Gene/Proteome Database (LMPD)

LMPD ID
LMP000574
Gene ID
8879
Species
Homo sapiens (Human)
Gene Name
sphingosine-1-phosphate lyase 1
Gene Symbol
SGPL1
Synonyms
S1PL; SPL
Alternate Names
sphingosine-1-phosphate lyase 1; hSPL; SPL 1; SP-lyase 1; sphingosine-1-phosphate aldolase
Chromosome
10
Map Location
10q21
EC Number
4.1.2.27

Proteins

sphingosine-1-phosphate lyase 1
Refseq ID NP_003892
Protein GI 31982936
UniProt ID O95470
mRNA ID NM_003901
Length 568
RefSeq Status VALIDATED
MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFVFQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGSPKPH

Gene Information

Entrez Gene ID
8879
Gene Name
sphingosine-1-phosphate lyase 1
Gene Symbol
SGPL1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:UniProtKB C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0030176 NAS:UniProtKB C integral component of endoplasmic reticulum membrane
GO:0016831 IEA:InterPro F carboxy-lyase activity
GO:0030170 IEA:InterPro F pyridoxal phosphate binding
GO:0008117 IDA:UniProtKB F sphinganine-1-phosphate aldolase activity
GO:0033327 IEA:Ensembl P Leydig cell differentiation
GO:0008209 IEA:Ensembl P androgen metabolic process
GO:0097190 IDA:UniProtKB P apoptotic signaling pathway
GO:0006672 IDA:UniProtKB P ceramide metabolic process
GO:0008210 IEA:Ensembl P estrogen metabolic process
GO:0060325 IEA:Ensembl P face morphogenesis
GO:0006631 IDA:UniProtKB P fatty acid metabolic process
GO:0010761 IEA:Ensembl P fibroblast migration
GO:0030097 IEA:Ensembl P hemopoiesis
GO:0001822 IEA:Ensembl P kidney development
GO:0001553 IEA:Ensembl P luteinization
GO:0060021 IEA:Ensembl P palate development
GO:0048008 IEA:Ensembl P platelet-derived growth factor receptor signaling pathway
GO:0009791 IEA:Ensembl P post-embryonic development
GO:0040014 IEA:Ensembl P regulation of multicellular organism growth
GO:0048705 IEA:Ensembl P skeletal system morphogenesis
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0007283 IEA:Ensembl P spermatogenesis
GO:0030148 TAS:Reactome P sphingolipid biosynthetic process
GO:0030149 IDA:UniProtKB P sphingolipid catabolic process
GO:0006665 TAS:Reactome P sphingolipid metabolic process
GO:0001570 IEA:Ensembl P vasculogenesis

KEGG Pathway Links

KEGG Pathway ID Description
hsa00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_115810 Sphingolipid de novo biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002129 Pyridoxal phosphate-dependent decarboxylase
IPR015424 Pyridoxal phosphate-dependent transferase
IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1

UniProt Annotations

Entry Information

Gene Name
sphingosine-1-phosphate lyase 1
Protein Entry
SGPL1_HUMAN
UniProt ID
O95470
Species
Human

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=5.2 uM for sphingosine 1-phosphate ;
Catalytic Activity Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. {ECO
Cofactor Name=pyridoxal 5'-phosphate; Xref=ChEBI
Function Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. {ECO
Interaction Q86WV6:TMEM173; NbExp=2; IntAct=EBI-1046170, EBI-2800345;
Pathway Lipid metabolism; sphingolipid metabolism.
Sequence Caution Sequence=BAA86566.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.
Subcellular Location Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Subunit Homodimer.
Tissue Specificity Found in liver and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP000574 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31982936 RefSeq NP_003892 568 sphingosine-1-phosphate lyase 1

Identical Sequences to LMP000574 proteins

Reference Database Accession Length Protein Name
GI:31982936 GenBank ACP87642.1 568 Sequence 2 from patent US 7504225
GI:31982936 GenBank ADF21398.1 568 Sequence 18 from patent US 7674580
GI:31982936 GenBank AEK15394.1 568 Sequence 18 from patent US 7973143
GI:31982936 GenBank AFD38198.1 568 Sequence 8 from patent US 8124111
GI:31982936 GenBank AIC55492.1 568 SGPL1, partial [synthetic construct]
GI:31982936 RefSeq XP_005270320.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X1 [Homo sapiens]

Related Sequences to LMP000574 proteins

Reference Database Accession Length Protein Name
GI:31982936 DBBJ BAA86566.1 580 KIAA1252 protein, partial [Homo sapiens]
GI:31982936 GenBank ACM82388.1 580 Sequence 7886 from patent US 6812339
GI:31982936 RefSeq XP_001171432.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X2 [Pan troglodytes]
GI:31982936 RefSeq XP_009456914.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X2 [Pan troglodytes]
GI:31982936 RefSeq XP_009456915.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X2 [Pan troglodytes]
GI:31982936 RefSeq XP_010361157.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 [Rhinopithecus roxellana]