Gene/Proteome Database (LMPD)

LMPD ID
LMP000594
Gene ID
9562
Species
Homo sapiens (Human)
Gene Name
multiple inositol-polyphosphate phosphatase 1
Gene Symbol
MINPP1
Synonyms
HIPER1; MINPP2; MIPP
Alternate Names
multiple inositol polyphosphate phosphatase 1; 2,3-BPG phosphatase; ins(1,3,4,5)P(4) 3-phosphatase; 2,3-bisphosphoglycerate 3-phosphatase; multiple inositol polyphosphate phosphatase 2; inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; multiple inositol polyphosphate histidine phosphatase, 1
Chromosome
10
Map Location
10q23
EC Number
3.1.3.62
Summary
This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]
Orthologs
View orthologs and multiple alignments for MINPP1

Proteins

multiple inositol polyphosphate phosphatase 1 isoform 1 precursor
Refseq ID NP_004888
Protein GI 19923761
UniProt ID Q9UNW1
mRNA ID NM_004897
Length 487
RefSeq Status VALIDATED
MLRAPGCLLRTSVAPAAALAAALLSSLARCSLLEPRDPVASSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCTPVQLVALIRHGTRYPTVKQIRKLRQLHGLLQARGSRDGGASSTGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQGLWQHYHPGLPPPDVADMEFGPPTVNDKLMRFFDHCEKFLTEVEKNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNADLIQVAFFTCSFDLAIKGVKSPWCDVFDIDDAKVLEYLNDLKQYWKRGYGYTINSRSSCTLFQDIFQHLDKAVEQKQRSQPISSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNYKKQMHRKFRSGLIVPYASNLIFVLYHCENAKTPKEQFRVQMLLNEKVLPLAYSQETVSFYEDLKNHYKDILQSCQTSEECELARANSTSDEL
sig_peptide: 1..30 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2969 peptide sequence: MLRAPGCLLRTSVAPAAALAAALLSSLARC sig_peptide: 1..30 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2969 peptide sequence: MLRAPGCLLRTSVAPAAALAAALLSSLARC mat_peptide: 31..487 product: Multiple inositol polyphosphate phosphatase 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9UNW1.1) calculated_mol_wt: 52101 peptide sequence: SLLEPRDPVASSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCTPVQLVALIRHGTRYPTVKQIRKLRQLHGLLQARGSRDGGASSTGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQGLWQHYHPGLPPPDVADMEFGPPTVNDKLMRFFDHCEKFLTEVEKNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNADLIQVAFFTCSFDLAIKGVKSPWCDVFDIDDAKVLEYLNDLKQYWKRGYGYTINSRSSCTLFQDIFQHLDKAVEQKQRSQPISSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNYKKQMHRKFRSGLIVPYASNLIFVLYHCENAKTPKEQFRVQMLLNEKVLPLAYSQETVSFYEDLKNHYKDILQSCQTSEECELARANSTSDEL
multiple inositol polyphosphate phosphatase 1 isoform 2 precursor
Refseq ID NP_001171588
Protein GI 296010986
UniProt ID Q9UNW1
mRNA ID NM_001178117
Length 312
RefSeq Status VALIDATED
MLRAPGCLLRTSVAPAAALAAALLSSLARCSLLEPRDPVASSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCTPVQLVALIRHGTRYPTVKQIRKLRQLHGLLQARGSRDGGASSTGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQGLWQHYHPGLPPPDVADMEFGPPTVNDKLMRFFDHCEKFLTEVEKNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNAGLSQFLLQSSSSLVMQRLFFHCFLSWATSKTRNP
multiple inositol polyphosphate phosphatase 1 isoform 3
Refseq ID NP_001171589
Protein GI 296010986
UniProt ID Q9UNW1
mRNA ID NM_001178118
Length 312
RefSeq Status VALIDATED
MLRAPGCLLRTSVAPAAALAAALLSSLARCSLLEPRDPVASSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCTPVQLVALIRHGTRYPTVKQIRKLRQLHGLLQARGSRDGGASSTGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQGLWQHYHPGLPPPDVADMEFGPPTVNDKLMRFFDHCEKFLTEVEKNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNAGLSQFLLQSSSSLVMQRLFFHCFLSWATSKTRNP

Gene Information

Entrez Gene ID
9562
Gene Name
multiple inositol-polyphosphate phosphatase 1
Gene Symbol
MINPP1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 TAS:ProtInc C endoplasmic reticulum
GO:0005788 TAS:Reactome C endoplasmic reticulum lumen
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0003993 IEA:InterPro F acid phosphatase activity
GO:0034417 IDA:BHF-UCL F bisphosphoglycerate 3-phosphatase activity
GO:0052826 IEA:UniProtKB-EC F inositol hexakisphosphate 2-phosphatase activity
GO:0008969 TAS:ProtInc F phosphohistidine phosphatase activity
GO:0030282 NAS:UniProtKB P bone mineralization
GO:0016311 IDA:GOC P dephosphorylation
GO:0043647 TAS:Reactome P inositol phosphate metabolic process
GO:0001503 NAS:UniProtKB P ossification
GO:0006797 TAS:ProtInc P polyphosphate metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00562 Inositol phosphate metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis
PWY-6366 D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis
PWY-6405 Rapoport-Luebering glycolytic shunt

Domain Information

InterPro Annotations

Accession Description
IPR016274 Histidine acid phosphatase, eukaryotic
IPR029033 Histidine phosphatase superfamily
IPR000560 Histidine phosphatase superfamily, clade-2

UniProt Annotations

Entry Information

Gene Name
multiple inositol-polyphosphate phosphatase 1
Protein Entry
MINP1_HUMAN
UniProt ID
Q9UNW1
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9UNW1-1; Sequence=Displayed; Name=2; IsoId=Q9UNW1-2; Sequence=VSP_014552, VSP_014555; Note=No experimental confirmation available.; Name=3; IsoId=Q9UNW1-3; Sequence=VSP_014553, VSP_014554; Note=No experimental confirmation available.; Name=4; IsoId=Q9UNW1-4; Sequence=VSP_044569; Note=No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=0.61 mM for 2,3-bisphosphoglycerate ; Vmax=15.8 nmol/min/mg enzyme with 2,3-bisphospho-D-glycerate as substrate ;
Catalytic Activity 2,3-bisphospho-D-glycerate + H(2)O = 2- phospho-D-glycerate + phosphate.
Catalytic Activity Myo-inositol hexakisphosphate + H(2)O = myo- inositol pentakisphosphate (mixed isomers) + phosphate.
Disease Note=Defects in MINPP1 may be involved in follicular thyroid tumors development.
Function Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification).
Sequence Caution Sequence=BAD93056.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the histidine acid phosphatase family. MINPP1 subfamily.
Subcellular Location Endoplasmic reticulum lumen .
Tissue Specificity Widely expressed with highest levels in kidney, liver and placenta.

Identical and Related Proteins

Unique RefSeq proteins for LMP000594 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19923761 RefSeq NP_004888 487 multiple inositol polyphosphate phosphatase 1 isoform 1 precursor
296010986 RefSeq NP_001171588 312 multiple inositol polyphosphate phosphatase 1 isoform 2 precursor
296010986 RefSeq NP_001171589 312 multiple inositol polyphosphate phosphatase 1 isoform 3

Identical Sequences to LMP000594 proteins

Reference Database Accession Length Protein Name
GI:296010986 GenBank AAD09752.1 312 multiple inositol polyphosphate phosphatase-like protein [Homo sapiens]
GI:296010986 GenBank AAD09752.1 312 multiple inositol polyphosphate phosphatase-like protein [Homo sapiens]
GI:296010986 GenBank EAW50186.1 312 multiple inositol polyphosphate histidine phosphatase, 1, isoform CRA_b [Homo sapiens]
GI:296010986 GenBank EAW50186.1 312 multiple inositol polyphosphate histidine phosphatase, 1, isoform CRA_b [Homo sapiens]
GI:19923761 GenBank ADQ31759.1 487 multiple inositol polyphosphate histidine phosphatase, 1, partial [synthetic construct]
GI:19923761 GenBank ADS26258.1 487 Sequence 204 from patent US 7777007
GI:19923761 GenBank ADS58639.1 487 Sequence 204 from patent US 7807385
GI:19923761 GenBank AFL59824.1 487 Sequence 528 from patent US 8106156
GI:19923761 GenBank AHD75226.1 487 Sequence 16505 from patent US 8586006
GI:19923761 GenBank AIC50390.1 487 MINPP1, partial [synthetic construct]

Related Sequences to LMP000594 proteins

Reference Database Accession Length Protein Name
GI:19923761 DBBJ BAG35779.1 487 unnamed protein product [Homo sapiens]
GI:19923761 EMBL CAB43673.1 487 hypothetical protein [Homo sapiens]
GI:19923761 GenBank AAD02437.1 487 multiple inositol polyphosphate phosphatase [Homo sapiens]
GI:19923761 GenBank JAA35298.1 487 multiple inositol-polyphosphate phosphatase 1 [Pan troglodytes]
GI:296010986 RefSeq XP_003255214.1 312 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform 2 [Nomascus leucogenys]
GI:296010986 RefSeq XP_003255214.1 312 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform 2 [Nomascus leucogenys]
GI:19923761 RefSeq XP_003810543.1 487 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform X1 [Pan paniscus]
GI:19923761 RefSeq XP_004049779.1 487 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform 1 [Gorilla gorilla gorilla]
GI:296010986 RefSeq XP_004049780.1 312 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform 2 [Gorilla gorilla gorilla]
GI:296010986 RefSeq XP_004049780.1 312 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform 2 [Gorilla gorilla gorilla]
GI:296010986 RefSeq XP_007961653.1 337 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform X4 [Chlorocebus sabaeus]
GI:296010986 RefSeq XP_007961653.1 337 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform X4 [Chlorocebus sabaeus]
GI:296010986 RefSeq XP_008961092.1 312 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform X3 [Pan paniscus]
GI:296010986 RefSeq XP_008961092.1 312 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform X3 [Pan paniscus]
GI:296010986 RefSeq XP_009243871.1 312 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform X1 [Pongo abelii]
GI:296010986 RefSeq XP_009243871.1 312 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform X1 [Pongo abelii]
GI:296010986 RefSeq XP_009457182.1 312 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform X3 [Pan troglodytes]
GI:296010986 RefSeq XP_009457182.1 312 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform X3 [Pan troglodytes]