Gene/Proteome Database (LMPD)

LMPD ID
LMP000567
Gene ID
1592
Species
Homo sapiens (Human)
Gene Name
cytochrome P450, family 26, subfamily A, polypeptide 1
Gene Symbol
CYP26A1
Synonyms
CP26; CYP26; P450RAI; P450RAI1
Alternate Names
cytochrome P450 26A1; hP450RAI; cytochrome P450RAI; retinoic acid 4-hydroxylase; P450, retinoic acid-inactivating, 1; retinoic acid-metabolizing cytochrome; cytochrome P450 retinoic acid-inactivating 1; cytochrome P450, subfamily XXVIA, polypeptide 1
Chromosome
10
Map Location
10q23-q24
EC Number
1.14.-.-
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for CYP26A1

Proteins

cytochrome P450 26A1 isoform 1
Refseq ID NP_000774
Protein GI 16933530
UniProt ID O43174
mRNA ID NM_000783
Length 497
RefSeq Status REVIEWED
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI
cytochrome P450 26A1 isoform 2
Refseq ID NP_476498
Protein GI 16933528
UniProt ID O43174
mRNA ID NM_057157
Length 428
RefSeq Status REVIEWED
MKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI

Gene Information

Entrez Gene ID
1592
Gene Name
cytochrome P450, family 26, subfamily A, polypeptide 1
Gene Symbol
CYP26A1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0020037 NAS:BHF-UCL F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0019825 TAS:ProtInc F oxygen binding
GO:0008401 IDA:BHF-UCL F retinoic acid 4-hydroxylase activity
GO:0001972 IDA:BHF-UCL F retinoic acid binding
GO:0009952 IEA:Ensembl P anterior/posterior pattern specification
GO:0071300 IEA:Ensembl P cellular response to retinoic acid
GO:0007417 IEA:Ensembl P central nervous system development
GO:0008152 TAS:ProtInc P metabolic process
GO:0048387 TAS:BHF-UCL P negative regulation of retinoic acid receptor signaling pathway
GO:0014032 IEA:Ensembl P neural crest cell development
GO:0034653 IDA:BHF-UCL P retinoic acid catabolic process
GO:0048384 IEA:Ensembl P retinoic acid receptor signaling pathway
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006766 TAS:Reactome P vitamin metabolic process
GO:0006805 TAS:Reactome P xenobiotic metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 26, subfamily A, polypeptide 1
Protein Entry
CP26A_HUMAN
UniProt ID
O43174
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43174-1; Sequence=Displayed; Name=2; IsoId=O43174-2; Sequence=VSP_045087; Note=No experimental confirmation available.;
Cofactor Name=heme; Xref=ChEBI
Function Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
Induction By retinoic acid.
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain.

Identical and Related Proteins

Unique RefSeq proteins for LMP000567 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16933530 RefSeq NP_000774 497 cytochrome P450 26A1 isoform 1
16933528 RefSeq NP_476498 428 cytochrome P450 26A1 isoform 2

Identical Sequences to LMP000567 proteins

Reference Database Accession Length Protein Name
GI:16933528 GenBank EAW50078.1 428 cytochrome P450, family 26, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens]
GI:16933530 GenBank EAW50079.1 497 cytochrome P450, family 26, subfamily A, polypeptide 1, isoform CRA_b [Homo sapiens]
GI:16933530 GenBank AAI57064.1 497 Cytochrome P450, family 26, subfamily A, polypeptide 1 [synthetic construct]
GI:16933530 GenBank AAI56284.1 497 Cytochrome P450, family 26, subfamily A, polypeptide 1, partial [synthetic construct]
GI:16933530 GenBank AHE01160.1 497 Sequence 56076 from patent US 8586006
GI:16933528 GenBank AHE01161.1 428 Sequence 56077 from patent US 8586006
GI:16933530 SwissProt O43174.2 497 RecName: Full=Cytochrome P450 26A1; AltName: Full=Cytochrome P450 retinoic acid-inactivating 1; Short=Cytochrome P450RAI; Short=hP450RAI; AltName: Full=Retinoic acid 4-hydroxylase; AltName: Full=Retinoic acid-metabolizing cytochrome [Homo sapiens]

Related Sequences to LMP000567 proteins

Reference Database Accession Length Protein Name
GI:16933528 GenBank EAW50079.1 497 cytochrome P450, family 26, subfamily A, polypeptide 1, isoform CRA_b [Homo sapiens]
GI:16933528 GenBank AAI57064.1 497 Cytochrome P450, family 26, subfamily A, polypeptide 1 [synthetic construct]
GI:16933528 GenBank AAI56284.1 497 Cytochrome P450, family 26, subfamily A, polypeptide 1, partial [synthetic construct]
GI:16933528 GenBank AHE01160.1 497 Sequence 56076 from patent US 8586006
GI:16933528 RefSeq NP_000774.2 497 cytochrome P450 26A1 isoform 1 [Homo sapiens]
GI:16933530 RefSeq XP_001147866.1 497 PREDICTED: cytochrome P450 26A1 [Pan troglodytes]
GI:16933530 RefSeq XP_002821026.1 497 PREDICTED: cytochrome P450 26A1 isoform X1 [Pongo abelii]
GI:16933530 RefSeq NP_001180844.1 497 cytochrome P450 26A1 [Macaca mulatta]
GI:16933530 RefSeq XP_004049845.1 497 PREDICTED: cytochrome P450 26A1-like isoform 1 [Gorilla gorilla gorilla]
GI:16933530 RefSeq XP_005566019.1 497 PREDICTED: cytochrome P450 26A1-like [Macaca fascicularis]
GI:16933530 RefSeq XP_008948940.1 497 PREDICTED: LOW QUALITY PROTEIN: cytochrome P450 26A1 [Pan paniscus]
GI:16933528 SwissProt O43174.2 497 RecName: Full=Cytochrome P450 26A1; AltName: Full=Cytochrome P450 retinoic acid-inactivating 1; Short=Cytochrome P450RAI; Short=hP450RAI; AltName: Full=Retinoic acid 4-hydroxylase; AltName: Full=Retinoic acid-metabolizing cytochrome [Homo sapiens]