Gene/Proteome Database (LMPD)

LMPD ID
LMP000578
Gene ID
19
Species
Homo sapiens (Human)
Gene Name
ATP-binding cassette, sub-family A (ABC1), member 1
Gene Symbol
ABCA1
Synonyms
ABC-1; ABC1; CERP; HDLDT1; TGD
Chromosome
9
Map Location
9q31.1
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ABCA1

Proteins

ATP-binding cassette sub-family A member 1
Refseq ID NP_005493
Protein GI 21536376
UniProt ID O95477
mRNA ID NM_005502
Length 2261
RefSeq Status REVIEWED
MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDTSMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILHKVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPILRTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGSVYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVFTGITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV

Gene Information

Entrez Gene ID
19
Gene Name
ATP-binding cassette, sub-family A (ABC1), member 1
Gene Symbol
ABCA1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0016887 IEA:InterPro F ATPase activity

KEGG Pathway Links

KEGG Pathway ID Description
hsa02010 ABC transporters
hsa04975 Fat digestion and absorption

Domain Information

InterPro Annotations

Accession Description
IPR003593 AAA+ ATPase domain
IPR026082 ABC transporter A, ABCA
IPR017871 ABC transporter, conserved site
IPR003439 ABC_transporter-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
ATP-binding cassette, sub-family A (ABC1), member 1
Protein Entry
ABCA1_HUMAN
UniProt ID
O95477
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP000578 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21536376 RefSeq NP_005493 2261 ATP-binding cassette sub-family A member 1

Identical Sequences to LMP000578 proteins

Reference Database Accession Length Protein Name
GI:21536376 GenBank ACM96429.1 2261 Sequence 10 from patent US 7470659
GI:21536376 GenBank ACM96437.1 2261 Sequence 9 from patent US 7470660
GI:21536376 GenBank ACM96438.1 2261 Sequence 10 from patent US 7470660
GI:21536376 GenBank AFO05670.1 2261 Sequence 308 from patent US 8216786
GI:21536376 GenBank AHD76079.1 2261 Sequence 19352 from patent US 8586006
GI:21536376 SwissProt O95477.3 2261 RecName: Full=ATP-binding cassette sub-family A member 1; AltName: Full=ATP-binding cassette transporter 1; Short=ABC-1; Short=ATP-binding cassette 1; AltName: Full=Cholesterol efflux regulatory protein [Homo sapiens]

Related Sequences to LMP000578 proteins

Reference Database Accession Length Protein Name
GI:21536376 GenBank EAW58994.1 2261 ATP-binding cassette, sub-family A (ABC1), member 1, isoform CRA_c [Homo sapiens]
GI:21536376 GenBank ADA18451.1 2261 Sequence 275 from patent US 7608413
GI:21536376 GenBank ADS30494.1 2261 Sequence 1026 from patent US 7781168
GI:21536376 GenBank ADS46335.1 2261 Sequence 77 from patent US 7799530
GI:21536376 GenBank AEN34347.1 2261 Sequence 275 from patent US 7998689
GI:21536376 GenBank AEU56995.1 2261 Sequence 1 from patent US 8067219