptor beta; Short=RAR-beta; AltName: Full=Nuclear receptor subfamily 1 group B member 2 [Mus musculus]